Tag: 101.1701

Effect of Temperature and pH on the Generation of Flavor Volatiles in Extrusion Cooking of Wheat Flour was written by Bredie, Wender L. P.;Mottram, Donald S.;Guy, Robin C. E.. And the article was included in Journal of Agricultural and Food Chemistry in 2002.Quality Control of 2-Methyl-4,5-dihydrothiazole This article mentions the following:

Extrusion temperature (120, 135, and 150掳) and quantity of added sodium hydroxide (0, 3, and 6 g/kg feedstock) were used as variables to study flavor generation in extrusion cooking of wheat flour. In total, 127 volatile components were identified in the extrudates, of which 51 contained sulfur. The levels of pyrroles, thiophenes, thiophenones, thiapyrans, and thiazolines increased at higher extrusion temperatures, whereas furans and aldehydes decreased. The addition of sodium hydroxide also affected the formation of volatile compounds However, thiophenes, thiophenones, polythiacycloalkanes, thiazoles, thiazolines, pyrroles, and some pyrazines tended to increase with the more alk. extrusion conditions. Some compounds from lipid-Maillard interactions were identified in the extrudates. Anal. of the volatile components by gas chromatog.-olfactometry showed sulfur- and nitrogen-sulfur-containing heterocycles as possible contributors to the sulfury and rubbery odors observed in extrudates produced at the higher temperature and more alk. conditions. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Quality Control of 2-Methyl-4,5-dihydrothiazole).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Quality Control of 2-Methyl-4,5-dihydrothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nitrogen bridgehead compounds. Part 67. Preparation of novel polycyclic quaternary salts was written by Bitter, Istvan;Pete, Bela;Agai, Bela;Toke, Laszlo;Toth, Gabor;Hermecz, Istvan;Simon, Kalman;Meszaros, Zoltan;Parkanyi, Laszlo. And the article was included in Heterocycles in 1987.Computed Properties of C4H7NS This article mentions the following:

The cycloaddition reaction of (aminochloromethylene)pyridopyrimidines I (R¹ = CO₂Et, cyano) with 3,4-dihydroisoquinolines gave ioquinodiazaazoniaphenalene salts II (R² = H, Me; R³ = H, OMe; X = Cl, ClO₄). Similarly fused compounds were obtained from 2-thiazoline and 2-oxazoline derivatives, benzothiazole, and a benzoxazole derivative The crystal and mol. structure of II (R¹ = cyano, R² = R³ = H, X = Cl) were obtained. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Computed Properties of C4H7NS).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C4H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ring transformations of heterocyclic compounds. XVII. 2-(2,4,6-triarylphenyl) substituted dihydro-1H-imidazolium, dihydrothiazolium and thiazolium salts from 2-methyl derivatives by pyrylium and thiopyrylium ring transformations was written by Zimmermann, Thomas. And the article was included in Journal of Heterocyclic Chemistry in 1999.Category: thiazole This article mentions the following:

Some new 2-(2,4,6-triarylphenyl)-4,5-dihydro-1H-imidazolium perchlorates, -4,5-dihydrothiazolium perchlorates and -thiazolium perchlorates were obtained from their 2-Me analogs by a 2,6-[C₅+C] ring transformation of 2,4,6-triarylpyrylium and -thiopyrylium salts in ethanol in the presence of an appropriate base. Spectroscopic data of the transformation products and structural influences on their formation via anhydrobases of the triarylpyrylium and -thiopyrylium salts are discussed. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Category: thiazole).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The effect of heat on beef aroma: comparisons of chemical composition and sensory properties was written by MacLeod, Glesni;Ames, Jennifer M.. And the article was included in Flavour and Fragrance Journal in 1986.Safety of 2-Methyl-4,5-dihydrothiazole This article mentions the following:

Aroma volatiles of fresh cooked ground beef subjected to varying degrees of heating were adsorbed on to the adsorbent Tenax TA, and the desorbed aromas analyzed sensorially and chem. Several of the components identified by combined capillary gas chromatog.-mass spectrometry have not been reported previously from heated beef. Data is presented to support the generalization that the higher the degree of heating, the greater the concentrations of aliphatic aldehydes (especially Strecker aldehydes), benzenoids, aliphatic polysulfides, heterocyclic compounds and lipid-derived volatiles, whereas smaller contributions to the isolates arise from aliphatic ketones and alcs. (of non-lipid origin) and aliphatic mono-sulfur components. By sensory anal., eight of odor qualities were frequently used during gas chromatog. odor port assessment, namely buttery, caramel, burnt, green, fragrant, oily/fatty, nutty and meaty. Components associated with the former seven qualities are aroma modifiers whereas compounds contributing meaty quality are character impact compounds, e.g. 2-methyl-3-(methylthio)furan and 3-methylcyclopentanone. Addnl., several unsaturated alicyclic ketones were present which resemble the cyclohexenones previously known to be significant in meat aroma. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Safety of 2-Methyl-4,5-dihydrothiazole).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Safety of 2-Methyl-4,5-dihydrothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors was written by Matsuo, Tomohiko;Isosaka, Tomoko;Tang, Lijun;Soga, Tomoyoshi;Kobayakawa, Reiko;Kobayakawa, Ko. And the article was included in Communications Biology in 2021.Computed Properties of C4H7NS This article mentions the following:

Innate fear intimately connects to the life preservation in crises, although this relationships is not fully understood. Here, we report that presentation of a supernormal innate fear inducer 2-methyl-2-thiazoline (2MT), but not learned fear stimuli, induced robust systemic hypothermia/hypometabolism and suppressed aerobic metabolism via phosphorylation of pyruvate dehydrogenase, thereby enabling long-term survival in a lethal hypoxic environment. These responses exerted potent therapeutic effects in cutaneous and cerebral ischemia/reperfusion injury models. In contrast to hibernation, 2MT stimulation accelerated glucose uptake in the brain and suppressed oxygen saturation in the blood. Whole-brain mapping and chemogenetic activation revealed that the sensory representation of 2MT orchestrates physiol. responses via brain stem Sp5/NST to midbrain PBN pathway. 2MT, as a supernormal stimulus of innate fear, induced exaggerated, latent life-protective effects in mice. If this system is preserved in humans, it may be utilized to give rise to a new field: “sensory medicine”. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Computed Properties of C4H7NS).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Computed Properties of C4H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Novel synthesis of 2-thiazolines was written by Fernandez, Xavier;Fellous, Roland;Dunach, Elisabet. And the article was included in Tetrahedron Letters in 2000.Synthetic Route of C4H7NS This article mentions the following:

The synthesis of a series of 2-thiazolines was carried out under mild conditions from the corresponding thiazolidines, by a Ru-catalyzed/TBHP oxidation reaction conditions. The reaction was chemoselective towards the amine-imine oxidation and was also regioselective, affording the unsaturation at the 2-position of the heterocycle, even with thiazolidine substrates bearing ester groups at the 4-position. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Synthetic Route of C4H7NS).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Synthetic Route of C4H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Effect of Temperature and pH on the Generation of Flavor Volatiles in Extrusion Cooking of Wheat Flour was written by Bredie, Wender L. P.;Mottram, Donald S.;Guy, Robin C. E.. And the article was included in Journal of Agricultural and Food Chemistry in 2002.Quality Control of 2-Methyl-4,5-dihydrothiazole This article mentions the following:

Extrusion temperature (120, 135, and 150°) and quantity of added sodium hydroxide (0, 3, and 6 g/kg feedstock) were used as variables to study flavor generation in extrusion cooking of wheat flour. In total, 127 volatile components were identified in the extrudates, of which 51 contained sulfur. The levels of pyrroles, thiophenes, thiophenones, thiapyrans, and thiazolines increased at higher extrusion temperatures, whereas furans and aldehydes decreased. The addition of sodium hydroxide also affected the formation of volatile compounds However, thiophenes, thiophenones, polythiacycloalkanes, thiazoles, thiazolines, pyrroles, and some pyrazines tended to increase with the more alk. extrusion conditions. Some compounds from lipid-Maillard interactions were identified in the extrudates. Anal. of the volatile components by gas chromatog.-olfactometry showed sulfur- and nitrogen-sulfur-containing heterocycles as possible contributors to the sulfury and rubbery odors observed in extrudates produced at the higher temperature and more alk. conditions. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Quality Control of 2-Methyl-4,5-dihydrothiazole).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Quality Control of 2-Methyl-4,5-dihydrothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nitrogen bridgehead compounds. Part 67. Preparation of novel polycyclic quaternary salts was written by Bitter, Istvan;Pete, Bela;Agai, Bela;Toke, Laszlo;Toth, Gabor;Hermecz, Istvan;Simon, Kalman;Meszaros, Zoltan;Parkanyi, Laszlo. And the article was included in Heterocycles in 1987.Computed Properties of C4H7NS This article mentions the following:

The cycloaddition reaction of (aminochloromethylene)pyridopyrimidines I (R¹ = CO₂Et, cyano) with 3,4-dihydroisoquinolines gave ioquinodiazaazoniaphenalene salts II (R² = H, Me; R³ = H, OMe; X = Cl, ClO₄). Similarly fused compounds were obtained from 2-thiazoline and 2-oxazoline derivatives, benzothiazole, and a benzoxazole derivative The crystal and mol. structure of II (R¹ = cyano, R² = R³ = H, X = Cl) were obtained. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Computed Properties of C4H7NS).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C4H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica