With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13750-63-5,(4-Methylthiazol-2-yl)methanol,as a common compound, the synthetic route is as follows.
Preparation 37; 2-Bromomethyl-5-chloro-thiopheneCool (5-chloro-thiophen-2-yl)-methanol (Preparation 30) (330 mg, 2.22 mmol) to 0 0C and add acetyl bromide (709 mg, 430 muL, 5.76 mmol). Allow to warm to room temperature over 18 h, dilute with EtOAc (10 mL), and cautiously add saturated aqueous NaHCO3 (3 mL). When the carbon dioxide evolution stops, load the mixture onto a Varian Chem Elut CE1005 solid phase extraction cartridge (Varian part number 12198006). Elute with EtOAc, collect, and concentrate about 50 mL to obtain the crude product. Purify on silica gel (12 g) using 0-15% EtOAc/hexanes to afford 250 mg (53%) of the title compound as a yellow oil. MS (EI): 210,212; 1H NMR (CDCl3): delta 6.92 (d, IH, /=3.5 Hz), 6.78 (d, IH, /=4.0 Hz), 4.66 (s, 2H).
13750-63-5 (4-Methylthiazol-2-yl)methanol 17750909, athiazole compound, is more and more widely used in various.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/2181; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica