Tag: 300-400

On July 5, 2018, Ma, Chunhua; Miao, Yuqi; Zhao, Minghao; Wu, Ping; Zhou, Jianglu; Li, Zhi; Xie, Xilei; Zhang, Wei published an article.Recommanded Product: 31699-14-6 The title of the article was Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydantoin (DBH). And the article contained the following:

An efficient procedure for the synthesis of 2-aminothiazoles via DBH-mediated oxidative cyclization of styrenes and thioureas is reported. Various alkenes were successfully transformed to the corresponding 2-aminothiazoles in yields of 10-81% via a two-step one-pot manner using DBH as both the bromine source and oxidant. The method can be readily carried out in gram-scale and successfully applied to the synthesis of anti-inflammatory drug fanetizole using styrene as starting material. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Recommanded Product: 31699-14-6

The Article related to aminothiazole preparation, styrene thiourea oxidative cyclization dibromo dimethylhydantoin, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 27, 2022, Wang, Xingyi; Zhu, Yue; Zhou, Tingting; Yang, Weiqing; Fu, Haiyan; Chen, Hua; Ma, Menglin published an article.Application of 31699-14-6 The title of the article was Bromine-Mediated C-S Bond Formation: Synthesis of Thiazoles from α-Methylene Ketones by Using Oxone Oxidative System. And the article contained the following:

A novel method for the synthesis of various 2,4,5-trisubstituted thiazoles from methylketones and thiourea/thioacetamide/amidinothiourea using NaBr/Oxone oxidative system was developed. The three intimately connected advantages of this method, which form a whole, are that the reaction underwent a one-pot α-bromination/cyclization process, the use of more common methylene ketones as the raw material rather than α-halomethylene ketones and a cheap and easily available catalytic amount sodium bromide as the bromine source instead of stoichiometric bromine or NBS. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Application of 31699-14-6

The Article related to ethanone methanethioamide sodium bromide catalyst one pot bromination heterocyclization, thiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2021, Ujwaldev, Sankuviruthiyil M.; Harry, Nissy Ann; Neetha, Mohan; Anilkumar, Gopinathan published an article.SDS of cas: 31699-14-6 The title of the article was Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation. And the article contained the following:

A novel iron-iodine catalyzed one pot synthesis of 2-aminothiazoles I (Ar = Ph, 4-bromophenyl, furan-2-yl, etc.; R = H, Ph) from Me aryl ketones ArC(O)Me and thioureas RNHC(S)NH2 is demonstrated. This protocol can be considered as a catalyzed version of the classical Hantzsch aminothiazole synthesis I as it enables the in situ generation of α-iodoketones in the reaction medium using catalytic amount of iodine leading to Hantzsch condensation with thiourea. The supply of iodine for multiple catalytic cycles is ensured by using catalytic amounts of iron as it enables iodide to iodine oxidation The generality of this protocol is also well established in this manuscript by synthesizing a variety of 2-aminothiazoles I from different ketones and thiourea. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).SDS of cas: 31699-14-6

The Article related to aminothiazole preparation green chem, methyl aryl ketone thiourea hantzsch condensation iron iodine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shibasaki, Kaho; Togo, Hideo published an article in 2019, the title of the article was 2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole And the article contains the following content:

Treatment of alkylarenes with N-bromosuccinimide in a mixture of Et acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of di-Et carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino-4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, resp., in one pot [e.g., ethylbenzene + thiourea → 2-amino-4-phenylthiazole (84%)]. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 20, 2018, Liessi, Nara; Cichero, Elena; Pesce, Emanuela; Arkel, Maria; Salis, Annalisa; Tomati, Valeria; Paccagnella, Matteo; Damonte, Gianluca; Tasso, Bruno; Galietta, Luis J. V.; Pedemonte, Nicoletta; Fossa, Paola; Millo, Enrico published an article.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole The title of the article was Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools. And the article contained the following:

The most common CF mutation, F508del, impairs the processing and gating of CFTR protein. This deletion results in the improper folding of the protein and its degradation before it reaches the plasma membrane of epithelial cells. Present correctors, like VX809 only induce a partial rescue of the mutant protein. Our previous studies reported a class of compounds, called aminoarylthiazoles (AATs), featuring an interesting activity as correctors. Some of them show additive effect with VX-809 (I) indicating a different mechanism of action. In an attempt to construct more interesting mols., it was thought to generate chem. hybrid compounds, blending a portion of VX-809 merged to the thiazole scaffold. This approach was guided by the development of QSAR analyses, which were performed based on the F508del correctors so far disclosed in the literature. This strategy was aimed at exploring the key requirements turning in the corrector ability of the collected derivatives and allowed us to derive a predictive model guiding for the synthesis of novel hybrids as promising correctors. The new mols. were tested in functional and biochem. assays on bronchial CFBE41o-cells expressing F508del-CFTR showing a promising corrector activity. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

The Article related to thiazole vx809 hybrid cystic fibrosis deletion mutation corrector qsar, aminoarylthiazole, cftr, corrector, cystic fibrosis, qsar, vx809, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2007, Karade, Hitendra; Sathe, Manisha; Kaushik, M. P. published an article.Name: 2-Amino-4-(4-iodophenyl)thiazole The title of the article was An efficient method for the synthesis of 2-aminothiazoles using silica chloride as a heterogeneous catalyst. And the article contained the following:

Preparation of 2-aminothiazoles under mild reaction conditions with quant. yields using silica chloride as an effective heterogeneous catalyst is reported. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Name: 2-Amino-4-(4-iodophenyl)thiazole

The Article related to aminothiazole preparation ketone thiourea silica chloride catalyst, thiazole amino preparation ketone thiourea silica chloride catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Name: 2-Amino-4-(4-iodophenyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2010, Gaikwad, Sudhakar A.; Patil, Amol A.; Deshmukh, Madhukar B. published an article.Electric Literature of 31699-14-6 The title of the article was An efficient, uncatalyzed, and rapid synthesis of thiazoles and aminothiazoles under microwave irradiation and investigation of their biological activity. And the article contained the following:

A convenient method for the synthesis of thiazoles by treatment of α-bromoketones with thioamides (Hantzsch synthesis) in the absence of catalysts under microwave irradiation was developed. The products were formed rapidly in excellent yields. An efficiency comparison of time, yield, and effort clearly proved the microwave technique to be superior. The structures of the newly synthesized compounds were characterized by spectroscopic data and elemental analyses. The synthesized compounds were tested for their biol. activity. Depending on the substituents, some of the thiazoles exhibit very good antibacterial or antifungal activity. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Electric Literature of 31699-14-6

The Article related to bromoketone hantzsch cyclization thioamide r microwave irradiation, thiazole preparation antibacterial antifungal activity, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2009, Muthuppalniappan, Meyyappan; Thomas, Abraham; Kumar, Sukeerthi; Margal, Sanjay; Khairatkar-Joshi, Neelima; Mukhopadhyay, Indranil; Gullapalli, Srinivas published a patent.Reference of 2-Amino-4-(4-iodophenyl)thiazole The title of the patent was Preparation of quinazolinedione derivatives as TRPA1 modulators. And the patent contained the following:

The title compounds I [ring A = (hetero)aryl, heterocyclyl, cycloalkyl; R1, R2 = H, OH, alkyl, etc.; R3, R4 = H, OH, halo, etc.; or R3 and R4 may be joined together to form (un)substituted 3-7 membered (un)saturated cyclic ring which may optionally include one or more heteroatom or group selected from O, S, C(O), S(O)0-2, (un)substituted NH; R5 = H, OH, alkyl, etc.; R6 = H, CN, NO2, etc.; n = 0-5], useful as TRPA (Transient Receptor Potential subfamily A) modulators for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1), were prepared E.g., a multi-step synthesis of II, starting from 2-amino-6-nitrobenzoic acid and urea, was given. Exemplified compounds I were screened for TRPA1 activity. For example, II showed 90.73% inhibition at 10.0 μM using the 45Calcium Uptake Assay. Also provided are processes for preparing compounds I, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Reference of 2-Amino-4-(4-iodophenyl)thiazole

The Article related to quinazolinedione preparation transient receptor potential channel trpa1 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Reference of 2-Amino-4-(4-iodophenyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 29, 2004, Vaccaro, Wayne; Yang, Bingwei Vera; Kim, Soong-hoon; Huynh, Tram; Tortolani, David R.; Leavitt, Kenneth J.; Li, Wenying; Doweyko, Arthur M.; Chen, Xiao-tao; Doweyko, Lidia published a patent.Recommanded Product: 31699-14-6 The title of the patent was Preparation of dibenzofused bicyclo[2.2.2]octane-derived amides as modulators of the glucocorticoid receptor. And the patent contained the following:

Title compounds I [R-R4 = H, alk(en/yn)yl, alkoxy, aryl, etc.; Z = carboxamido, alkylamino, etc.] are prepared For instance, 2-amino-4,5-dimethylthiazole is coupled to the acid derived from the cycloaddition of methacrylic acid and anthracene (CH3CN, EDCI, Et3N, HOAt, 18 h) to give II. I are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Recommanded Product: 31699-14-6

The Article related to modulator glucocorticoid receptor bicyclo amide preparation, Alicyclic Compounds: Bicyclic Compounds, Including Azulenes, Heptalenes, and Pentalenes and other aspects.Recommanded Product: 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 15, 2008, Yang, Bingwei Vera; Doweyko, Lidia M.; Vaccaro, Wayne; Huynh, Tram N.; Tortolani, David R.; Dhar, T.g. Murali published a patent.Name: 2-Amino-4-(4-iodophenyl)thiazole The title of the patent was N-Heteroaryl carboxamides as modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula I an enantiomer, diastereomer, tautomer, solvate (e.g. a hydrate), or a pharmaceutically-acceptable salt, thereof. Also provided are pharmaceutical compositions and methods of treating metabolic and inflammatory- or immune-associated diseases or disorders using said compounds Compounds of formula I wherein M is (un)substituted alkyl, cycloalkyl, (hetero)aryl and heterocyclyl; Ma and Za are independently a bond and C1-3 alkylene; Q is H, (un)substituted C1-4 alkyl; Q and R6 taken together to form a 3- to 6-membered cycloalkyl; Q and M taken together to form a 3- to 7-membered heterocyclic ring; Z is cycloalkyl, heterocyclyl and (hetero)aryl; R1 – R4 are independently H, halo, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, NO2, CN, OH and derivatives, etc.; R6 is (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, CHO, acyl, CO2H and derivatives, etc.; R7 is halo, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, NO2, CN, OH and derivatives, etc.; R22 is H, (un)substituted alkyl, CO-alkyl, CO2-alkyl, SO2-alkyl, alkoxy, (un)substituted amino, (hetero)aryl, heterocyclyl, and cycloalkyl; and their enantiomers, diastereoisomers, and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of 2,2-diphenyl-1-methylcyclopropane-1-carboxylic acid with 2-aminothiazole. All the invention compounds were evaluated for their GR and AP-1 modulatory activity. From the assay, it was determined that compound II exhibited Ki value of 103.8 % RBA. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Name: 2-Amino-4-(4-iodophenyl)thiazole

The Article related to heteroaryl carboxamide preparation glucocorticoid receptor ap1 nfkb modulator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 2-Amino-4-(4-iodophenyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica