Tag: 143.1637

Unexpected Intermolecular Pd-Catalyzed Cross-Coupling Reaction Employing Heteroaromatic Carboxylic Acids as Coupling Partners was written by Forgione, Pat;Brochu, Marie-Christine;St-Onge, Miguel;Thesen, Kris H.;Bailey, Murray D.;Bilodeau, Francois. And the article was included in Journal of the American Chemical Society in 2006.Name: 4-Methylthiazole-5-carboxylic acid This article mentions the following:

A palladium catalyzed decarboxylative cross-coupling reaction of five-membered heteroaromatic carboxylic acids with aryl bromides for preparing aryl-substituted heteroaromatics has been disclosed. The coupling on the carbon connecting carboxyl group is an attractive complement to the existing C-H functionalization method. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0Name: 4-Methylthiazole-5-carboxylic acid).

4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: 4-Methylthiazole-5-carboxylic acid

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thiomethylation and thiohydroxylation – a new pathway of metabolism of heterocyclic compounds was written by Pal, R.;Spiteller, G.. And the article was included in Xenobiotica in 1982.Reference of 20485-41-0 This article mentions the following:

Gas-liquid chromatog.-mass spectral anal. of thin-layer chromatog. fractions of urine samples from patients treated with clomethiazole (I) [533-45-9] revealed 2 minor metabolites formed by thiomethylation and thiohydroxylation, namely 2-methylthioclomethiazole聽聽[87764-52-1] and 5-acetyl-4-methyl-2-methylmercaptothiazole聽聽[73548-99-9], resp. The structures of 6 other minor metabolites resulting from side-chain degradation were also elucidated. The occurrence of metabolites with substituents at position 2 of the heterocyclic nucleus was assumed to be initiated by oxidative attack of the N, followed by nucleophilic substitution at position 2. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0Reference of 20485-41-0).

4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Reference of 20485-41-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides was written by Li, Xuefei;Feng, Zhang;Jiang, Zhong-Xing;Zhang, Xingang. And the article was included in Organic Letters in 2015.HPLC of Formula: 20485-41-0 This article mentions the following:

A mild and efficient nickel-catalyzed reductive cross-coupling between fluorinated secondary alkyl bromides and (hetero)aryl iodides is described. The use of FeBr₂ as an additive successfully overcomes the hydrodebromination and β-fluorine elimination of fluorinated substrates and allows the efficient synthesis of a wide range of trifluoromethyl and difluoroalkyl containing aliphatic compounds with a fluoroalkyl substituted tertiary carbon center. The notable features of this protocol are the synthetic and operational simplicity without preparation of moisture sensitive organometallic reagents and excellent functional group compatibility, even toward active proton containing substrates. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0HPLC of Formula: 20485-41-0).

4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.HPLC of Formula: 20485-41-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Crystalline vitamin B₁. XIII. Ultraviolet absorption of some derivatives of the basic cleavage product and their synthetic analogs was written by Ruehle, A. E.. And the article was included in Journal of the American Chemical Society in 1935.Recommanded Product: 20485-41-0 This article mentions the following:

The ultraviolet absorption of the basic cleavage product of vitamin B₁ is not only similar to that of the thiazoles but its derivatives exhibit absorption similar to that of corresponding thiazole derivatives Curves are given for the basic product, 4-methyl-, 2,4-dimethyl- and 2-hydroxy-4-methylthiazole HCl salts, 4-methylthiazole-EtI, 4-methylthiazole-5- carboxylic acid and the Cl derivative of the basic product. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0Recommanded Product: 20485-41-0).

4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Recommanded Product: 20485-41-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Unexpected Intermolecular Pd-Catalyzed Cross-Coupling Reaction Employing Heteroaromatic Carboxylic Acids as Coupling Partners was written by Forgione, Pat;Brochu, Marie-Christine;St-Onge, Miguel;Thesen, Kris H.;Bailey, Murray D.;Bilodeau, Francois. And the article was included in Journal of the American Chemical Society in 2006.Name: 4-Methylthiazole-5-carboxylic acid This article mentions the following:

A palladium catalyzed decarboxylative cross-coupling reaction of five-membered heteroaromatic carboxylic acids with aryl bromides for preparing aryl-substituted heteroaromatics has been disclosed. The coupling on the carbon connecting carboxyl group is an attractive complement to the existing C-H functionalization method. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0Name: 4-Methylthiazole-5-carboxylic acid).

4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: 4-Methylthiazole-5-carboxylic acid

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thiomethylation and thiohydroxylation – a new pathway of metabolism of heterocyclic compounds was written by Pal, R.;Spiteller, G.. And the article was included in Xenobiotica in 1982.Reference of 20485-41-0 This article mentions the following:

Gas-liquid chromatog.-mass spectral anal. of thin-layer chromatog. fractions of urine samples from patients treated with clomethiazole (I) [533-45-9] revealed 2 minor metabolites formed by thiomethylation and thiohydroxylation, namely 2-methylthioclomethiazole  [87764-52-1] and 5-acetyl-4-methyl-2-methylmercaptothiazole  [73548-99-9], resp. The structures of 6 other minor metabolites resulting from side-chain degradation were also elucidated. The occurrence of metabolites with substituents at position 2 of the heterocyclic nucleus was assumed to be initiated by oxidative attack of the N, followed by nucleophilic substitution at position 2. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0Reference of 20485-41-0).

4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Reference of 20485-41-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica