Tag: 300-400

The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling was written by Cupido, Tommaso;Rack, Paul G.;Firestone, Ari J.;Hyman, Joel M.;Han, Kyuho;Sinha, Surajit;Ocasio, Cory A.;Chen, James K.. And the article was included in Angewandte Chemie, International Edition in 2009.Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine The following contents are mentioned in the article:

Eradicating hedgehogs: The title mol. has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This mol. is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine).

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A small-molecule antagonist of the Hedgehog signaling pathway was written by Lee, Jongkook;Wu, Xu;Pasca di Magliano, Marina;Peters, Eric C.;Wang, Yan;Hong, Jiyong;Hebrok, Metthias;Ding, Sheng;Cho, Charles Y.;Schultz, Peter G.. And the article was included in ChemBioChem in 2007.SDS of cas: 315703-52-7 The following contents are mentioned in the article:

Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chem. libraries. Results from biochem. and cellular experiments suggest that JK184 functions by inhibiting ge. This mol. should serve as a useful tool for studying Hedgehog signaling. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7SDS of cas: 315703-52-7).

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 315703-52-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pickering emulsions stabilized by ultrashort nanotubes was written by Meng, H.;Du, D.. And the article was included in Materials Today Chemistry in 2021.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

We describe a simple method to prepare high-efficiency ultrashort nanotube Pickering emulsifiers. The polydivinylbenzene (PDVB) nanotubes with a slight degree of sulfonation, then interrupted to several microns in length, can stabilize hundred times their own mass of oil or water phase and form different Pickering emulsion types. The emulsion is very stable and can be stored for more than half a year without demulsification. A layer of magnetic Fe₃O₄ nanoparticles can be grown on the surface of the ultrashort sulfonated PDVB nanotubes. After being emulsified, oil-phase and magnetic nanotubes can be collected using a magnet, which have huge potential application for separation and recovery of organic solvents in environmental protection. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tumour suppressor p53 inhibits hepatitis C virus replication by inducing E6AP -mediated proteasomal degradation of the viral core protein was written by Park, Ji-Min;Yoon, Hyunyoung;Jeong, Yuna;Jang, Kyung Lib. And the article was included in FEBS Letters in 2022.HPLC of Formula: 63208-82-2 The following contents are mentioned in the article:

The tumor suppressor p53 has been implicated in the host defense system against hepatitis C virus (HCV) infection, although the detailed mechanism remains unknown. Here, we found that p53 inhibits HCV replication by downregulating HCV Core protein levels in human hepatoma cells. For this effect, p53 potentiated the role of E6-associated protein (E6AP) as an E3 ligase to induce ubiquitination and proteasomal degradation of HCV Core. Specifically, p53 facilitated the binding of E6AP to HCV Core through direct interactions with the two proteins. In addition, E6AP failed to induce ubiquitination of HCV Core in the absence of p53, suggesting that p53 increases the E3 ligase activity of E6AP in a triple complex consisting of p53, E6AP and HCV Core. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2HPLC of Formula: 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.HPLC of Formula: 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

P53-induced reduction of lipid peroxidation supports brain microvascular endothelium integrity was written by Akhter, Mohammad S.;Uddin, Mohammad A.;Kubra, Khadeja-Tul;Barabutis, Nektarios. And the article was included in Journal of Pharmacological Sciences in 2019.Formula: C16H19BrN2OS The following contents are mentioned in the article:

Dysregulation of the blood brain barrier due to oxidative stress causes neurol. disorders, such as Alzheimer′s and Parkinson′s disease. We employed brain microvascular endothelial cells; to investigate the effects of P53 towards the lipid oxidation of the BBB. P53 reduction by LPS, siRNA for P53 and Pifithrin increased the expression levels of malondialdehyde, a marker of oxidative stress and lipid peroxidation Furthermore, P53 suppression impaired the permeability of the BBB monolayers. In contrast, P53 induction by Nutlin and Hsp90 inhibitor AUY922 enhanced the BBB function. In conclusion, P53 supports BBB integrity, at least in part, by reducing lipid peroxidation This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Formula: C16H19BrN2OS).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Formula: C16H19BrN2OS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Signal transmission encryption based on dye-doped chiral liquid crystals via tunable and efficient circularly polarized luminescence was written by Li, Chengxi;Yang, Xuefeng;Han, Jianlei;Sun, Wenjing;Duan, Pengfei. And the article was included in Materials Advances in 2021.Recommanded Product: 38215-36-0 The following contents are mentioned in the article:

Multi-channel adjustable chiral liquid crystal materials with outstanding circularly polarized luminescence (CPL) have attracted lots of interest. Here, we demonstrate a coumarin 6 (C6) doped chiral liquid crystal, exhibiting crosstalk-free tunable CPL behavior by adjusting the component ratio and thickness. In the thickness study, when a double-layer structure was implemented, excellent CPL performance with a large dissymmetry factor (1.53) was observed in an optimal ratio. In particular, a rare chiroptical device using the obtained CPL as the input signal source was built to encrypt the signal transmission. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Recommanded Product: 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Coumarins with highly stokes shifted absorption and emission was written by Sekar, N.. And the article was included in Colourage in 2022.Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

Fluorescent chromophores with long-wavelength emission has arisen in conjunction with single-mol. spectroscopy of biomols. where most traditional dyes lack the required fluorescence quantum yield and photostability or whose performance is hampered by aggregation of their extended-conjugated cores. Fluorescence imaging of single mols. is a powerful technique in which subtle characteristics of the structure and dynamics of complex condensed materials are revealed that are otherwise hidden in ensemble measurements. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor was written by Romeo, Maria Anele;Gilardini Montani, Maria Saveria;Benedetti, Rossella;Arena, Andrea;D’Orazi, Gabriella;Cirone, Mara. And the article was included in International Journal of Molecular Sciences in 2022.Related Products of 63208-82-2 The following contents are mentioned in the article:

HDAC inhibitors (HDACi) represent promising anti-cancer treatments, as the acetylation of histone and non-histone proteins is often dysregulated in cancer and contributes to cancer onset and progression. HDACi have been also reported to increase the cytotoxicity of DNA-damaging agents, such as radiation or cisplatin. In this study, we found that TSA and, even more effectively, VPA synergized with AZD2461, PARP1, 2 and 3 inhibitor (PARPi) to induce DNA damage and reduce pancreatic cancer cell survival. At a mol. level, VPA and TSA down-regulated CHK1 and RAD51, which is correlated with the interruption of the cross-talk between mutp53 and HSP70. Moreover, VPA and to a lesser extent TSA reactivated wtp53 in these cells, which contributed to CHK1 and RAD51 reduction These findings suggest that the combination of HDACi and PARPi might improve the treatment of pancreatic cancer, which remains one of the most aggressive and therapy-resistant cancers. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Related Products of 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Related Products of 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Age-related dysfunction of p53-regulated phagocytic activity in macrophages was written by Yamaguchi, Yohko;Kaida, Kohei;Suenaga, Yusuke;Ishigami, Akihito;Kobayashi, Yoshiro;Nagata, Kisaburo. And the article was included in Biochemical and Biophysical Research Communications in 2020.Related Products of 63208-82-2 The following contents are mentioned in the article:

Aging promotes polarization of M2-like macrophages to M1-like macrophages and reduces their phagocytic ability. However, the mol. mechanisms underlying these aging-related changes remain poorly understood. Here, we demonstrate that p53 regulates phagocytic activity in macrophages from young mice but not in those from old ones. Macrophages from both old and young mice expressed functional p53 to induce target genes including p21 and Mdm2. In macrophages from young mice, chem. induced p53 decreased phagocytic activity and c-Myc levels, with the latter change reducing M2-related genes. However, in macrophages from old mice, phagocytic activity and c-Myc expression were independent of p53 activity. Furthermore, c-Myc suppression did not affect M2-related genes in old-mouse macrophages. These results demonstrate that dysregulation of p53 function is a mol. mechanism underlying reduced phagocytic activity in aged-mouse macrophages. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Related Products of 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Related Products of 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tailoring C-6-Substituted Coumarin Scaffolds for Novel Photophysical Properties and Stimuli-Responsive Chromism was written by Singh, Ravinder;Chen, Deng-Gao;Wang, Chun-Hsiang;Lan, Yi-Cheng;Liu, Yi-Hung;Chou, Pi-Tai;Chen, Chao-Tsen. And the article was included in Journal of Physical Chemistry B in 2021.COA of Formula: C20H18N2O2S The following contents are mentioned in the article:

A judicious strategy was utilized to envision the substantial regio-positional effects of substituents on the photophys. properties of the 2H-chromen-2-one-3-benzothiazole scaffold-based push-pull framework, named 6-X-CUMs. Among them, 6-NEt₂-CUM reveals prominent excited-state intramol. charge transfer with a large change of dipole moment (Δμ ~18.23 D), hence displaying remarkable emission solvatochromism from the green (536 nm in cyclohexane) to far-red region (714 nm in DMSO) and a high-temperature sensitivity (-0.23 nm °C^-1). These, together with unique basicity and acido-/vaporchromism upon acidification elucidated by NMR and photospectroscopic studies, show stark contrast to the conventional 7-NEt₂-CUM. The new series of these tailored 6-X-CUMs represents a new dimension in tailoring the photophys. properties for the development of a promising class of multistimuli-responsive materials. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0COA of Formula: C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.COA of Formula: C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica