With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-40-0,2-Bromo-4-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.
EXAMPLE 1 2-Bromo-4-chlorobenzothiazole (6.21 g, 0.025 mole) and 94% sodium hydroxide (1.57 g, 0.037 mole) were added to methanol (100 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 4.68 g of 2-methoxy-4-chlorobenzothiazole. Yield 93.8%, purity 99.3%, m.p. 55-57 C.
3622-40-0, 3622-40-0 2-Bromo-4-chlorobenzo[d]thiazole 77178, athiazole compound, is more and more widely used in various.
Reference£º
Patent; Sumitomo Chemical Company, Limited; US4293702; (1981); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica