In silico study of naphtha [1, 2-d] thiazol-2-amine with adenosine A2A receptor and its role in antagonism of haloperidol-induced motor impairments in mice was written by Luthra, Pratibha Mehta;Prakash, Amresh;Barodia, Sandeep Kumar;Kumari, Rita;Mishra, Chandra Bhushan;Kumar, J. B. Senthil. And the article was included in Neuroscience Letters in 2009.Safety of Naphtho[1,2-d]thiazol-2-amine This article mentions the following:
Loss of dopaminergic nigrostriatal neurons in the substantia nigra leads to Parkinson’s disease (PD). Adenosine A2A receptors (A2ARs) have been anticipated as novel therapeutic target for PD. A2ARs potentiate locomotor behavior and are predominantly expressed in striatum. Naphtha [1, 2-d] thiazol-2-amine (NATA), a tricyclic thiazole have been studied as new anti-Parkinsonian compound AutoDock anal. and pharmacophore study of NATA with known A2AR antagonists explicit its efficacy as a possible adenosine receptor antagonist. In vivo pharmacol. of NATA showed reduction of haloperidol (HAL)-induced motor impairments in Swiss albino male mice. Relatively elevated levels of dopamine in NATA pre-treated mice are suggestive of its possible role as neuromodulator in PD. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Safety of Naphtho[1,2-d]thiazol-2-amine).
Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of Naphtho[1,2-d]thiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica