With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.682342-65-0,5-Iodo-4-(trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.,682342-65-0
2-Amino-5-iodo-4-trifluoromethylthiazole (1.2 g) was dissolved in pyridine (2 ml) and thiophene-2-carbonyl chloride (0.80 g) was added at room temperature with stirring. The mixture was stirred for 6 hr at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The chloroform layer was dried over magnesium sulfate and the solvent was removed under reduced pressure. The solid thus obtained was recrystallized from methanol to give N-(5-iodo-4-trifluoromethylthiazol-2-yl)thiophene-2-carboxamide (1.2 g), m. p. 184-185 C.
682342-65-0 5-Iodo-4-(trifluoromethyl)thiazol-2-amine 22717671, athiazole compound, is more and more widely used in various.
Reference£º
Patent; Nippon Soda Co., Ltd.; US2004/82629; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica