With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7709-58-2,4-(Chloromethyl)thiazole hydrochloride,as a common compound, the synthetic route is as follows.,7709-58-2
Reference Example 5 6,7,8-Trifluoro-1-(4-thiazolylmethyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 1.5 g of ethyl 6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylate was dissolved in 30 ml of DMF, and 0.43 g of 60% oily sodium hydride was added, followed by stirring at 80 C. in a nitrogen gas stream for 20 minutes. To this solution, 1.9 g of 4-chloromethylthiazole hydrochloride was added, followed by stirring at constant temperature for 15 hours, after which the reaction mixture was concentrated to dryness. The residue was dissolved in CHCl3; the organic layer was washed with water and dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate=1:2) to yield 0.46 g of ethyl 6,7,8-trifluoro-1-(4-thiazolylmethyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate as a colorless powder.
The synthetic route of 7709-58-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5519024; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica