Tag: 88982-82-5

88982-82-5, 4-Bromo-1,3-thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,88982-82-5

Intermediate 14 (1.98g, 9.5 mmol) was dissolved in methanol (50 ml) and N-(3- dimethylaminopropyl)-iV-ethylcarbodiimide hydrochloride (2.73g, 14.3mmol), 1- hydroxybenzotriazole (1.93g, 14.3mmol), and diisopropylethylamine (2.5ml, 14.3mmol) added. The resulting mixture was stirred at room temperature for 17 hours. The mixture was evaporated, and the resulting residue partitioned between CH2Cl2 and water. The organic layer was washed30 with IN HCl, sat. NaHCO3, sat. NaCl, dried over Na2SO4, filtered and evaporated to give the title compound. 1HNMR (500 MHz, CDCl3) delta: 7.57 (s, IH), 4.04 (s, 3H).

88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various.

Reference£º
Patent; MERCK & CO., INC.; WO2008/57336; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

88982-82-5, 4-Bromo-1,3-thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-bromothiazole-2-carboxylic acid 11 (25.0 mg, 0.12 mmol) in DCM (2.0 mL), oxalyl chloride (0.02 mL,0.23 mmol) was added dropwise, and then DMF (2 drops) was added. The mixture was stirred at room temperature for 2 h and concentrated, dried by vacuum. DCM(3.0 mL) was added to the mixture and the mixture was cooled to 0 C and 3-aminobenzonitrile (60.0 mg, 0.51 mmol), DIEA (0.03 mL,0.17 mmol) was added. The mixture was stirred at room temperature overnight. The subsequent mixture was concentrated under reduced pressure and extractedwith H2O/ethyl acetate. The combined organic layer was dried by Na2SO4,concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 5:1) to afford the title compound 6be (16.0 mg, 43 %) as white solid: 1H-NMR (400MHz, CDCl3) delta 9.05(s, 1H), 8.16 (d, J = 1.64 Hz, 1H),7.86 (dt, J = 7.60, 1.92 Hz, 1H),7.59 (s, 1H), 7.48 (m, 2H). 13C-NMR (100 MHz, CDCl3) delta 163.2, 156.2, 137.6, 130.2, 128.5, 126.0,124.4, 123.9, 123.0, 118.2, 113.5. LC/MS (ESI-) 305.9 (M-H)+.

88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various.

Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 4-bromothiazole-2-carboxylic acid (40.0 mg, 0.19 mmol) in DMF (3.0mL), HBTU (86 mg, 0.23 mmol) was added dropwise, and then DMF (2 drops) was added. The mixture was stirred at room temp for 2 h, concentrated under reduced pressure and dried by vacuum. DCM (3.0 mL) was added to the residue and the resulting solution was cooled to 0 C and 2-aminopyridine (20.0 mg, 0.20 mmol),TEA (0.2 mL, 1.43 mmol) was added. The mixture was stirred at room temperature 3 h. The subsequent mixture was concentrated under reduced pressure andextracted with H2O/ethyl acetate. The combined organic layer wasdried by Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 5:1) toafford the title compound 6be (25.0 mg, 46 %) as white solid; 1H-NMR(400 MHz, CDCl3) delta 9.56(s, 1H), 8.36 (dq, J = 4.8, 0.8 Hz,1H), 8.27 (d, J = 8.4 Hz , 1H), 7.76(t, J = 7.6 Hz, 1H), 7.54 (s, 1H),7.11 (ddd, J = 7.2, 4.8, 0.8 Hz, 1H).13C-NMR (100 MHz, CDCl3) delta 163.3, 156.4, 150.3, 148.4, 138.4, 126.1,124.1, 120.6, 114.2. LC/MS (ESI-) 283.9 (M+H)+.

As the paragraph descriping shows that 88982-82-5 is playing an increasingly important role.

Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica