Tag: 556-90-1

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

556-90-1, To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.1 5-(3,4-Dimethoxybenzylidene)-2-iminothiazolidin-4-one (14a) Yellow solid; mp > 200 C; 235 mg, 45% yield; IR (neat) numax = 3344, 2759, 1720, 1690, 1678 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta = 9.35 (s, 1H), 9.09 (s, 1H), 7.54 (s, 1H), 7.08-7.16 (m, 3H), 3.80 (s, 6H); 13C NMR (100 MHz, CD3SOCD3): delta = 180.52, 175.39, 149.98, 148.81, 129.42, 126.62, 126.51, 122.77, 112.63, 111.98, 55.57, 55.38; HRMS (ESI-TOF): m/z calculated for C12H12N2O3S [M+Na]+, 287.0466; found 287.0461.

The synthetic route of 556-90-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.,556-90-1

General procedure: Synthesis of Compounds 120 to 122, which are (Z)-5-(substituted benzylidene)-2-iminothiazolidin-4-one analogs, was performed as follows. In detail, in an acetic acid (4 mL/1 g sodium acetate) solvent, a mixture including a substituted benzaldhehyde (300 mg), pseudothiohydantoin (1.1 eq.), and sodium acetate (3.0 eq.) was refluxed for 3 to 7 hours. After cooling, water was added thereto, and the produced precipitate was filtered, and in consideration of physical characteristics of the used starting materials, the resultant precipitate was washed with water and methylene chloride and/or ethyl acetate to obtain a solid target product.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Pusan National University Industry University Cooperation Foundation; Jung, Hae Young; Moon, Hyung Ryong; Park, Min Hwe; Ha, Young Mi; Park, Yoon Jung; Park, Ji Young; Kim, Jin-a; Lee, Ji Yeon; Lee, Kyung Jin; (57 pag.)KR101677122; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of dimethyl acetylenedicarboxylate (0.14 g, 1 mmol) and 2-imino-1,3-thiazolidin-4-one (3) (0.118 g, 1 mmol) in anhydrous CH2Cl2 (5 mL) was added dropwise a solution of cyclohexyl isocyanide (0.083 g, 1 mmol) in anhydrous CH2Cl2 (3 mL) at rt over 10 min. The reaction mixture was then stirred for 24 h. The solvent was removed under reduced pressure and the residue purified by silica gel (Merck 230-240 mesh) column chromatography using hexane-EtOAc as eluent to yield 4a.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.

Reference£º
Article; Esmaeili, Abbas Ali; Zangouei, Mahdieh; Fakhari, Ali Reza; Habibi, Azizollah; Tetrahedron Letters; vol. 53; 11; (2012); p. 1351 – 1353;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: The desired compounds, (Z)-5-(substituted benzylidene)-2-iminothiazolidin-4-one analogues (1a- 1l) (Figure 1), were prepared by Knoevenagel condensation.With one exception, refluxing a solution of appropriate benzaldehydes and pseudothiohydantoinin acetic acid in the presence of NaOAc produced (Z)-5-benzylidene-2-iminothiazolidin-4-ones as a single stereoisomer in yields of 41.4-94.1%. A Knoevenagel condensation between 2,4-dimethoxy benzaldehyde and pseudothiohydantoin under the same conditions gave amixture of (E)- and (Z)-5-(2,4-dimethoxybenzylidene)-2-iminothiazolidin-4-ones. These compounds could not be easily separated by conventional silica gel column chromatography. Milder reaction conditions capable of accomplishing the Knoevenagel condensation were needed to synthesize only (Z)-stereoisomer. Interestingly,heating a solution of 2,4-dimethoxy benzaldehyde and pseudothiohydantoin in ethanol:H2O (1:1) in the presence of 1.0 equiv. of piperidine as a base catalyst at 80 C afforded the corresponding (Z)-stereoisomer(1l) as a sole product. A suspension of an appropriate benzaldehyde (300 mg, 1.53-2.46 mmol), pseudothiohydantoin(1.1 eq.), and sodium acetate (3.0 eq.) in acetic acid (1 mL/1 mmol of benzaldehyde) was refluxed for 3-7 h. The reaction mixture was cooled and water was added. The resulting precipitates were filtered, and washed with water and, if necessary, a small amountof methylene chloride or ethyl acetate, to produce (Z)-5-(substituted benzylidene)-2-iminothiazolidin-4-oneproducts (1a – 1k) in 41.4-94.1% yields. The resulting precipitates were filtered, and washed with water,ethyl acetate and methylene chloride to give (Z)-5-(2,4-dimethoxybenzylidene)-2-iminothiazolidin-4-one (1l) all final products were confirmed by 1H and 13C NMR spectroscopy and mass spectroscopy.

As the paragraph descriping shows that 556-90-1 is playing an increasingly important role.

Reference£º
Article; Jung, Hee Jin; Lee, Min Jung; Park, Yeo Jin; Noh, Sang Gyun; Kyoung; Moon, Kyoung Mi; Lee, Eun Kyeong; Bang, Eun Jin; Park, Yun Jung; Kim, Su Jeong; Yang, Jungho; Ullah, Sultan; Chun, Pusoon; Jung, Young Suk; Moon, Hyung Ryong; Chung, Hae Young; Bioscience, Biotechnology and Biochemistry; vol. 82; 5; (2018); p. 759 – 767;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica