687636-93-7, 2-Bromothiazole-5-methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of N-(5-{[(2-chlorophenyl)oxy]methyl}-1 ,3,4-thiadiazol-2-yl)-1 ,2,3,4- tetrahydro-6-isoquinolinecarboxamide (Example 1 ) (218 mg, 0.5 mmol), DBU (0.224 ml_, 1.5 mmol) and (2-bromo-1 ,3-thiazol-5-yl)methanol (97 mg, 0.5 mmol) in THF (10 ml.) was stirred overnight at 8O0C. Then extra amounts of DBU (0.075 ml_, 0.5 mmol) and (2-bromo-1 ,3-thiazol-5-yl)methanol (97 mg, 0.5 mmol) were added and the mixture was stirred overnight at 600C. The THF was evaporated under reduced pressure and the residue was dissolved in DCM. The organic phase was washed with water then dried over sodium sulphate. After filtration and evaporation under reduced pressure, the residue was purified by flash column chromatography eluting with a gradient DCIWMeOH: 99/1 to DCM/MeOH: 95/5 to give after trituration in cold DCM and drying the title compound as white solid (15 mg, 6%).HRMS calculated for C23H20CIN5O3S2 (M+H)+ 514.0775, found: 514.0770, Rt: 2.70 min MP: 237-239C, 687636-93-7
687636-93-7 2-Bromothiazole-5-methanol 7213124, athiazole compound, is more and more widely used in various.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/104524; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica