Tag: 297.3533

Uno, Toyozo et al. published their research in Yakugaku Zasshi in 1960 | CAS: 127-76-4

N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Synthetic Route of C11H11N3O3S2

Metabolism of sulfathiazole. I. Excreted substance in human urine after administration of sulfathiazole was written by Uno, Toyozo;Ueda, Michihiro. And the article was included in Yakugaku Zasshi in 1960.Synthetic Route of C11H11N3O3S2 This article mentions the following:

The urine during oral administration of sulfathiazole (I) was examined by paper chromatography, using neutral, acid, and alk. developing solvents and by paper electrophoresis. I, acetylsulfathiazole (II), sulfathiazole N4-sulfonate, sulfathiazole N4-glucuronide, and an unknown substance (III) were detected. These products, except the III, were compared with authentic samples. In another experiment I, II, and an unknown glucuronic acid conjugate were isolated but no other substances. A new and simple apparatus for two-dimensional, ascending paper chromatography was devised, in which the filter paper was wrapped in a plastic sheet. In the experiment, the researchers used many compounds, for example, N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4Synthetic Route of C11H11N3O3S2).

N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Synthetic Route of C11H11N3O3S2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bellen, Z. et al. published their research in Chemia Analityczna (Warsaw, Poland) in 1956 | CAS: 127-76-4

N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Product Details of 127-76-4

Determination of 2-[bis-(N-acetylsulfanilyl)]aminothiazole in the commercial product was written by Bellen, Z.;Mroczkowska, Z.. And the article was included in Chemia Analityczna (Warsaw, Poland) in 1956.Product Details of 127-76-4 This article mentions the following:

The method consists of ammonolysis of the product by heating with concentrated NH3 and EtOH and by double evaporation of EtOH and NH3. Acetyl sulfathiazole is determined by potentiometric titration in H2OMe2CO mixture (4:1) with standard NaOH solution The determination of impurities in the sample is analogous. The results are tabulated and given in graphs. The method gave good results for pure as well as for com. samples. In the experiment, the researchers used many compounds, for example, N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4Product Details of 127-76-4).

N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Product Details of 127-76-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica