Tag: 41731-83-3

41731-83-3, Ethyl 2-bromothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 5; (R)-2-(2-(1-(4-(1-hydroxyhexyl)phenyl)-5-oxopyrrolidin-2-yl)ethylthio)thiazole-5-carboxylic acid (22); Step 1. Conversion of 10 to 20Ethyl 2-bromothiazole-5-carboxylate (15 muL, 0.10 mmol), tributylphosphine (5 muL, 0.02 mmol), and potassium carbonate (20 mg, 0.15 mmol), were added sequentially to a solution of thioacetate 10 (crude from example 1, step 8, 45 mg, 0.094 mmol) in absolute EtOH (0.38 mL). After stirring overnight at room temperature, the volatiles were removed under a stream of nitrogen. The resulting residue was suspended in EtOAc and then decanted and concentrated in vacuo. The crude residue was purified on 4 g silica (hexanes?EtOAc, gradient) to afford 55 mg (99%) of 20.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Allergan, Inc.; US2008/269498; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To a mixture of ethyl 2-bromo-1 ,3-thiazole-5-carboxylate (1.01 g, 4.29 mmol), K2CO3 (2.0 g, 14.47 mmol) and Pd(Pt-Bu3)2 (280 mg, 0.548 mmol) in 1 ,4-dioxane (8 ml.) and water (1.6 ml.) was added 1 -methyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)- 1 H-pyrazole (1.76 g, 8.47 mmol) [prepared in Preparation 2]. The reaction was stirred at 120 0C for 45 min in a microwave reactor and cooled to room temperature. The mixture was partitioned between CHCI3 / H2O and the aqueous layer was washed several times with CHCI3. The combined organic fractions were dried over Na2SO4, concentrated, and purified via column chromatography (silica, 0-50%EtOAc/hexanes) affording the title compound (0.7 g, 61%) as a yellow solid: LC-MS (ES) m/z = 238 (M+H)+.

41731-83-3 Ethyl 2-bromothiazole-5-carboxylate 3614103, athiazole compound, is more and more widely used in various.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/158372; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of compound IE (2.2 g, 10.0 mmol), N-methylpiperazine (1.1 g, 11.0 mmol), and K2C03 (3.4 g, 24.9 mmol) in acetonitrile (70 mL) was stirred at 80 C for 24 h. The mixture was concentrated and diluted with H20 and extracted with EtOAc (3x). The combined organic layers were dried and then concentrated to give compound 1G (2.5 g, >100%) as a brown solid. 1H NMR (400 MHz, CDC13) delta 7.85 (s, 1H), 4.28 (q, J = 1.2 Hz, 2H), 3.58 (t, J = 5.6 Hz, 4H), 2.50 (t, J = 5.6 Hz, 4H), 2.33 (s, 3H), 1.32 (t, J = 1.2 Hz, 3H).

41731-83-3 Ethyl 2-bromothiazole-5-carboxylate 3614103, athiazole compound, is more and more widely used in various.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; STOCKING, Emily, M.; WRASIDLO, Wolfgang; WO2015/116663; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica