With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: The suspension of acid (2.00 mmol) in DMF (10 mL) was cooled to 0 C in an ice bath. N-methylmorpholine (0.49 mL, 4.40 mmol) and TBTU (0.84 g, 2.60 mmol) were added, and the reaction mixture was stirred at 0 C for 0.5 h. Then it was allowed to reach room temperature, and amine (2.00 mmol) was added to the solution.The reaction mixture was stirred overnight at room temperature, after which the solvent was evaporated under reduced pressure.The residue was dissolved in ethyl acetate (40 mL) and washed witha saturated aqueous solution of NaHCO3 (3 x 20 mL), 10% citric acid(3 x 20 mL) and brine (20 mL). The organic phase was dried over Na2SO4, and filtered, and the solvent was removed under reduced pressure. The crude product was purified by crystallization or flash column chromatography., 67899-00-7
67899-00-7 2-Amino-4-methylthiazole-5-carboxylic acid 832243, athiazole compound, is more and more widely used in various.
Reference£º
Article; ?kedelj, Veronika; Perdih, Andrej; Brvar, Matja?; Krofli?, Ana; Dubbee, Vincent; Savage, Victoria; O’Neill, Alex J.; Solmajer, Tom; Be?ter-Roga?, Marija; Blanot, Didier; Hugonnet, Jean-Emmanuel; Magnet, Sophie; Arthur, Michel; Mainardi, Jean-Luc; Stojan, Jure; Zega, Anamarija; European Journal of Medicinal Chemistry; vol. 67; (2013); p. 208 – 220;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica