Tag: 200-300

On June 28, 2011, Biedermann, Frank; Appel, Eric A.; del Barrio, Jesus; Gruendling, Till; Barner-Kowollik, Christopher; Scherman, Oren A. published an article.Product Details of 92-36-4 The title of the article was Postpolymerization Modification of Hydroxyl-Functionalized Polymers with Isocyanates. And the article contained the following:

The postpolymn. functionalization of hydroxyl-group terminated polymers (Mn in the range of 1000-6000 g mol-1) such as poly(ethylene glycol) (PEG), poly(N-isopropylacrylamide) (PNIPAM), poly(N,N-dimethylacrylamide) (PDMAM), and poly(tert-Bu acrylate) (PtBA) with a wide range of functional isocyanate derivatives such as azobenzene, viologen, and anthracene was studied. It was shown by 1H and 13C NMR, GPC, Fourier transform IR spectroscopy (FTIR), and electrospray ionization mass spectrometry (ESI-MS) that a high degree of end-group conversion, typically >98%, with little or no formation of side products can be achieved at ambient temperature PNIPAM, PDMAM, PtBA, and PHEAM polymers were obtained by reversible addition-fragmentation chain transfer (RAFT) radical polymerization from a hydroxyl-group containing chain transfer agent (CTA). The formation of the carbamate was compatible with the trithiocarbonate end-group of the RAFT polymers. Addnl., this approach allows for the direct functionalization of RAFT polymers without the need of addnl. steps such as deprotection or aminolysis of the CTA. This route was subsequently used for the preparation of a variety of side-chain functional polymers from poly(N-hydroxyethyl acrylamide) (PHEAM). Three different high yielding methods were employed to prepare the isocyanates (R-NCO). Either amino or carboxylic acid precursors were converted into the desired R-NCO or hydroxyl group moieties were reacted with an excess of 1,6-hexamethylene diisocyanate (HDI) to statistically form the monofunctional product. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Product Details of 92-36-4

The Article related to postpolymn modification hydroxyl functionalized polymer isocyanate carbamate, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Product Details of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2007, Ukrainets, I. V.; Mospanova, E. V.; Sidorenko, L. V. published an article.Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was 4-hydroxy-2-quinolones. 122. 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides as potential antitubercular agents. And the article contained the following:

An improved method is reported for the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides, e.g., I. The antitubercular activity of all of the compounds prepared has been studied. The structure-biol. activity dependence revealed is discussed. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to hydroxyoxodihydropyrroloquinoline carboxylic acid heteroaryl amine amidation, pyrroloquinoline amide hydroxyoxodihydro derivative preparation tuberculostatic activity, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2011, Hathoot, A. A.; El-Maghrabi, S.; Abdel-Azzem, M. published an article.Recommanded Product: 92-36-4 The title of the article was Electrochemical and electrocatalytic properties of hybrid films composed of conducting polymer and metal hexacyanoferrate. And the article contained the following:

Hybrid organic/inorganic modified electrode, composed of poly(2-(4-aminophenyl)-6-methylbenzothiazole) (PABT) matrix and Prussian blue (PB) like Ni hexacyanoferrate redox centers (PABT/NiHcF), showed reversible electrochem. behavior in aqueous electrolytes. Pt disk (Pt) was used as a conductive substrate onto which the composite film was electrodeposited by potential cycling. Electrochem. behavior of the modified electrode was well characterized using cyclic voltammetry (CV). The voltammetric characteristics of the composite modified electrodes were also studied in presence of different alkali metal cations (Li+, Na+, K+ ,Ce+ and NH4+). The heterogeneous electron transfer processes involving the composite and their stability were examined by subjecting the system to the long term cyclic voltammetric potential, cycling in 0.2 M NaCl electrolyte. Bilayer composite electrodes exhibit higher ionic conductivity, higher stability in comparison with pure inorganic (MeHcF) films. The inner electro active polymer chains in the film cause enhancement in the elec. conductivity of the composite electrodes. The modified electrode presented a good electrocatalytic activity towards the oxidation of MeOH, and oxalic acid (COOH)2. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Recommanded Product: 92-36-4

The Article related to electrochem electrocatalysis hybrid film composed conducting polymer metal hexacyanoferrate, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Recommanded Product: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2007, Zheng, Ming-Qiang; Yin, Duan-Zhi; Shen, Yu-Mei; Li, Gu-Cai published an article.Related Products of 92-36-4 The title of the article was Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and determination of their activity as PET tracers for human brain β-amyloid peptides. And the article contained the following:

A series of novel 2-(4-aminophenyl)-6-substituted benzothiazole derivatives were prepared and evaluated as potential β-amyloid PET (positron emission tomog.) tracers. Were prepared from proper 2-amino-6-substituted benzothiazole derivatives through basic hydrolysis, intermol. cycloaddition and N/O-alkylation reactions. Their structures were confirmed by IR, 1H NMR, EI/ESI-MS, HRMS spectra and elemental anal. The sequence of binding affinity of some compounds with human brain homogenate was analyzed. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Related Products of 92-36-4

The Article related to benzothiazolyl benzenamine preparation pet tracer brain amyloid, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2015, Lei, Yingjie; Wu, Xinshi; Zhang, Guochun; Ai, Cuiling published an article.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Synthesis of 2-(4-aminophenyl)benzothiazoles using MF resin supported H+ under solvent free conditions. And the article contained the following:

A simple and convenient approach to 2-(4-aminophenyl)benzothiazole derivatives by condensation of o-aminothiophenol with (un)substituted p-aminobenzoic acid under the action of melamine formaldehyde resin (MFR) supported sulfuric acid under microwave irradiation (MW) and solvent-free conditions has been developed. Structures of the corresponding products were elucidated by IR, 1H NMR spectra, and elemental anal. The resin could be easily recovered and reused for subsequent reactions. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to aminophenyl benzothiazole preparation, aminothiophenol amino benzoic acid melamine formaldehyde resin cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ma, Dawei; Xie, Siwei; Xue, Peng; Zhang, Xiaojing; Dong, Jinhua; Jiang, Yongwen published an article in 2009, the title of the article was Efficient and economical access to substituted benzothiazoles: copper-catalyzed coupling of 2-haloanilides with metal sulfides and subsequent condensation.SDS of cas: 92-36-4 And the article contains the following content:

The first metal-catalyzed direct coupling of metal sulfides with aryl halides and subsequent intramol. condensation provided substituted benzothiazoles. A wide range of functional groups are tolerated under the reaction conditions. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).SDS of cas: 92-36-4

The Article related to benzothiazole derivative preparation, haloanilinde metal sulfide coupling copper cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 8, 2006, Jeppesen, Lone; Kristiansen, Marit published a patent.Formula: C7H10N2O2S2 The title of the patent was Preparation of N-heteroaromatic propionamides as glucokinase activators for treating diabetes and other diseases. And the patent contained the following:

The present invention describes 2,3-di-substituted N-heteroaromatic propionamides of Formula I ( wherein the * indicates an asym. atom; R1,R2 = H, halo, NH2, NHOH, C1-6 alkyl, perfluoro-C1-6 alkyl, etc.; R3 = C3-7 cycloalkyl and C2-4 alkyl; ring A = a monosubstituted or a disubstituted 5-6 membered heteroaromatic ring consisting of, in addition to the C=N shown, carbon atoms and 0-2 heteroatoms selected from S(O)p, 0, and N; p= 0-2) pharmaceutical compositions comprising the same; and, methods of using the same. The propionamides are glucokinase activators for the treatment II diabetes and other disorders(no data given). The preparation of I is exemplified. For example, II was prepared in 2 steps by reacting intermediate 2-amino-5-(4-methylpiperazin-1-yl)thiazole (preparation given) with 3-cyclopentyl-2-(4-methanesulfonylphenyl)propionic acid. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Formula: C7H10N2O2S2

The Article related to heteroaromatic propionamide preparation glucokinase activator diabetes treatment, metabolic disorder treatment heteroaromatic propionamide glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C7H10N2O2S2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 3, 2012, Jeppesen, Lone; Kristiansen, Marit published a patent.Quality Control of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Heteroaromatic glucokinase activators. And the patent contained the following:

The present invention describes 2,3-di-substituted N-heteroaromatic propionamides, of Formula (I) wherein the substitution at the 3-position is an optionally substituted Ph ring and the substitution at the 2-position is an alkyl or cycloalkyl group; pharmaceutical compositions comprising the same; and, methods of using the same. The propionamides are glucokinase activators for the treatment of type II diabetes. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Quality Control of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to heteroaromatic propionamide preparation glucokinase activator diabetes treatment, metabolic disorder treatment heteroaromatic propionamide glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 2, 2013, Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde published an article.Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki-Miyaura cross-coupling reactions. And the article contained the following:

In positron emission tomog. [11C]PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer’s disease. Synthetic routes for the preparation of the precursor of [11C]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple 1-step synthesis of the precursor of [11C]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [18F] precursor derivatives of PIB containing a nitro function. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to pittsburgh compound b pet tracer precursor alzheimer diagnosis preparation, benzothiazole pittsburgh b pet tracer precursor alzheimer diagnosis preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2022, Cai, Mingzhong; Ye, Qian; Huang, Wencheng; Hao, Wenyan published an article.SDS of cas: 92-36-4 The title of the article was Recyclable copper-catalyzed cyclization of o-haloanilides and metal sulfides: An efficient and practical access to substituted benzothiazoles. And the article contained the following:

An efficient heterogeneous copper-catalyzed cyclization of o-haloanilides and metal sulfides has been achieved via the C-S coupling in DMF at 80 or 140° in the existence of an MCM-41-bound NHC-Cu(I) catalyst and then intramol. condensation, delivering a wide range of substituted benzothiazoles in mostly good to high yields. This new MCM-41-NHC-CuI complex can facilely be obtained by a two-step procedure starting from easily accessible and inexpensive reagents and reused more than seven times without any significant loss of its catalytic efficiency. The present protocol has been successfully applied to the gram-scale synthesis of two antitumor agents 5F203 and PMX 610. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).SDS of cas: 92-36-4

The Article related to benzothiazole preparation green chem, haloanilide metal sulfide cross coupling intramol condensation, mesoporous silica mcm 41 anchored nhc copper complex, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica