Tag: 2516-40-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2516-40-7,2-Bromobenzothiazole,as a common compound, the synthetic route is as follows.

9-Ethyl-3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -9H-carbazole (1 g, 3.1 mmol) is dissolved in the THF (20 mL). 2-bromobenzothiazole (0.663 g, 3.1 mmol), Pd (PPh3) 4 (0.179 g, 0.155 mmol), Na2CO3 (0.985 g, 9.3 mmol) and distilled water (4 mL) was added a After 15 hours the 70 degree in a nitrogen atmosphere heated at. After the reaction mixture was poured into distilled water (300 mL) Separate the organic layer with ethyl acetate, dry over MgSO4 and evaporate solvents. Column with ethyl acetate / hexane: separate the compound (3) by the (1 2) as a developing solvent to obtain the compound (2) to 65percent.

As the paragraph descriping shows that 2516-40-7 is playing an increasingly important role.

Reference£º
Patent; Pusan National University Industry-Academic Cooperation Foundation; Jin, Sung Ho; Park, Jin Soo; (26 pag.)KR101481147; (2015); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2516-40-7, 2-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Chlorobenzothiazole(169 mg, 1 mmol) and EtOH (5 ml), and 3-fluoro-4-hydroxyaniline (127 mg, 1 mmol) was dissolved in and p-TsOH*H2O (30.4 mg, 0.1 mmol) was added and the mixture was stirred for 4 hours at 80 ¡ã C. After checking the completion of the reaction, then cooled at room temperature, then evaporated under reducedpressure to remove the solvent. The concentrated residue was extracted with ethyl acetate (5 ml) and water (3 x 3ml). The extractedorganic layer was filtered and then dried over anhydrous magnesium sulfate, the reduced pressure of the filtrate was evaporated,and purified by column chromatography, and diluted with an equal volume of HCl solution and dried. As a result, 4-(benzo[d]thiazol-2-ylamino)-2-fluorophenol was obtained (222 mg, 75percent yield).

The synthetic route of 2516-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gyeonggi Science & Technology Agency; Koo, Jin Moh; Jung, Kwi Wan; Kim, Soo Mi; Park, Jong Hyun; Noh, Jae Sung; Lee, Jung Heon; Park, Sun Min; Jung, Dae Yeon; Lee, Kwang Nyung; Choe, Joo Hyung; (36 pag.)KR101659952; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2516-40-7, 2-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2- (3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) imidazo [1,2- a] pyridine 200 mg, 0.580 mmol) was added Palladium acetate (6 mg, 0.03 mmol),Triphenylphosphine (30 mg, 0.12 mmol),Sodium carbonate (124 mg, 1.16 mmol) was added, Dioxane and water in a ratio of 1: 1 in an amount of 5 mL,2-Bromobenzothiazole (124 mg, 0.580 mmol) was added,Stir at 90 ¡ã C under nitrogen gas.After the reaction is completed, the reaction mixture is cooled to room temperature. The reaction mixture is separated into water and ethyl acetate, and the extracted organic layers are combined and washed with water. After drying with magnesium sulfate, the mixture was concentrated and the concentrate was purified by silica gel column chromatography (dichloromethane: ethyl acetate, 20: 1 v / v)To obtain 2- (3- (benzothiazol-2-yl) phenyl) -8-cyanoimidazo [1,2-a] pyridine (98 mg, 59percent).

2516-40-7 2-Bromobenzothiazole 612040, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Jeon Mun-guk; Kim Gwang-rok; Huh Yun-jeong; Lee Jun-mi; (27 pag.)KR2018/101671; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica