Fatostatin suppresses growth and enhances apoptosis by blocking SREBP-regulated metabolic pathways in endometrial carcinoma was written by Gao, Shuhong;Shi, Zhengzheng;Li, Xin;Li, Wenzhi;Wang, Yiling;Liu, Zhiming;Jiang, Jie. And the article was included in Oncology Reports in 2018.Formula: C18H19BrN2S This article mentions the following:
Fatostatin, a chem. inhibitor of the sterol regu- latory element-binding protein (SREBP) pathway, has been reported to possess high antitumor activity against prostate and pancreatic cancer. The main aim of the present study was to investigate the effects and mechanism of fatostatin in endo- metrial carcinoma (EC). In the present study, we determined that fatostatin inhibited EC cell viability and colony formation capacity, decreased the invasive and migratory capacities of EC cells, induced EC cell cycle arrest at the G2/M phase and stimulated caspase-mediated apoptosis of EC cells. In addition, fatostatin significantly decreased the protein expression levels of nuclear SREBPs and their downstream genes and increased the protein expression levels of cleaved caspase-9, caspase-3 and PARP in EC cells. In addition, the mRNA expression levels of SREBP-controlled downstream genes were also significantly downregulated. The quantification assays of fatty acids and total cholesterol revealed that the levels of free fatty acids and total cholesterol in EC cells were decreased. The present study indicated that fatostatin exhibited antitumor effects by blocking SREBP-regulated metabolic pathways and inducing caspase-mediated apoptosis in EC and may be a potent therapeutic strategy for the treatment of EC. In the experiment, the researchers used many compounds, for example, 2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide (cas: 298197-04-3Formula: C18H19BrN2S).
2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide (cas: 298197-04-3) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Formula: C18H19BrN2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica