Tag: 374.1725

Synthesis and in vitro antileishmanial activity of 5-substituted-2′-deoxyuridine derivatives was written by Peyron, Corinne;Benhida, Rachid;Bories, Christian;Loiseau, Philippe M.. And the article was included in Bioorganic Chemistry in 2005.Category: thiazole This article mentions the following:

We report herein the synthesis and the in vitro antileishmanial evaluation of 5-substituted-2′-deoxyuridine nucleosides. The most active compound against Leishmania donovani promastigotes was Thia-dU (3a) with an IC₅₀ = 3 渭M. This compound exhibited the same activity as zidovudine (3′-azido-2′-deoxythymidine) used as nucleoside reference compound Considering the cytotoxicity of synthetic compounds on peritoneal murine macrophages, the most toxic compound was MeThio-dU (3d) with a MTC at 10 渭M. Only Methia-dU (3b) was active against intra-macrophagic amastigotes with an IC₅₀ = 6.5 渭M. This latter can now be evaluated in vivo, for further investigations through structure-based drug design. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Category: thiazole).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

n-Channel Organic Semiconductors Derived from Air-Stable Four-Coordinate Boron Complexes of Substituted Thienylthiazoles was written by Hecht, Reinhard;Kade, Juliane;Schmidt, David;Nowak-Krol, Agnieszka. And the article was included in Chemistry – A European Journal in 2017.Product Details of 121359-48-6 This article mentions the following:

Three acceptor-蟺-bridge-acceptor (A-蟺-A) mols. derived from 2-(3-boryl-2-thienyl)thiazole have been synthesized and thoroughly characterized. Incorporation of a B-N unit into thienylthiazole and attachment of suitable acceptor moieties allowed to obtain ambient-stable A-蟺-A mols. with low-lying LUMO levels. Their potential for applications in organic electronics was tested in vacuum-deposited organic thin film transistors (OTFT). The OTFT device based on boryl-thienylthiazole and 1,1-dicyanomethylene-3-indanone (DCIND) acceptor moieties showed an electron mobility of 鈮?.4脳10^-2 cm² V^-1 s^-1 in air, which is the highest electron mobility reported to date for organoboron small mols. Conversely, the device employing the malononitrile (MAL) derivative as an active layer did not show any charge transport behavior. As suggested by single crystal X-ray anal. of indandione (IND) and MAL derivatives, the enhanced mobility of IND (and DCIND) in comparison to the MAL mol. can be attributed to the effective two-dimensional 蟺-stacking in the solid state imparted by the acceptor moieties with an extended 蟺-surface. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Product Details of 121359-48-6).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Product Details of 121359-48-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Electron-Deficient Polycyclic 蟺-System Fused with Multiple B鈫怤 Coordinate Bonds was written by Cao, Yirui;Zhu, Congzhi;Barlog, Maciej;Barker, Kayla P.;Ji, Xiaozhou;Kalin, Alexander J.;Al-Hashimi, Mohammed;Fang, Lei. And the article was included in Journal of Organic Chemistry in 2021.Product Details of 121359-48-6 This article mentions the following:

An extensive polycyclic 蟺-system with 23 fused rings is designed and synthesized via a highly efficient borylation reaction, in which four B-N covalent bonds and four B 鈫?N coordinate bonds are formed in one pot. B 鈫?N coordinate bonds not only lock the backbone into a near-coplanar conformation, but also decrease the LUMO energy level to around -3.82 eV, demonstrating the dual utility of this strategy for the synthesis of extensive rigid polycyclic mols. and the development of n-type conjugated materials for organic electronics and organic photovoltaics. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Product Details of 121359-48-6).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 121359-48-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

n-Channel Organic Semiconductors Derived from Air-Stable Four-Coordinate Boron Complexes of Substituted Thienylthiazoles was written by Hecht, Reinhard;Kade, Juliane;Schmidt, David;Nowak-Krol, Agnieszka. And the article was included in Chemistry – A European Journal in 2017.Product Details of 121359-48-6 This article mentions the following:

Three acceptor-π-bridge-acceptor (A-π-A) mols. derived from 2-(3-boryl-2-thienyl)thiazole have been synthesized and thoroughly characterized. Incorporation of a B-N unit into thienylthiazole and attachment of suitable acceptor moieties allowed to obtain ambient-stable A-π-A mols. with low-lying LUMO levels. Their potential for applications in organic electronics was tested in vacuum-deposited organic thin film transistors (OTFT). The OTFT device based on boryl-thienylthiazole and 1,1-dicyanomethylene-3-indanone (DCIND) acceptor moieties showed an electron mobility of ≈1.4×10^-2 cm² V^-1 s^-1 in air, which is the highest electron mobility reported to date for organoboron small mols. Conversely, the device employing the malononitrile (MAL) derivative as an active layer did not show any charge transport behavior. As suggested by single crystal X-ray anal. of indandione (IND) and MAL derivatives, the enhanced mobility of IND (and DCIND) in comparison to the MAL mol. can be attributed to the effective two-dimensional π-stacking in the solid state imparted by the acceptor moieties with an extended π-surface. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Product Details of 121359-48-6).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Product Details of 121359-48-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

3,5-bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-thiadiazin-4-one was written by Kalogirou, Andreas S.;Koutentis, Panayiotis A.. And the article was included in Molbank in 2019.Application In Synthesis of 2-(Tributylstannyl)thiazole This article mentions the following:

Stille coupling of 3,5-bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-one (10) with 2-(tri-n-butylstannyl)thiazole and Pd(Ph3P)2Cl2 in PhMe, at ca. 110°C, for 2 h, gave 3,5-bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-thiadiazin-4-one (9) in 81% yield. The latter is evaluated for its electronic properties. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Application In Synthesis of 2-(Tributylstannyl)thiazole).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application In Synthesis of 2-(Tributylstannyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis and in vitro antileishmanial activity of 5-substituted-2′-deoxyuridine derivatives was written by Peyron, Corinne;Benhida, Rachid;Bories, Christian;Loiseau, Philippe M.. And the article was included in Bioorganic Chemistry in 2005.Category: thiazole This article mentions the following:

We report herein the synthesis and the in vitro antileishmanial evaluation of 5-substituted-2′-deoxyuridine nucleosides. The most active compound against Leishmania donovani promastigotes was Thia-dU (3a) with an IC₅₀ = 3 μM. This compound exhibited the same activity as zidovudine (3′-azido-2′-deoxythymidine) used as nucleoside reference compound Considering the cytotoxicity of synthetic compounds on peritoneal murine macrophages, the most toxic compound was MeThio-dU (3d) with a MTC at 10 μM. Only Methia-dU (3b) was active against intra-macrophagic amastigotes with an IC₅₀ = 6.5 μM. This latter can now be evaluated in vivo, for further investigations through structure-based drug design. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Category: thiazole).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

n-Channel Organic Semiconductors Derived from Air-Stable Four-Coordinate Boron Complexes of Substituted Thienylthiazoles was written by Hecht, Reinhard;Kade, Juliane;Schmidt, David;Nowak-Krol, Agnieszka. And the article was included in Chemistry – A European Journal in 2017.Product Details of 121359-48-6 This article mentions the following:

Three acceptor-π-bridge-acceptor (A-π-A) mols. derived from 2-(3-boryl-2-thienyl)thiazole have been synthesized and thoroughly characterized. Incorporation of a B-N unit into thienylthiazole and attachment of suitable acceptor moieties allowed to obtain ambient-stable A-π-A mols. with low-lying LUMO levels. Their potential for applications in organic electronics was tested in vacuum-deposited organic thin film transistors (OTFT). The OTFT device based on boryl-thienylthiazole and 1,1-dicyanomethylene-3-indanone (DCIND) acceptor moieties showed an electron mobility of ≈1.4×10^-2 cm² V^-1 s^-1 in air, which is the highest electron mobility reported to date for organoboron small mols. Conversely, the device employing the malononitrile (MAL) derivative as an active layer did not show any charge transport behavior. As suggested by single crystal X-ray anal. of indandione (IND) and MAL derivatives, the enhanced mobility of IND (and DCIND) in comparison to the MAL mol. can be attributed to the effective two-dimensional π-stacking in the solid state imparted by the acceptor moieties with an extended π-surface. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Product Details of 121359-48-6).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Product Details of 121359-48-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Electron-Deficient Polycyclic π-System Fused with Multiple B←N Coordinate Bonds was written by Cao, Yirui;Zhu, Congzhi;Barlog, Maciej;Barker, Kayla P.;Ji, Xiaozhou;Kalin, Alexander J.;Al-Hashimi, Mohammed;Fang, Lei. And the article was included in Journal of Organic Chemistry in 2021.Product Details of 121359-48-6 This article mentions the following:

An extensive polycyclic π-system with 23 fused rings is designed and synthesized via a highly efficient borylation reaction, in which four B-N covalent bonds and four B ← N coordinate bonds are formed in one pot. B ← N coordinate bonds not only lock the backbone into a near-coplanar conformation, but also decrease the LUMO energy level to around -3.82 eV, demonstrating the dual utility of this strategy for the synthesis of extensive rigid polycyclic mols. and the development of n-type conjugated materials for organic electronics and organic photovoltaics. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Product Details of 121359-48-6).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 121359-48-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica