With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-03-6,2-Amino-5-bromobenzothiazole,as a common compound, the synthetic route is as follows.
A mixture of 5-bromo-1,3-benzothiazol-2-amine (200 mg, 0.87 mmol, 1.0 eq.) and 4-nitrophenyl 5?bromo-2-hydroxybenzoate (325 mg, 0.96 mmol, 1.1 eq.) was melted at 200¡ãC for 80 minutes. The solid was taken up in ethanol and heated at reflux temperature during 20 minutes. The solid product was filtered and then, triturated with diethyl ether to afford26bas an off-white solid (160 mg, 43 percent).1H NMR(DMSO-d6, 600 MHz):d(ppm): 7.03 (1H, d, J3-4= 8.7Hz, H3), 7.52 (1H, dd, J6?-7?= 8.5Hz, J6?-4?= 1.4Hz, H6?), 7.64 (1H, dd, J4-3= 8.7Hz, J4-6= 2.3Hz, H4), 7.94 (1H, bs, H4?), 8.00 (1H, d, J7?-6?= 8.5Hz, H7?), 8.04 (1H, d, J6-4= 2.3Hz, H6), 12.25 (1H, bs, amide H).13C NMR (DMSO-d6, 150 MHz):d(ppm): 111.0 (C5), 119.7 (C5?), 119.9 (C7a?), 120.1 (C3), 124.5 (C7?), 127.1 (C6?), 132.8 (C6), 137.3 (C4).HRMS calcd for C14H979Br81Br N2O2S: m/z = 428.8726, found: 428.8774.
The synthetic route of 20358-03-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Labriere, Christophe; Gong, Huansheng; Finlay, B. Brett; Reiner, Neil E.; Young, Robert N.; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1 – 13;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica