Tag: 22900-83-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Example 26Ethy[ 2- ({4-[(2-ethy[pheny[)carbamoy[]-3-methy[- 1 ,2-thiazo[-5-y[lamino)-4-methy[- 1 ,3-thiazo[e-5-carboxy[ate A mixture of 5-amino-N-(2-ethy[pheny[)-3-methy[-1 ,2-thiazo[e-4-carboxamide [Intermediate 1] (180 mg, 0.69 mmo[, 1.0 eq), ethy[ 2-bromo-4-methy[-1,3- thiazo[e-5-carboxy[ate [CAS-RN: 22900-83-0] (207 mg, 0.83 mmo[, 1.2 eq) and cesium carbonate (516 mg, 1.58 mmo[, 2.3 eq) in 5.7 mL dioxane/DMF (7/1) was p[aced in a microwave via[ and f[ushed with argon. Then, pa[[adium(II) acetate(15 mg, 0.07 mmo[, 0.1 eq) and Xantphos (40 mg, 0.07 mmo[, 0.1 eq) were added. The via[ was capped and the reaction mixture was stirred at an environmenta[ temperature of 110 ¡ãC overnight. On coo[ing, the reaction mixture was partitioned between dich[oromethane and water. After fi[tration over Ce[ite, the organic phase was separated and concentrated in vacuo. The crude product was crysta[[ised fromdiethy[ ether and washed subsequent[y with a sma[[ portion of ethy[ actetate to give 116 mg (40percent yie[d of theory) of the tit[e compound in 99percent purity (LC-MS area-0/0UPLC-MS (Method 1): R = 1.55 mm; MS (Elneg) m/z = 429 [M-H].1HNMR (400 MHz, DMSO-d6): oe [ppm] = 1.12-1.34 (m, 3H), 1.25 (t, 3H), 2.59 (s,3H), 2.53-2.85 (m, 5H), 4.22 (q, 2H), 7.06 (s br, 1H), 7.18 (t, 1H), 7.24 (d, 1H),8.30 (d, 1H), 11.70 (s br, 1H).

The synthetic route of 22900-83-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; PRECHTL, Stefan; SIEMEISTER, Gerhard; WENGNER, Antje Margret; ACKERSTAFF, Jens; NOWAK-REPPEL, Katrin; BADER, Benjamin; LIENAU, Philip; STOeCKIGT, Detlef; WO2014/118186; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

22900-83-0, Ethyl 2-bromo-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-aminothiophenol (1.25 g, 10.0 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (2.75 g, 11.0 mmol) and potassium carbonate (1.52 g,11.0 mmol) in acetonitrile (10 mL) was heated to 80 ¡ãC and stirred for 20 hours under an N2 atmosphere. The reaction mixture was then cooled to rt. The resulting mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as a white solid (1.0 g,34.0percent). The compound was characterized by the following spectroscopic data:LC-MS (ESI, pos. ion) m/z: 295.1 [M + H] and?H NMR(400 MHz, CDC13) (ppm): 7.46 (d, J = 8.4 Hz, 2H), 6.77 (d, J = 8.4 Hz, 2H), 4.25 (q, J 7.2 Hz, 2H), 2.67 (s, 3H), 1.30 (d, J 7.2 Hz, 3H).

As the paragraph descriping shows that 22900-83-0 is playing an increasingly important role.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; CHENG, Changchung; WO2015/169180; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica