Tag: 200.2596

Aminobenzothiazoles. III. Tautomerism and unsaturation of the aminothiazole system was written by Hunter, R. F.. And the article was included in Journal of the Chemical Society in 1926.Application of 40172-65-4 This article mentions the following:

1-Aminobenzothiazole (I) and MeI at 100掳 for 5 hrs. give 1-imino-2-methyl-1,2-dihydrobenzothiazole (II), m. 123掳, whose constitution was established by its synthesis from the dibromide, orange-red, sinters and softens at 125掳 (prepared from PhNMeC(:S)NH₂ and Br in CHCl₃). There is also probably formed some 1-methylaminobenzothiazole (III), m. 138掳, which was prepared from the tetrabromide (IV), scarlet, m. 65-7掳 (decomposition) (prepared from PhNHC(:S)NHMe and Br in CHCl₃). Ethylation of I gave the 2-Et derivative corresponding to II, pale yellow, m. 85掳, likewise prepared from its tetrabromide, vermilion-orange, m. 160-1掳 (decomposition). Acetylation of I gives almost quant. the 1-Ac derivative, m. 186掳, also obtained by the reduction of its tetrabromide, orange-red, m. 137-9掳; the isomer could not be obtained pure. II in CHCl₃, treated with excess of 20% Br in CHCl₃, gives a tribromide, orange, becomes white without melting at 245掳. IV, exposed to the air for 20 hrs., loses Br and forms the orange-yellow dibromide, sinters 136掳, chars at 191掳; it loses more Br on further exposure. IV in absolute EtOH, after dilution with H₂O and concentration, gives a mixture of Br- and Br₂-substitution products, which could not be separated 1-Imino-2-acetyl-1,2-dihydrobenzothiazole (V), m. 118-20掳, results by the reduction with H₂SO₃ of the dibromide (VI), orange, m. 130-2掳 (from the labile form of PhNHC(:S)NH₂); a 2nd form, purplish red, sinters 160掳, m. 173掳 (decomposition), which is very stable in air and is more slowly reduced by SO₂, was also isolated. The HBr salt, dark chocolate prisms, turns orange 178掳 and m. 180掳 (decomposition). Hydrolysis of V gives I. 1-Benzoylaminobenzothiazole tetrabromide, orange-yellow, becomes colorless and loses Br at about 185掳; boiling in EtOH gives 5-bromo-1-benzoylaminobenzothiazole, m. 226掳. I, diazotized and treated with 尾-C₁₀H₇OH, gives benzothiazole-1-azo-尾-naphthol, deep purple-red, m. 146掳; it dyes cotton a fugitive shade of yellow; reduction gives I. 1-Aminoazobenzothiazole, cream-white, m. 135掳; HCl salt, yellow, m. 232掳 (decomposition). With NaOCl this gives a dark purple compound, m. 156-8掳. EtNO₂ in EtOH gives 蠄-aminobenzothiazole, pale yellow, m. about 127掳, isolated as the HCl salt, ruby-red or deep orange, m. 239-40掳. 蠄-Amino-3-toluthiazole HCl salt, ruby-red, sinters 145掳, changes color at 145掳; the corresponding 5-derivative, red, sinters 130掳, softens about 150掳. These facts establish the mobility of I. 5-Bromo-1-amino-benzothiazole dibromide (VII), orange-red, softens 80-2掳, from p-BrC₆H₄NHC(:S)NH₂ and Br in CHCl₃; H₂SO₃ and NH₃ convert it into the free thiazole, m. 211掳. 1-Acetylaminobenzothiazole hexabromide, orange-red, turns yellow at 130掳, loses Br at 140掳 and becomes colorless at about 160掳; in EtOH it gives 5-bromo-1-acetylaminobenzothiazole, m. 223掳. VI in EtOH gives 5-bromo-1-imino-2-acetyl-1,2-dihydrobenzothiazole, m. 199-200掳. Hydrolysis of each of these gives 5-bromo-1-aminobenzothiazole. 1-Amino-3-methylbenzothiazole, m. 136掳, results by reduction of the dibromide, orange, m. 110掳 (decomposition), which in turn is formed from o-MeC₆H₄NHC(:S)NH₂ and Br in CHCl₃; the latter is unstable and loses Br in the air; in EtOH it gives the HBr salt, turns yellow at 260掳, chars about 290掳, of bromo-1-amino-3-methylbenzothiazole, m. 212掳. 1-Amino-5-methylbenzothiazole, m. 142掳, is formed from the dibromide-HBr, orange-red, m. 134掳 (decomposition); with EtOH the latter yields a Br substitution product, m. 210掳. 1-Amino-4-methylbenzothiazole, m. 145掳, from the tetrabromide, orange-red, m. about 250掳 (decomposition) after undergoing a series of color changes. The 3,5-di-Me derivative, m. 116掳; its tetrabromide, red, does not m. 250掳 and is very unstable, losing Br and becoming colorless on exposure to the air for 0.5 hr. 2-Amino-尾-naphthothiazole, sinters 220掳, m. 235-7掳; tetrabromide, orange, does not m. 260掳; the corresponding 伪-derivative, sinters 230掳, m. 249-51掳; tetrabromide, yellow, m. 165掳 (decomposes). I dibromide in nearly boiling H₂O gives VII. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Application of 40172-65-4).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application of 40172-65-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Development of a QPatch Automated Electrophysiology Assay for Identifying KCa3.1 Inhibitors and Activators was written by Jenkins, David Paul;Yu, Weifeng;Brown, Brandon M.;Lojkner, Lars Damgaard;Wulff, Heike. And the article was included in Assay and Drug Development Technologies in 2013.Category: thiazole This article mentions the following:

The intermediate-conductance Ca²⁺-activated K⁺ channel KCa3.1 (also known as KCNN4, IK1, or the Gardos channel) plays an important role in the activation of T and B cells, mast cells, macrophages, and microglia by regulating membrane potential, cellular volume, and calcium signaling. KCa3.1 is further involved in the proliferation of dedifferentiated vascular smooth muscle cells and fibroblast and endothelium-derived hyperpolarization responses in the vascular endothelium. Accordingly, KCa3.1 inhibitors are therapeutically interesting as immunosuppressants and for the treatment of a wide range of fibroproliferative disorders, whereas KCa3.1 activators constitute a potential new class of endothelial function preserving antihypertensives. Here, we report the development of QPatch assays for both KCa3.1 inhibitors and activators. During assay optimization, the Ca²⁺ sensitivity of KCa3.1 was studied using varying intracellular Ca²⁺ concentrations A free Ca²⁺ concentration of 1 渭M was chosen to optimally test inhibitors. To identify activators, which generally act as pos. gating modulators, a lower Ca²⁺ concentration (鈭?00 nM) was used. The QPatch results were benchmarked against manual patch-clamp electrophysiol. by determining the potency of several commonly used KCa3.1 inhibitors (TRAM-34, NS6180, ChTX) and activators (EBIO, riluzole, SKA-31). Collectively, our results demonstrate that the QPatch provides a comparable but much faster approach to study compound interactions with KCa3.1 channels in a robust and reliable assay. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Category: thiazole).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Correlation between the inhibiting action of 2-aminothiazoles and their electron structure was written by Mal’tseva, V. P.;Momsenko, A. P.. And the article was included in Zashchita Metallov in 1979.Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine This article mentions the following:

Quantum chem. calculations were made for electron structure of 2-aminobenzothiazole [136-95-8] (I), 2-aminonaphtho-1,2,4,5-thiazole [40172-65-4] (II), and 2-amino-4,5,6,7-tetrahydrobenzothiazole [2933-29-1] (III). Their corrosion inhibition and polarization voltage were determined in 1N HCl and 1N H₂SO₄ for steel St2 [12742-82-4] and St 3 [39296-41-8]. Corrosion rate reductions were 85-87, 90.4-93.5, and 96-99.5% for I, II, and III, resp. The mols. showed effective charge separation on N and S. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Condensation of aromatic amines with nitrosobenzene in basic medium. II. Heteroaromatic amines was written by Pentimalli, Luciano;Milani, Giovanni. And the article was included in Annali di Chimica (Rome, Italy) in 1989.Category: thiazole This article mentions the following:

Aminobenzothiazoles, -naphthothiazoles and -1,2,4-thiadiazoles condense, in alk. medium, with nitrosobenzene as well as its 4-chloro derivative to give the corresponding azo compounds Aminothiazoles and -1,3,4-thiadiazoles did not give condensation products. 4-Nitro- and 4-dimethylaminonitrosobenzene gave the corresponding azoxybenzene as main reaction product. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Category: thiazole).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In silico study of naphtha [1, 2-d] thiazol-2-amine with adenosine A_2A receptor and its role in antagonism of haloperidol-induced motor impairments in mice was written by Luthra, Pratibha Mehta;Prakash, Amresh;Barodia, Sandeep Kumar;Kumari, Rita;Mishra, Chandra Bhushan;Kumar, J. B. Senthil. And the article was included in Neuroscience Letters in 2009.Safety of Naphtho[1,2-d]thiazol-2-amine This article mentions the following:

Loss of dopaminergic nigrostriatal neurons in the substantia nigra leads to Parkinson’s disease (PD). Adenosine A_2A receptors (A_2ARs) have been anticipated as novel therapeutic target for PD. A_2ARs potentiate locomotor behavior and are predominantly expressed in striatum. Naphtha [1, 2-d] thiazol-2-amine (NATA), a tricyclic thiazole have been studied as new anti-Parkinsonian compound AutoDock anal. and pharmacophore study of NATA with known A_2AR antagonists explicit its efficacy as a possible adenosine receptor antagonist. In vivo pharmacol. of NATA showed reduction of haloperidol (HAL)-induced motor impairments in Swiss albino male mice. Relatively elevated levels of dopamine in NATA pre-treated mice are suggestive of its possible role as neuromodulator in PD. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Safety of Naphtho[1,2-d]thiazol-2-amine).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of Naphtho[1,2-d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A pharmacologic activator of endothelial KCa channels increases systemic conductance and reduces arterial pressure in an anesthetized pig model was written by Mishra, Ramesh C.;Mitchell, Jamie R.;Gibbons-Kroeker, Carol;Wulff, Heike;Belenkie, Israel;Tyberg, John V.;Braun, Andrew P.. And the article was included in Vascular Pharmacology in 2016.Safety of Naphtho[1,2-d]thiazol-2-amine This article mentions the following:

SKA-31, an activator of endothelial KCa2.3 and KCa3.1 channels, reduces systemic blood pressure in mice and dogs, however, its effects in larger mammals are not well known. We therefore examined the hemodynamic effects of SKA-31, along with sodium nitroprusside (SNP), in anesthetized, juvenile male domestic pigs. Exptl., continuous measurements of left ventricular (LV), aortic and inferior vena cava (IVC) pressures, along with flows in the ascending aorta, carotid artery, left anterior descending coronary artery and renal artery, were performed during acute administration of SKA-31 (0.1, 0.3, 1.0, 3.0 and 5.0 mg/mL/kg) and a single dose of SNP (5.0 μg/mL/kg). SKA-31 dose-dependently reduced mean aortic pressure (mP_AO), with the highest dose decreasing mP_AO to a similar extent as SNP (- 23 ± 3 and – 28 ± 4 mm Hg, resp.). IVC pressure did not change. Systemic conductance and conductance in coronary and carotid arteries increased in response to SKA-31 and SNP, but renal artery conductance was unaffected. There was no change in either LV stroke volume (SV) or heart rate (vs. the preceding control) for any infusion. With no change in SV, drug-evoked decreases in LV stroke work (SW) were attributed to reductions in mP_AO (SW vs. mP_AO, r² = 0.82, P < 0.001). In summary, SKA-31 dose-dependently reduced mP_AO by increasing systemic and arterial conductances. Primary reductions in mP_AO by SKA-31 largely account for associated decreases in SW, implying that SKA-31 does not directly impair cardiac contractility. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Safety of Naphtho[1,2-d]thiazol-2-amine).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Safety of Naphtho[1,2-d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Aminobenzothiazoles. III. Tautomerism and unsaturation of the aminothiazole system was written by Hunter, R. F.. And the article was included in Journal of the Chemical Society in 1926.Application of 40172-65-4 This article mentions the following:

1-Aminobenzothiazole (I) and MeI at 100° for 5 hrs. give 1-imino-2-methyl-1,2-dihydrobenzothiazole (II), m. 123°, whose constitution was established by its synthesis from the dibromide, orange-red, sinters and softens at 125° (prepared from PhNMeC(:S)NH₂ and Br in CHCl₃). There is also probably formed some 1-methylaminobenzothiazole (III), m. 138°, which was prepared from the tetrabromide (IV), scarlet, m. 65-7° (decomposition) (prepared from PhNHC(:S)NHMe and Br in CHCl₃). Ethylation of I gave the 2-Et derivative corresponding to II, pale yellow, m. 85°, likewise prepared from its tetrabromide, vermilion-orange, m. 160-1° (decomposition). Acetylation of I gives almost quant. the 1-Ac derivative, m. 186°, also obtained by the reduction of its tetrabromide, orange-red, m. 137-9°; the isomer could not be obtained pure. II in CHCl₃, treated with excess of 20% Br in CHCl₃, gives a tribromide, orange, becomes white without melting at 245°. IV, exposed to the air for 20 hrs., loses Br and forms the orange-yellow dibromide, sinters 136°, chars at 191°; it loses more Br on further exposure. IV in absolute EtOH, after dilution with H₂O and concentration, gives a mixture of Br- and Br₂-substitution products, which could not be separated 1-Imino-2-acetyl-1,2-dihydrobenzothiazole (V), m. 118-20°, results by the reduction with H₂SO₃ of the dibromide (VI), orange, m. 130-2° (from the labile form of PhNHC(:S)NH₂); a 2nd form, purplish red, sinters 160°, m. 173° (decomposition), which is very stable in air and is more slowly reduced by SO₂, was also isolated. The HBr salt, dark chocolate prisms, turns orange 178° and m. 180° (decomposition). Hydrolysis of V gives I. 1-Benzoylaminobenzothiazole tetrabromide, orange-yellow, becomes colorless and loses Br at about 185°; boiling in EtOH gives 5-bromo-1-benzoylaminobenzothiazole, m. 226°. I, diazotized and treated with β-C₁₀H₇OH, gives benzothiazole-1-azo-β-naphthol, deep purple-red, m. 146°; it dyes cotton a fugitive shade of yellow; reduction gives I. 1-Aminoazobenzothiazole, cream-white, m. 135°; HCl salt, yellow, m. 232° (decomposition). With NaOCl this gives a dark purple compound, m. 156-8°. EtNO₂ in EtOH gives ψ-aminobenzothiazole, pale yellow, m. about 127°, isolated as the HCl salt, ruby-red or deep orange, m. 239-40°. ψ-Amino-3-toluthiazole HCl salt, ruby-red, sinters 145°, changes color at 145°; the corresponding 5-derivative, red, sinters 130°, softens about 150°. These facts establish the mobility of I. 5-Bromo-1-amino-benzothiazole dibromide (VII), orange-red, softens 80-2°, from p-BrC₆H₄NHC(:S)NH₂ and Br in CHCl₃; H₂SO₃ and NH₃ convert it into the free thiazole, m. 211°. 1-Acetylaminobenzothiazole hexabromide, orange-red, turns yellow at 130°, loses Br at 140° and becomes colorless at about 160°; in EtOH it gives 5-bromo-1-acetylaminobenzothiazole, m. 223°. VI in EtOH gives 5-bromo-1-imino-2-acetyl-1,2-dihydrobenzothiazole, m. 199-200°. Hydrolysis of each of these gives 5-bromo-1-aminobenzothiazole. 1-Amino-3-methylbenzothiazole, m. 136°, results by reduction of the dibromide, orange, m. 110° (decomposition), which in turn is formed from o-MeC₆H₄NHC(:S)NH₂ and Br in CHCl₃; the latter is unstable and loses Br in the air; in EtOH it gives the HBr salt, turns yellow at 260°, chars about 290°, of bromo-1-amino-3-methylbenzothiazole, m. 212°. 1-Amino-5-methylbenzothiazole, m. 142°, is formed from the dibromide-HBr, orange-red, m. 134° (decomposition); with EtOH the latter yields a Br substitution product, m. 210°. 1-Amino-4-methylbenzothiazole, m. 145°, from the tetrabromide, orange-red, m. about 250° (decomposition) after undergoing a series of color changes. The 3,5-di-Me derivative, m. 116°; its tetrabromide, red, does not m. 250° and is very unstable, losing Br and becoming colorless on exposure to the air for 0.5 hr. 2-Amino-β-naphthothiazole, sinters 220°, m. 235-7°; tetrabromide, orange, does not m. 260°; the corresponding α-derivative, sinters 230°, m. 249-51°; tetrabromide, yellow, m. 165° (decomposes). I dibromide in nearly boiling H₂O gives VII. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Application of 40172-65-4).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application of 40172-65-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Development of a QPatch Automated Electrophysiology Assay for Identifying KCa3.1 Inhibitors and Activators was written by Jenkins, David Paul;Yu, Weifeng;Brown, Brandon M.;Lojkner, Lars Damgaard;Wulff, Heike. And the article was included in Assay and Drug Development Technologies in 2013.Category: thiazole This article mentions the following:

The intermediate-conductance Ca²⁺-activated K⁺ channel KCa3.1 (also known as KCNN4, IK1, or the Gardos channel) plays an important role in the activation of T and B cells, mast cells, macrophages, and microglia by regulating membrane potential, cellular volume, and calcium signaling. KCa3.1 is further involved in the proliferation of dedifferentiated vascular smooth muscle cells and fibroblast and endothelium-derived hyperpolarization responses in the vascular endothelium. Accordingly, KCa3.1 inhibitors are therapeutically interesting as immunosuppressants and for the treatment of a wide range of fibroproliferative disorders, whereas KCa3.1 activators constitute a potential new class of endothelial function preserving antihypertensives. Here, we report the development of QPatch assays for both KCa3.1 inhibitors and activators. During assay optimization, the Ca²⁺ sensitivity of KCa3.1 was studied using varying intracellular Ca²⁺ concentrations A free Ca²⁺ concentration of 1 μM was chosen to optimally test inhibitors. To identify activators, which generally act as pos. gating modulators, a lower Ca²⁺ concentration (∼200 nM) was used. The QPatch results were benchmarked against manual patch-clamp electrophysiol. by determining the potency of several commonly used KCa3.1 inhibitors (TRAM-34, NS6180, ChTX) and activators (EBIO, riluzole, SKA-31). Collectively, our results demonstrate that the QPatch provides a comparable but much faster approach to study compound interactions with KCa3.1 channels in a robust and reliable assay. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Category: thiazole).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Correlation between the inhibiting action of 2-aminothiazoles and their electron structure was written by Mal’tseva, V. P.;Momsenko, A. P.. And the article was included in Zashchita Metallov in 1979.Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine This article mentions the following:

Quantum chem. calculations were made for electron structure of 2-aminobenzothiazole [136-95-8] (I), 2-aminonaphtho-1,2,4,5-thiazole [40172-65-4] (II), and 2-amino-4,5,6,7-tetrahydrobenzothiazole [2933-29-1] (III). Their corrosion inhibition and polarization voltage were determined in 1N HCl and 1N H₂SO₄ for steel St2 [12742-82-4] and St 3 [39296-41-8]. Corrosion rate reductions were 85-87, 90.4-93.5, and 96-99.5% for I, II, and III, resp. The mols. showed effective charge separation on N and S. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Condensation of aromatic amines with nitrosobenzene in basic medium. II. Heteroaromatic amines was written by Pentimalli, Luciano;Milani, Giovanni. And the article was included in Annali di Chimica (Rome, Italy) in 1989.Category: thiazole This article mentions the following:

Aminobenzothiazoles, -naphthothiazoles and -1,2,4-thiadiazoles condense, in alk. medium, with nitrosobenzene as well as its 4-chloro derivative to give the corresponding azo compounds Aminothiazoles and -1,3,4-thiadiazoles did not give condensation products. 4-Nitro- and 4-dimethylaminonitrosobenzene gave the corresponding azoxybenzene as main reaction product. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Category: thiazole).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica