Tag: 45865-42-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.45865-42-7,5-(tert-Butyl)-4-methylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 5-tert-butyl-4-methylthiazole-2-ylamine (1.5 g, 8.8 mmol) and 2-bromoethyl methyl ether (0.91 mL, 9.7 mmol) was warmed to 85 0C and allowed to stir for 24 hours. The crude material was dissolved in ~5 mL of a 1 :1 mixture OfCH2Cl2 and CH3OH and a small amount of silica gel was added. This mixture was concentrated to dryness and the residue was purified via flash column chromatography (SiO2, 9:1 :0.1 CH2Cl2 :CH3OH:NH4OH) to afford the title compound (1.0 g, 4.4 mmol, 50% yield). 1H NMR (300 MHz, CD3OD) delta ppm 1.41 (s, 9 H) 2.38 (s, 3 H) 3.35 (s, 3 H) 3.66 (t, J=4.70 Hz, 2 H) 4.16 (t, J=4.70 Hz, 2 H); MS (DCI/NH3) m/z 229 (M+H)+

45865-42-7 5-(tert-Butyl)-4-methylthiazol-2-amine 1081536, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/67613; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

45865-42-7, 5-(tert-Butyl)-4-methylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the solution of 5-tert-Butyl-4-methyl-thiazol-2-ylamine (1.12 g, 6.6 mmol) in dryDMF (20 mL) was added triethylamine (0.92 mL, 1 eq). 2,2,2-trichloroethyl chloroformate (0.9 mL, 6.6 mmol) was added in a dropwise manner at room temperature. The reaction mixture was stirred at room temperature for 3 hrs. Dry DMF (40 mL) was added, washed with brine (320 mL), water (220 mL), dried, filtered, concentrated to afford compound 4, (5-tert-butyl-4-methyl-thiazol-2-yl)-carbamic acid 2,2,2-trichloro-ethyl ester (1.40 g, 4.0 mmol, 61%) as a white solid.MS: 347.0 (M+1)1HNMR (DMSO-d6) ppm: 1.26 (9H, s), 2.12 (3H, s), 4.90 (2H, s)

The synthetic route of 45865-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Du, Xiaomin; Hao, Yan; Zhang, Lanying; US2010/298385; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica