41731-52-6, As the paragraph descriping shows that 41731-52-6 is playing an increasingly important role.
41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 3-tert-butyl phenol (100 mg, 0.65 mmol) in dry THF (5 ml) was added potassium tert-butoxide (75 mg, 0.65 mmol) and the mixture was heated to reflux for 1 h. Upon cooling, the volatiles were removed in vacuo before the residue was taken up into dimethylsulf oxide (DMSO; 20 ml). Ethyl 2-chiorothiazole-4-carboxylate (prepared according to the procedure of T. R. Kelly and F. Lang, J. Org. Chem., 1996, 61 , 4623-4633; however in our EPO hands the material produced by this synthesis was a 2:1 mixture of the 2- chloro- and 5-chloro-thiazole-4-carboxylates; 130 mg, 0.67 mmol) was then added before the mixture was heated to 85 G for 16 h. Upon cooling the reaction mixture was partitioned between ethyl acetate (25 ml) and water (25 ml) and after rigorous shaking the aqueous later was separated and extracted further with ethyl acetate (3 x 25 ml). The combined organic phase was washed with brine (50 ml) and dried (MgSO4) before being concentrated in vacuo. The crude product was then purified by column chromatography (SiO2; 49:1 light petroleum-ethyl acetate to 19:1) to afford the title compound as a pale yellow oil (100 mg, 50 %). 1H NMR delta 8.20 (1 H, s), 7.20-7.27 (3 H, m), 7.01-7.05 (1 H, m), 4.31 (2 H, q), 1.31 (3 H, t) and 1.26 (9 H, s).
41731-52-6, As the paragraph descriping shows that 41731-52-6 is playing an increasingly important role.
Reference£º
Patent; PARADIGM THERAPEUTICS LTD.; WO2007/582; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica