Tag: 598.55

Reconstitution time and microbial contamination during reconstitution of antibiotic kit product was written by Ishii, Masahide. And the article was included in Igaku to Yakugaku in 1995.Reference of 66309-69-1 This article mentions the following:

Reconstitution time determination indicated that antibiotic (pansporin) kit preparation is superior to antibiotic half kit preparation or conventional injection. Microbial contamination tests showed similar results (neg.) for all the 3 products (methods) tested. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Reference of 66309-69-1).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Reference of 66309-69-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Incompatibility of cefotiam dihydrochloride in parenteral preparations by high-performance liquid chromatography was written by Tanno, Keiki;Ikarashi, Kuniichi;Sasahara, Kazuhisa;Kato, Masami. And the article was included in Japanese Journal of Antibiotics in 1982.Synthetic Route of C18H25Cl2N9O4S3 This article mentions the following:

Changes in external appearance, pH, and residual antimicrobial potency of cefotiam-HCl (I) [66309-69-1] were examined in combination with infusion solutions and other injections. The combination of I with bromhexine-HCl聽聽[611-75-6], dipyridamole聽聽[58-32-2], and gabexate聽mesilate聽聽[56974-61-9] was incompatible because of the turbidity produced. No change was observed in 34 other combinations. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Synthetic Route of C18H25Cl2N9O4S3).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Synthetic Route of C18H25Cl2N9O4S3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Stability study on cefotiam hydrochloride and xylitol injection formulation was written by Hu, Zhong-jie;Zhou, Lei;Miao, Pei-hong. And the article was included in Xibei Yaoxue Zazhi in 2007.Application of 66309-69-1 This article mentions the following:

This paper aims to study the stability of cefotiam hydrochloride and xylitol injection formulation. Cefotiam hydrochloride and xylitol injection formulation was placed at room temperature (25掳) for 8 h, and during this period its content change was determined by UV spectrophotometry. Its appearance, pH and particle changes were observed at the same time. It was found that cefotiam hydrochloride and xylitol injection formulation kept stable within 6 h. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Application of 66309-69-1).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 66309-69-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Comparative examination of compatibility of potassium canrenoate (Soldactone) at the clinical usage was written by Ozawa, Kazuo;Abe, Seiji;Nemoto, Akiko;Ito, Yoko;Satoh, Kazue;Yamamoto, Toshinori;Murayama, Jun-Ichiro. And the article was included in Iryo Yakugaku in 2002.Recommanded Product: (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride This article mentions the following:

The authors examined the compatibility of a commercialized potassium canrenoate preparation (Soldactone) with 124 other kinds of currently prescribed injectable preparations as counter substances based upon the physicochem. parameters. The appearance, pH, and the concentration of canrenoate were used as markers after mixing for 24 h with other injectable preparations, since appearances can be deceptive. In order to estimate the remaining content of canrenoate after mixing, the concentrations of canrenoate were determined by UV absorption at the wavelength of 293 nm, using a spectrophotometer and reversed phase high-performance liquid chromatog. (HPLC). As the results, no change was detected in 53 of the 124 counter preparations in the mixture and the content of canrenoate was above 90%. Sixteen total parenteral nutrition solutions, 5 amino acid solutions and 17 antibiotics dissolved in saline were incompatible with canrenoate. We also examined the compatibility of canrenoate, which was directly added to furosemide (20 mg and 100 mg) and 5% of glucose preparations In the case of a furosemide injection (20mg), the appearance, pH and turbidity did not change, while the concentration of canrenoate decreased to less than 90% of the control. On the other hand, a glucose preparation (5%) did not show any incompatibility with the counter preparations Therefore, the canrenoate preparations can be dissolved into 5% glucose solution, prior to the clin. application. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Recommanded Product: (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Recommanded Product: (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reconstitution time and microbial contamination during reconstitution of antibiotic kit product was written by Ishii, Masahide. And the article was included in Igaku to Yakugaku in 1995.Reference of 66309-69-1 This article mentions the following:

Reconstitution time determination indicated that antibiotic (pansporin) kit preparation is superior to antibiotic half kit preparation or conventional injection. Microbial contamination tests showed similar results (neg.) for all the 3 products (methods) tested. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Reference of 66309-69-1).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Reference of 66309-69-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Incompatibility of cefotiam dihydrochloride in parenteral preparations by high-performance liquid chromatography was written by Tanno, Keiki;Ikarashi, Kuniichi;Sasahara, Kazuhisa;Kato, Masami. And the article was included in Japanese Journal of Antibiotics in 1982.Synthetic Route of C18H25Cl2N9O4S3 This article mentions the following:

Changes in external appearance, pH, and residual antimicrobial potency of cefotiam-HCl (I) [66309-69-1] were examined in combination with infusion solutions and other injections. The combination of I with bromhexine-HCl  [611-75-6], dipyridamole  [58-32-2], and gabexate mesilate  [56974-61-9] was incompatible because of the turbidity produced. No change was observed in 34 other combinations. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Synthetic Route of C18H25Cl2N9O4S3).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Synthetic Route of C18H25Cl2N9O4S3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Stability study on cefotiam hydrochloride and xylitol injection formulation was written by Hu, Zhong-jie;Zhou, Lei;Miao, Pei-hong. And the article was included in Xibei Yaoxue Zazhi in 2007.Application of 66309-69-1 This article mentions the following:

This paper aims to study the stability of cefotiam hydrochloride and xylitol injection formulation. Cefotiam hydrochloride and xylitol injection formulation was placed at room temperature (25°) for 8 h, and during this period its content change was determined by UV spectrophotometry. Its appearance, pH and particle changes were observed at the same time. It was found that cefotiam hydrochloride and xylitol injection formulation kept stable within 6 h. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Application of 66309-69-1).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 66309-69-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Comparative examination of compatibility of potassium canrenoate (Soldactone) at the clinical usage was written by Ozawa, Kazuo;Abe, Seiji;Nemoto, Akiko;Ito, Yoko;Satoh, Kazue;Yamamoto, Toshinori;Murayama, Jun-Ichiro. And the article was included in Iryo Yakugaku in 2002.Recommanded Product: (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride This article mentions the following:

The authors examined the compatibility of a commercialized potassium canrenoate preparation (Soldactone) with 124 other kinds of currently prescribed injectable preparations as counter substances based upon the physicochem. parameters. The appearance, pH, and the concentration of canrenoate were used as markers after mixing for 24 h with other injectable preparations, since appearances can be deceptive. In order to estimate the remaining content of canrenoate after mixing, the concentrations of canrenoate were determined by UV absorption at the wavelength of 293 nm, using a spectrophotometer and reversed phase high-performance liquid chromatog. (HPLC). As the results, no change was detected in 53 of the 124 counter preparations in the mixture and the content of canrenoate was above 90%. Sixteen total parenteral nutrition solutions, 5 amino acid solutions and 17 antibiotics dissolved in saline were incompatible with canrenoate. We also examined the compatibility of canrenoate, which was directly added to furosemide (20 mg and 100 mg) and 5% of glucose preparations In the case of a furosemide injection (20mg), the appearance, pH and turbidity did not change, while the concentration of canrenoate decreased to less than 90% of the control. On the other hand, a glucose preparation (5%) did not show any incompatibility with the counter preparations Therefore, the canrenoate preparations can be dissolved into 5% glucose solution, prior to the clin. application. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Recommanded Product: (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Recommanded Product: (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica