Tag: 34272-64-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34272-64-5,2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 172 7-beta-Amino-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid 2.7 g (0.01 mole) of 7-aminocephalosporanic acid and 1.9 g (0.01 mole) of 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole are suspended in 250 ml of water. Sodium bicarbonate is added until a clear solution has formed. The reaction solution is heated to 50 C. for 4 hours, whilst keeping the pH value constant at the neutral point. The solution is allowed to cool and is extracted several times with ethyl acetate and the aqueous phase is adjusted to a pH value of 2 with 2 N HCl. The precipitate is filtered off, washed several times with alcohol and ether and dried. 3.7 g of the title compound of melting point 195-196 C. (decomposition) are obtained. NMR (d6 -DMSO, 60 MHz): delta=2.17 ppm (s, 3H, =C–CH3), delta=3.52 ppm (AB, 2H, 2–CH2 –), delta=3.68 ppm (s, 2H, =C–CH2 –COO–) delta=4.31 ppm (AB, 2H, 3–CH2 –S–) and delta=4.80 ppm (m, 2H, 6–CH–+7–CH–)., 34272-64-5

As the paragraph descriping shows that 34272-64-5 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US4278793; (1981); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

34272-64-5, 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Each resin from Step 3 was distributed into 24 fritted syringes (Torvig, 50 mg each, 50 mumol), for a total of 96 syringes, and was swelled in NMP (1 mL) for 30 min. The solvent was removed by filtration. Twenty-four solutions of the building blocks listed below (10 mmol each) and DIBA (3.5 mL, 20 mmol) in NMP (10 mL) were prepared. 3 mL of the 24 solutions was added to the 24 syringes for each resin from Step 3, accordingly. The suspensions were then shaken for 20 h on a Titer Plate Shaker. The reaction mixture was filtered and washed 5 times with methylene chloride (5 mL), 3 times with THF (5 mL), 3 times THF/H2O (3/1 v/v, 5 mL), and 3 times with THF (5 mL). The resins were then dried overnight under vacuum., 34272-64-5

34272-64-5 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid 3035180, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Kong, Xianqi; Wu, Xinfu; Valade, Isabelle; Gervais, Francine; US2006/167057; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica