With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7210-73-3,Ethyl 4-methylthiazole-2-carboxylate,as a common compound, the synthetic route is as follows.,7210-73-3
A solution of ethyl 4-methyl-1 ,3-thiazole-2-carboxylate (1120) (208 mg, 1.215 mmol) in ethanol (6.028 ml) was stirred at room temperature under an atmosphere of argon. Hydrazine (0.046 ml, 1.458 mmol) was added and the solution was heated to reflux for 18 hours. The solution was cooled to room temperature and then the solvent was removed under reduced pressure to give a pale yellow coloured solid of desired product in 115 mg. LCMS m/z 157.92 [M+H] (at) 0.41 min (2 min run).
The synthetic route of 7210-73-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica