With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3292-77-1,2-Bromo-1-(thiazol-2-yl)ethanone,as a common compound, the synthetic route is as follows.
2-Bromo-l-(l,3-thiazol-2-yl)ethanone (54.2 mg, 0.26 mmol) is added to a solution of (R)-quinuclidin-3-yl 2-(methyl(phenyl)amino)-2-phenylacetate (C75)(92.2 mg, 0.26 mmol) in EtOAc (5 mL). The mixture is stirred at RT overnight. The solvent is evaporated to dryness and the crude is triturated with Et2theta. The yellow solid is collected by filtration (120 mg, 82% yield, bromide salt, mixture of diastereoisomers).1H NMR (300 MHz, DMSO-^6) ppm: 8.39 (d, 1 H), 8.25 (d, 1 H), 7.32 – 7.50 (m, 5 H), 7.19 – 7.30 (m, 2 H), 6.84 – 7.00 (m, 2 H), 6.67 – 6.85 (m, 1 H), 5.97 (s, 1 H), 5.23 – 5.38 (m, 1 H), 5.19 and 5.20 (s, 2 H), 4.04 – 4.29 (m, 1 H), 3.44 – 3.82 (m, 5 H), 2.76 and 2.77 (s, 3 H), 2.24 – 2.36 (m, 1 H), 1.45 – 2.13 (m, 4 H); LC-MS (ESI POS): 476.0 (MH+).
3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various.
Reference£º
Patent; CHIESI FARMACEUTICI S.P.A.; CALIGIURI, Antonio; RICCABONI, Mauro; AMARI, Gabriele; WO2010/72338; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica