With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182344-57-6,4-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.
EXAMPLE 183 (+)-(4aR)-(10bR)-4-methyl-8-(4-bromo-2-benzothiazolylthio)-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one A 15 mL round bottom flask was charged with (+)-(4aR)-(10bR)-4-methyl-8-mercapto-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one (100 mg, 0.38 mmol), potassium carbonate (158 mg, 1.14 mmol), 2-chloro-4-bromobenzothiazole (114 mg, 0.46 mmol) and 1 mL of anhydrous dimethylformamide, fitted with a reflux condenser, and the stirred mixture was heated at 60, under nitrogen, for 18 h. The mixture was cooled, diluted with ethyl acetate (75 mL) and washed with brine (2*25 mL). The combined organic extracts were dried over sodium sulfate, concentrated, and purified by silica gel chromatography (ethyl acetate eluent) to give 142 mg (79%) of the title compound as an off white solid. mp 206-210. FDMS: m/e=474. alpha[D]589 =+56.25 (c=0.59, chloroform).
182344-57-6 4-Bromo-2-chlorobenzo[d]thiazole 2049865, athiazole compound, is more and more widely used in various.
Reference£º
Patent; Eli Lilly and Company; US5550134; (1996); A;; ; Patent; ELi Lilly and Company; US5629007; (1997); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica