13743-09-4, 2-Methyl-5-phenylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: 2-methyl-5-phenylthiazole-4-carboxylic acid (1 .3 eq) and HOBT (2.3 eq) were suspended in dry DCM under nitrogen atmosphere. Then Si-DCC (silica supported carbodiimide from Silicycle, 2.5-3 eq) was added and the mixture was shaken for 10 minutes. After that, a solution of (D27-46) (1 eq) in dry dichloromethane was added and the mixture was shaken at room temperature for 18 hours. The supported reagent was then filtered andwashed with MeOH and DCM. The liquid phase was evaporated; the obtained residue was taken up in DCM and the resulting solution washed with an aqueous saturated solution of NaHCO3.The organic layer was isolated and evaporated. The residue was then purified by flash chromatography on silica gel.
13743-09-4 2-Methyl-5-phenylthiazole-4-carboxylic acid 943535, athiazole compound, is more and more widely used in various.
Reference£º
Patent; ROTTAPHARM SPA; STASI, Luigi Piero; ROVATI, Lucio Claudio; ARTUSI, Roberto; COLACE, Fabrizio; MANDELLI, Stefano; PERUGINI, Lorenzo; WO2013/92893; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica