Tag: 200-300

Infrared and the near-ultraviolet absorption spectra of guanidine and benzothiazole derivatives was written by Suresh, K. S.;Ramachandran, J.;Rao, C. N. R.. And the article was included in Journal of Scientific & Industrial Research in 1961.Computed Properties of C13H10N2S This article mentions the following:

Infrared and ultraviolet absorption spectra of guanidine and benzothiazole derivatives showed characteristic bands. Mono-, di-, and triphenyl guanidines had bands at 1692, 1647, and 1659 cm.^-1, possibly due to variations of band order with conjugation, while in the ultraviolet region they showed progressively increasing bathochromic shifts. The ultraviolet spectrum of 2-mercaptobenzothiazole (I) in acid and basic media showed a variation in the absorption maximum, possibly due to the 2,3-dihydrobenzathiazole-2-thione structure assumed by I. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Interaction of sulfur monochloride with thiocarbamide and thiocarbanilide was written by Sahasrabudhey, R. H.. And the article was included in Journal of the Indian Chemical Society in 1950.Safety of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

S₂Cl₂ (I) with thiourea in CHCl₃ or absolute EtOH gave a yellow solid from which water extracted α,α’-dithiodiformamidine (II); nitrate, m. 138° (decomposition); picrate, m. 154° (decomposition). Alk. hydrolysis of II formed S, thiourea, and NH₂CN. I (2 cc.) in 10 cc. of C₆H₆ or CHCl₃ refluxed 20 min. with 4 g. of CS(NHPh)₂ in 50 cc. of solvent, after evaporation of the solvent and extraction with EtOH, gave 3.6 g. 2-anilinobenzothiazole, m. 159°; Ac derivative, m. 162-3°. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Safety of N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Safety of N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Benzothiazole-based compounds as potent endothelial lipase inhibitors was written by Meng, Wei;Adam, Leonard P.;Behnia, Kamelia;Zhao, Lei;Yang, Richard;Kopcho, Lisa M.;Locke, Gregory A.;Taylor, David S.;Yin, Xiaohong;Wexler, Ruth R.;Finlay, Heather. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.SDS of cas: 80945-86-4 This article mentions the following:

A series of benzothiazoles with a cyano group was synthesized and evaluated as endothelial lipase (EL) inhibitors for the potential treatment of cardiovascular diseases. Efforts to reduce mol. weight and polarity in the series led to improved physicochem. properties of these compounds, as well as selectivity for EL over hepatic lipase (HL). As a benchmark compound, I demonstrated potent EL activity, an acceptable absorption, distribution, metabolism and elimination (ADME) profile and pharmacokinetic (PK) exposure which allowed further evaluation in preclin. animal efficacy studies. In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4SDS of cas: 80945-86-4).

6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.SDS of cas: 80945-86-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Design, synthesis, and biological evaluation of 2-substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors was written by Liu, Jingbao;Deng, Xinxian;Jin, Yan;Xu, Buzhe;Liu, Wenlu;Jiang, Faqin;Fu, Lei. And the article was included in Pharmazie in 2015.COA of Formula: C15H12N2S This article mentions the following:

Fifteen 2-substituted ethenesulfonic acid ester derivatives were designed, synthesized, and evaluated for the inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and T-Cell protein tyrosine phosphatase (TCPTP). The structural activity relationship (SAR) of these compounds were discussed to clarify the impact of the linker and the optimized tail on the inhibitory activity of PTP1B and selectivity over TCPTP. Most of the compounds exhibited excellent inhibitory activities against PTP1B with IC₅₀ values of 1.5-8.9 μM. SAR anal. revealed that the substituents at the hydrophobic tail significantly alter the inhibitory activity against PTP1B and selectivity over TCPTP, e.g. compound Ethyl-2-(4-(3-(4-(2-chlorophenyl)thiazol-2-ylamino)propoxy)phenyl)ethenesulfonate showed excellent inhibitory activity to PTP1B with IC₅₀ = 7.8 μM, and ∼6-fold selectivity over TCPTP. Combined with our previous findings, that the linker length and the substituted hydrophobic tail had decisive influence on the PTP1B inhibitory activity and selectivity was confirmed. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7COA of Formula: C15H12N2S).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.COA of Formula: C15H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of 2-amino-4,5-diphenylthiazoles was written by Liu, Wei-wei;Huo, Yun-feng;Zhang, Qiang;Li, Qu-xiang;Wu, Jun;Fang, Qun. And the article was included in Huaxue Shiji in 2014.Electric Literature of C15H12N2S This article mentions the following:

Five 2-hydroxy-1,2-diarylenthanones were synthesized by benzoin condensation with aromatic aldehydes as raw material and the reaction conditions were investigated. The optimized conditions are: n(catalyst) = 20 mol%, n(NaOH) = 10 mol%, and V(H₂O) : V(C₂H₅OH) = 1 : 3 as reagent. The 2-amino-4,5-diarylthiazoles I(R = H, 4-Me, 4-MeO, 2-MeO, 4-Cl, 2-Cl) were synthesized from 2-hydroxy-1,2-diary lenthanones by a two-step reaction of chlorination and cyclization. The structures of were confirmed by IR, ¹HNMR and HRMS. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Electric Literature of C15H12N2S).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Electric Literature of C15H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C-H sulfurization: a new route to 2-aminobenzothiazoles was written by Yao, Guangkai;Wang, Bing-Feng;Yang, Shuai;Zhang, Zhi-Xiang;Xu, Han-Hong;Tang, Ri-Yuan. And the article was included in RSC Advances in 2019.Synthetic Route of C13H10N2S This article mentions the following:

DMSO was found to activate arylisothiocyanates for self-nucleophilic addition A subsequent intramol. C-H sulfurization catalyzed by PdBr₂ enable accessed to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C-H sulfurization of two isothiocyanates. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Synthetic Route of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Synthetic Route of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Benzothiazole. I. Nitration and bromination of 2-chlorobenzothiazole was written by Colonna, Martino. And the article was included in Pubbl. ist. chim. univ. Bologna in 1943.HPLC of Formula: 80945-86-4 This article mentions the following:

According to the hypothesis of Bonino (C.A. 34, 323.6) direct “cationoid” substitution (halogenation, nitration, etc.) of benzothiazole (I) should be directed toward the positions of the H atoms statistically pos., i. e., 4 or 6, while “anionoid” substitution (e. g., with NaNH₂, NH₂OH, etc.) should be directed toward the positions of the H atom statistically neg., i. e., 2. In order to test these predictions, 2-chlorobenzothiazole (II) was prepared (cf. Ger. pat. 516,996 (C.A. 25, 3015)) by the action of PCl₅ and POCl₃ on 2-mercaptobenzothiazole (III). II dissolved in concentrated H₂SO₄, treated with EtNO₃ at 0°, gives a crystalline precipitate of 2-chloro-6-nitrobenzothiazole (IV), m. 192°, which at 140° (under pressure) with alc. NH₃ gives 2-amino-6-nitrobenzothiazole (V), yellow, m. 245° (alc.), identical with the compound obtained by treating p-nitro-aniline with NH₄CNS (cf. Kauffmann, C.A. 29, 2660.1). IV with Br in CHCl₃ gives 2-chloro-6-bromobenzothiazole, white, m. 100-1°, and the same compound is obtained by treating the diazo derivative of IV with Cu₂Br₂. The structure of I according to Bonino shows the pyridine-like character of the N atom, and the strictly aromatic character of the benzene nucleus; however, in this nucleus the tricentered bond is fixed, while in other nuclei it is of an oscillating type, as in the equilibrium of quinoline: (VI)⇌ (VII). In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4HPLC of Formula: 80945-86-4).

6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.HPLC of Formula: 80945-86-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors was written by Gao, Ping;Wang, Xueshun;Sun, Lin;Cheng, Xiqiang;Poongavanam, Vasanthanathan;Kongsted, Jacob;Alvarez, Mar;Luczkowiak, Joanna;Pannecouque, Christophe;De Clercq, Erik;Lee, Kuo-Hsiung;Chen, Chin-Ho;Liu, Huiqing;Menendez-Arias, Luis;Liu, Xinyong;Zhan, Peng. And the article was included in Chemical Biology & Drug Design in 2019.Recommanded Product: 69812-29-9 This article mentions the following:

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated RNase H (RNase H) remains as the only enzyme encoded within the viral genome not targeted by current antiviral drugs. In this work, we report the design, synthesis, and biol. evaluation of a novel series of galloyl derivatives with HIV-1 RNase H inhibitory activity. Most of them showed IC₅₀s at sub- to low-micromolar concentrations in enzymic assays. The most potent compound was II-25 that showed an IC₅₀ of 0.72 ± 0.07 μM in RNase H inhibition assays carried out with the HIV-1_BH10 RT. II-25 was 2.8 times more potent than β-thujaplicinol in these assays. Interestingly, II-25 and other galloyl derivatives were also found to inhibit the HIV IN strand transfer activity in vitro. Structure-activity relationships (SAR) studies and mol. modeling anal. predict key interactions with RT residues His539 and Arg557, while providing helpful insight for further optimization of selected compounds In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Recommanded Product: 69812-29-9).

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 69812-29-9

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Visible-Light-Driven Synthesis of 4-Alkyl/Aryl-2-Aminothiazoles Promoted by In Situ Generated Copper Photocatalyst was written by Lei, Wen-Long;Wang, Tao;Feng, Kai-Wen;Wu, Li-Zhu;Liu, Qiang. And the article was included in ACS Catalysis in 2017.Electric Literature of C15H12N2S This article mentions the following:

Aryl- and alkyl-substituted 2-aminothiazoles were prepared chemoselectively by photochem. cyclocondensation of vinyl azides with ammonium thiocyanate in the presence of Cu(OAc)₂ under blue (visible) light LED irradiation at ambient temperature The mechanism of the cyclocondensation was studied; bis(thiocyanato)copper(I) anion generated in situ acted as both a catalyst for photochem. generation of azirines from vinyl azides and for ring opening of the azirines with thiocyanate. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Electric Literature of C15H12N2S).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Electric Literature of C15H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of 2-Aminobenzothiazoles via Copper(I)-Catalyzed Cross-Coupling with Part-Per-Million Catalyst Loadings was written by Sun, Ya-Lei;Zhang, Yuan;Cui, Xiao-Hui;Wang, Wei. And the article was included in Advanced Synthesis & Catalysis in 2011.Product Details of 1843-21-6 This article mentions the following:

An efficient protocol has been developed for the preparation of 2-aminobenzothiazoles via a copper(I)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates at very low catalyst loadings [typically 50 ppm of copper(I) iodide (CuI)]. A variety of 2-iodoanilines could be cross-coupled with isothiocyanates, affording 2-aminobenzothiazoles in moderate to good yields (49-93%) under the given conditions. The turnover number (TON) of this reaction reaches 67,000 and the reaction could be scaled up, at least, to the gram-scale. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Product Details of 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Product Details of 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica