56354-98-4归档 - Heterocyclic Building Blocks-Thiazole

Analyzing the synthesis route of 56354-98-4

56354-98-4 6-Aminobenzo[d]thiazol-2(3H)-one 6453329, athiazole compound, is more and more widely used in various.

56354-98-4, 6-Aminobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Asolution of 2,6-difluoro-3nitropyridine (0.20g. 1.3 mrnol) and &aminobenzo[d]thiazol.-2(3H)-one (0.20 g, 1.2 mmol) in DMF (6 mL) was heated at 100 C for 1 h. Benzaldehyde (0.15 g, 1.4 mmol) was added to the mixture and the reaction was let stir for 30 mm followed by addition of sodium dithionite (0.65g. 3.8 mmoi). After 12 hat 100 C the reaction was cooled, diluted with EtOAc (50mL), and washed with H20 (25 mL x 3). The organic layer was dried (Na2504) and concentrated in vaeuo. Purification FCC. Si02, EtOAc/hexanes) afforded the title compound (0.10 g, 22%). MS (ESfl: mass caicd. for C,9H, ,FN4OS, 362.1; miz found, 363.1 [M+Hf. ?H NMR (400 MHz, DMSO-d6) oe 12.19 (br s, 11-I), 8.39 (dd, ,j:::: 8.5, 7.2 Hz. ifI). 7.79 (d, J::: 2.1 Hz, IH), 7.60 7.53 (m, 21-I), 7.48 — 7.37 (m. 31:1), 7.31 (dd, J: 8.4. 2.1 Fiz, 11-I), 7.24 (d, ,j:::: 8.4 Hz, IH), 7,14 (dd, J::::8.5.0.8Hz, 11-I).

56354-98-4 6-Aminobenzo[d]thiazol-2(3H)-one 6453329, athiazole compound, is more and more widely used in various.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BERRY, Cynthia G.B.; CHEN, Gang; JOURDAN, Fabrice Loic; LEBOLD, Terry Patrick; LIN, David Wei; PENA PINON, Miguel Angel; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; WU, Dongpei; ZHANG, Wei; AMERIKS, Michael K.; (407 pag.)WO2016/176460; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 56354-98-4

56354-98-4 6-Aminobenzo[d]thiazol-2(3H)-one 6453329, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56354-98-4,6-Aminobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: A mixture comprising 60.0 mg (307 mumol) 4-chloro-6-ethyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidine (prepared according to intermediate exampLe 1a), 51 mg 6-amino-1,3-benzothiazol-2(3H)-one (CAS-No: 56354-98-4), 1.75 mL ethanol and 16.9 muL hydrochloric acid (4M in dioxane) was reacted at 110C for 10 hours. The residue was digested in a mixture of diethyl ether and ethanol and dried to give 85.3 mg (85%) of the title compound.

56354-98-4 6-Aminobenzo[d]thiazol-2(3H)-one 6453329, athiazole compound, is more and more widely used in various.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; WORTMANN, Lars; KETTSCHAU, Georg; PUeHLER, Florian; LIENAU, Philip; PETERSEN, Kirstin; HAeGEBARTH, Andrea; SUeLZLE, Detlev; WO2014/44691; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Simple exploration of 56354-98-4

As the paragraph descriping shows that 56354-98-4 is playing an increasingly important role.

A mixture comprising 60.0 mg (307 mumol) 4-chloro-6-ethyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidine (prepared according to intermediate exampLe 1a), 51 mg 6-amino-1,3-benzothiazol-2(3H)-one (CAS-No: 56354-98-4), 1.75 mL ethanol and 16.9 muL hydrochloric acid (4M in dioxane) was reacted at 110C for 10 hours. The residue was digested in a mixture of diethyl ether and ethanol and dried to give 85.3 mg (85%) of the title compound. 1HNMR (DMSO-d6): delta = 1.16 (3H), 2.37 (3H), 2.66 (2H), 7.23 (1H), 7.37 (1H), 7.74 (1H), 8.10 (1H), 9.65 (1H), 12.18 (1H), 12.50 (1H) ppm.

As the paragraph descriping shows that 56354-98-4 is playing an increasingly important role.