Tag: 55661-33-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.,55661-33-1

Preparation of 3,5-di-tert-butyl-4-hydroxy-N-(1-(thiazol-2-ylmethylcarbamoyl)cyclopropyl)-benzamide; 1-(3,5-Di-tert-butyl-4-hydroxybenzamido)cyclopropanecarboxylic acid (100 mg, 0.3 mmol), thiazol-2-ylmethanamine (50 mg, 0.45 mmol), HATU (171 mg, 0.45 mmol) and DIPEA (0.15 mL, 0.9 mmol) were stirred in DCM at rt for 16 h. The organics were washed sequentially with saturated NaHCO3, 0.1 M HCl, dried (Na2SO4), concentrated in-vacuo and the residue purified by Biotage (5% MeOH/DCM) to give 3,5-di-tert-butyl-4-hydroxy-N-(1-(thiazol-2-ylmethylcarbamoyl)cyclopropyl)-benzamide (57 mg, 45.0%). MS: m/z=430.2 (calc’d for C23H31N3O3S 429.2).

As the paragraph descriping shows that 55661-33-1 is playing an increasingly important role.

Reference£º
Patent; Galemmo, JR., Robert; Holland, Richard; Hum, Gabriel; Pajouhesh, Hossein; Chahal, Navjot; Seid-Bagherzadeh, Mehran; Girard, Amy; US2009/270394; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

General procedure: 5.1.5 2-(1-(4-Fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide (7a) To a solution of 6a (2.00 g, 5.98 mmol), EDCI (1.50 g, 7.82 mmol) and iPr2NEt (2.67 mL, 15.64 mmol) in N,N-dimethylformamide (80 mL) was added HOBt (1.00 g, 7.40 mmol). The reaction mixture was stirred at ambient temperature for 15 min, followed by addition of 3-(aminomethyl)pyridine (0.73 mL, 7.16 mmol). After stirring for 17 h at ambient temperature, the reaction mixture was diluted with ethyl acetate (300 mL) and sequentially washed with water, saturated NaHCO3 solution, water and brine. The organic solution was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo, and the residue was crystallized from ethyl acetate and hexanes to yield 7a as an off-white solid (1.93 g, 76%), mp 178-180 C (ethyl acetate/hexanes); By a similar procedure as described for 7a, 7h was obtained as an off-white solid (0.17g, 66%). Mp 189-190C (ethyl acetate/hexanes); 1H NMR (300MHz, CDCl3) delta 8.25 (s, 1H), 7.74 (br s, 1H), 7.40-7.31 (m, 3H), 7.06-6.97 (m, 2H), 6.78 (t, J=5.4Hz, 1H), 4.97 (s, 2H), 4.92 (d, J=5.4Hz, 2H), 2.67 (s, 3H); MS (ES+) m/z 431.1 (M+1), 55661-33-1

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Article; Sun, Shaoyi; Zhang, Zaihui; Pokrovskaia, Natalia; Chowdhury, Sultan; Jia, Qi; Chang, Elaine; Khakh, Kuldip; Kwan, Rainbow; McLaren, David G.; Radomski, Chris C.; Ratkay, Leslie G.; Fu, Jianmin; Dales, Natalie A.; Winther, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 455 – 465;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

55661-33-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

Example 3; 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)-7V-(l,3-thiazol-2-ylmethyl)acetamide; N1-((ethylimino)methylene)-Lambda/3,Lambda/3-dimethylpropane-l ,3-diamine hydrochloride(0.049 g, 0.254 mmol) , 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)acetic acid (Example 1C, 0.050 g, 0.169 mmol) and thiazol-2-ylmethanamine (0.021 g, 0.186 mmol) were combined and stirred together in dichloromethane (0.5 mL) at room temperature. After stirring overnight, the reaction was loaded directly onto a SF 15- 12 silica gel column (Analogix, Burlington, WI), and the title compound was eluted using a gradient of 5% to 100% ethyl acetate/hexanes over 20 minutes (flow = 30 mL/minute). 1H NMR (300 MHz, CDCl3) delta ppm 7.69 (d, J= 3.3 Hz, 1 H), 7.19-7.38 (m, 11 H), 6.77 (t, J= 5.8 Hz, 1 H), 4.67 (d, J= 5.8 Hz, 2 H), 4.09 (s, 2 H), 3.53 (t, J= 6.5 Hz, 2 H), 2.84 (t, J= 6.5 Hz, 2H); MS (ESI+) m/z 392 (M+H)+.

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; BHATIA, Pramila, A.; DOHERTY, George, A.; DRIZIN, Irene; MACK, Helmut; PERNER, Richard, J.; STEWART, Andrew, O.; ZHANG, Qing Wei; WO2010/39947; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica