Tag: 34259-99-9

34259-99-9, 4-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pd(dppf)Cl2.CH2Cl2 (0.17 g, 0.0002 mole) was added to a stirred mixture of 4- bromothiazole (0.7 g, 0.004 mol), sodium carbonate ( 1.3 g, 0.012 mole) and 4-(4,4,5,5- tetramethyl-[l,3,2]dioxaborolan-2-yl)benzaldehyde (1.89 g, 0.008 mole) in a mixture of 1,4-dioxane and water (25 mL, 4: 1). The reaction mixture was heated to 80 ¡ãC and maintained for 6 hours, cooled to RT, diluted with H20 (10 mL), extracted with ethyl acetate (25 mL x 3). The organic extracts were combined, dried over anhydrous Na2S04 and concentrated under vacuum to obtain the crude 4-(thiazol-4-yl) benzaldehyde that was used as such for further reaction.

34259-99-9, 34259-99-9 4-Bromothiazole 2763218, athiazole compound, is more and more widely used in various.

Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; MOHAMMED, Abdul Rasheed; BADANGE, Rajesh Kumar; JAYARAJAN, Pradeep; BHYRAPUNENI, Gopinadh; JASTI, Venkateswarlu; (172 pag.)WO2018/42362; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

34259-99-9, 4-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1. 4-Neopentylthiazole. 4-Bromothiazole (1.98 g, 12.1 mmol) was covered with a 0.5 M solution of neopentylzinc iodide in THF (96 mL, 48.2 mmol). Pd2dba3.CHCI3 (624 mg, 0.603 mmol) and 2(-di-te/t-butylphosphine)biphenyl (720 mg, 2.41 mmol) were added and the reaction mixture was placed in an oil bath pre-heated to 70 ¡ãC. The resulting solution was allowed to stir for 24 h at 70 ¡ãC. The resulting mixture was cooled to room temperature and concentrated under vacuum and the residue was dissolved in ethyl acetate (100 mL) and subsequently washed with aqueous NaOH (2 x 40 mL, 3N). The organic phase was then dried (Na2SO4), filtered, concentrated under vacuum and the residue was purified on a silica gel column (eluant hexane to hexane/ethyl acetate 8/2) to give 4-neopentylthiazole (1.42 g, 75percent), retention time (min) = 1.198, method [1], MS(ESI) 156.1 (M+H).

As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; WO2007/47306; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica