Tag: M.W:0-100

288-47-1, Thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 2A; 2-Bromoacetylthiazole; The following is a large-scale adaptation of the Dondoni procedure cited above. A solution of bromoacetyl bromide (57.6 g, 0.286 mol) in dry DCM (100 mL) was added at 0-60C to a stirred solution of 2-trimethylsilylthiazole (37.4 g, 0.238 mol) in DCM (300 mL). After 2h at 0 0C, aqueous saturated NaHCO3 (1 L) was added and the resulting mixture was extracted with DCM (2 x 500 mL). The extracts were stirred with decolorizing carbon (Darco KB, 10 g) and filtered through Celite, and concentrated. The residue was purified by SGC (1.2 kg silica, 1:3 to 1:1 DCM-hexanes) giving 25.2 g of colorless crystalline solid (41%). 1H NMR (CDCI3, 400 mHz) delta 8.02 (d, 1H, J = 3.3 Hz), 7.74 (d, 1H, J = 3 Hz)1 4.69 (s, 2H). An alternate preparation was also achieved as follows. A solution of n-butyllithium (13.1 mL of 2.5 M in hexanes) was added at – 78 0C to a stirred solution of 2-thiazole (2.66 g, 31.25 mmol) in ether (26 mL). After 15 mi?, methyl bromoacetate (3.11 mL, 32.8 mmol) was added giving a light brown slurry which was warmed to RT and treated with acetic acid (3.6 mL) . Water (50 mL) and ether (30 mL) were added and the ether layer was separated, dried, and concentrated. The residue was suspended in hexanes (50 mL) at reflux and the hexanes decanted from a heavy oil. This was repeated and the hexanes combined and concentrated giving 4.9 g of light yellow needles (76%) having NMR identical to that described above plus minor impurities which could be removed by one trituration with 10 mL hexanes at RT.

288-47-1, As the paragraph descriping shows that 288-47-1 is playing an increasingly important role.

Reference：
Patent; PFIZER PRODUCTS INC.; WO2008/4117; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

288-47-1, Thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of 4-[2-(4-Nitro-phenyl)-6-oxo-4-thioxo-6H-1-thia-3,3b,5-triaza-cyclopenta[a]pentalen-5-yl]-butyric acid ethyl ester (Compound 37) As depicted in Scheme 24 below, anhydrous Co(OAc)2 (0.021 mmol, 5%) and SALEN (2,2′-(1,4-diiminobutane-1,4-diyl)diphenol, 0.041 mmol, 0.1 molequivalent) in 0.5 ml dry dioxane are placed in a flame-dried flask, and the mixture is stirred for 10 minutes at room temperature. A solution of thiazole (0.411 mmol) in 1 ml dry dioxane, anhydrous Cs2CO3 (0.493 mmol, 1.2 molequivalents) and CuI (0.822 mmol, 2 molequivalents) are thereafter added consecutively to the reaction mixture under argon. A solution of 4-nitrophenyl iodide (0.493 mmol, 1.2 molequivalents) in dry dioxane (0.5 ml) is then added dropwise and the resulting mixture is heated to 150 C. under argon, while monitoring the reaction progress by TLC. Once the reaction is completed (after about 10 hours), the resulting mixture is diluted with chloroform (20 ml) and filtered through a celite pad. The organic solvents are evaporated under reduced pressure and the crude product is purified by flash column chromatography, using a hexane:ethyl acetate mixture as eluent, to give pure 2-[4-nitrophenyl]thiazole.

288-47-1, The synthetic route of 288-47-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Gelder, Joel M. Van; Klein, Joseph Y.; Basel, Yochai; Reizelman, Anat; Tchilibon, Susanna; Mouallem, Orly; US2008/39456; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

288-47-1, Thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of Cs2CO3 (0.75 mmol) and CuI (1.25 mol%)in DMF (1.0 mL) was added aryl iodide (0.75 mmol), azole (0.5mmol) and 4a (0.25 mol%) under argon atmosphere at room temperature. Then the mixture was stirred at 120 C for 18 h. After cooling, filtration, and evaporation, the residue was purified by preparative TLC on silica gel plates eluting with petroleum ether/EtOAc to afford the corresponding products., 288-47-1

The synthetic route of 288-47-1 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Wang, Cong; Li, Yang; Lu, Beibei; Hao, Xin-Qi; Gong, Jun-Fang; Song, Mao-Ping; Polyhedron; vol. 143; (2018); p. 184 – 192;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.

(a) To a solution of n-butyllithium (24 ml, 0.06 mol, 2.5M in hexane) in 50 ml of ether under argon at -78 C. was added dropwise a solution of 5-methylthiazole (5 g, 0.05 mol) in 25 ml of ether. The mixture was stirred at -78 C. for 1 h, and then a solution of N-formyl-morpholine (5.5 ml 0.055 mol) in 30 ml of ether was added within 15 min. The mixture was stirred for 1 h at -78 C., then at 0–5 C. overnight. The reaction mixture was then extracted with 4N HCl (4*10 ml), the aqueous layers were combined, cooled in an ice-bath, and neutralized with sodium bicarbonate solution (pH 9). The aqueous layer was extracted with ether (4*20 ml), the organic layer was dried over magnesium sulfate and concentrated in vacuo. The residue was dried in vacuo to afford 4.5 g (70.8%%) of 5-methyl-2-thiazolylcarboxaldehyde.

3581-89-3, As the paragraph descriping shows that 3581-89-3 is playing an increasingly important role.

Reference：
Patent; Sterling Winthrop Inc.; US5569655; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

288-47-1, Thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,288-47-1

The 5-amino-2-tolyl 2-thiazolylmethyl ether used as a starting material was obtained as follows: A solution of thiazole (5 g) in diethyl ether (50 ml) was added dropwise to n-butyl lithium (1.6M in hexane, 30 ml) which had been cooled to -70 C. and the mixture was stirred at -70 C. for 3 hours. Formaldehyde gas ?obtained by heating paraformaldehyde (5.05 g) to 140 C.! was led into the reaction mixture and the resultant mixture was allowed to warm to ambient temperature and was stirred for 16 hours. The mixture was partitioned between diethyl ether and 4M aqueous hydrochloric acid. The aqueous layer was basified by adding aqueous potassium hydroxide solution and extracted with a mixture of ethyl acetate (80 ml), chloroform (20 ml) and ethanol (20 ml). The extract was evaporated to give 2-thiazolylmethanol (.4.4 g), m.p. 46-47 C.;

The synthetic route of 288-47-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Zeneca Limited; US5821246; (1998); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.

To a solution of bromide from Step 1 (18 g, 86 [MMOL)] in toluene (100 mL) was added thiourea (10.5 g, 138 [MMOL).] The reaction mixture was heated to [100C] for 1 h, cooled to rt, and the solvent removed under reduced pressure. The residue was dissolved in [CH2CI2] (100 mL), a saturated solution of [NAHC03] (75 mL) was added, and the mixture was vigorously stirred for 10 minutes. The organic layer was separated, dried [(NA2SO4),] filtered, and concentrated under reduced pressure. The residue was then recrystallized from [CH2CI2/HEXANES] to provide the product (10 g, 63%) as a white solid. [(C7H10N202S)] : LC-MS, RT 0.76 min, (M+H) [+] 187.0 ;’H NMR [(CDCI3)] : [6] 2.23 (s, 3H), 3.70 (s, 2H), 3.75 (s, 3H), 4.83-4. 95 (broad s, 2H)., 3581-89-3

As the paragraph descriping shows that 3581-89-3 is playing an increasingly important role.

Reference：
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2004/11446; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.

To a solution of BuLi (1.6 M in hexanes, 12.6 mL, 20.2 mmol) in 25mL of diethyl ether at -78 0C, was added a solution of 5-methylthiazole (2.0 g, 20.2 mmol) in ether (6 mL), drop-wise and stirred at -78 0C for 1.5 h. A solution of DMF (2.33 mL, 30.3 mmol in ether (5 mL) was added at once and the reaction mixture was allowed to warm to room temperature and stirred overnight. Ice was added to the reaction mixture followed by the slow addition of 4N HCl. The mixture was taken up in a separating funnel, ether added (30 mL) and shaken. The organic layer was discarded. The aqueous layer was brought to pH -7.5 with solid NaHCO3 and extracted with ether twice. The ether layer was dried over Na2SO4 and concentrated, and the resulting crude 5-methylthiazole-2-carbaldehyde (1.6 g) was carried over to the next- step without purification., 3581-89-3

The synthetic route of 3581-89-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3581-87-1, Name is 2-Methylthiazole, molecular formula is C4H5NS. In a Patent，once mentioned of 3581-87-1, Quality Control of: 2-Methylthiazole

The invention relates to compounds of formula wherein the substituents are as described in claim 1. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of beta-amyloid in the brain, in particular Alzheimer”s disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 3581-87-1 is helpful to your research., Quality Control of: 2-Methylthiazole

Reference：
Thiazole | C3H3679NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3581-87-1, Name is 2-Methylthiazole, molecular formula is C4H5NS. In a Article，once mentioned of 3581-87-1, category: thiazole

2-Methyl-1,3-thiazole, 2,4-dimethyl-1,3-thiazole, 2,4,5-trimethyl-1,3- thiazole, 2,4,5-trimethyl-1,3-oxazole, 2-methyl-1,3-benzoxazole and 2-methyl-1,3-benzothiazole were each treated with benzoyl chloride in acetonitrile containing triethylamine to give the corresponding (Z)-2-(heterocyclic)-1-phenylvinyl benzoates. Base hydrolysis of these vinyl benzoates gave the corresponding 2-(heterocyclic)-1-phenylethenols, which exist in both keto and enol tautomeric forms. These tautomers were used as starting materials for the syntheses of fused-ring heterocycles. The reactivity of the keto-enol tautomers depends on the nature of the heteroatom and the substituents that are present on the ring. Each tautomeric pair reacts with dimethyl acetylenedicarboxylate (DMAD) in methanol to give the 5,6-ring-fused 8-benzoyl-5-oxo-5H-thiazolo- and 8-benzoyl-5-oxo-5H-oxazolopyridinecarboxylate, 4-benzoyl-1-oxo-1H-pyrido[2,1-b]benzoxazolecarboxylate and 4-benzoyl-1-oxo-1H- pyrido[2,1-b]benzothiazolecarboxylate derivatives. Two novel 5,7-ring-fused compounds, tetramethyl 9-benzoyl-2,3-dimethyl-5,6-dihydrothiazolo[3,2-a]azepine- 5,6,7,8-tetracarboxylate and its oxazole analogue, were also obtained when the tautomers formed from 2,4,5-trimethyl-1,3-thiazole and 2,4,5-trimethyl-1,3- oxazole, respectively, were treated with DMAD. Reactions of the tautomers with methyl propiolate did not, however, give satisfactory results. Georg Thieme Verlag Stuttgart. New York.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: thiazole, you can also check out more blogs about3581-87-1

Reference：
Thiazole | C3H3775NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3581-87-1, Name is 2-Methylthiazole, molecular formula is C4H5NS. In a Patent，once mentioned of 3581-87-1, category: thiazole

Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: thiazole, you can also check out more blogs about3581-87-1

Reference：
Thiazole | C3H3746NS – PubChem,
Thiazole | chemical compound | Britannica