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The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator

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Reference:
Thiazole | C3H3647NS – PubChem,
Thiazole | chemical compound | Britannica

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Plant and insect controlling compositions comprising delta-aminolevulinic acid and/or one or more chlorophyll and porphyrin-heme biosynthesis modulators; and methods of making and using the compositions.

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Reference:
Thiazole | C3H3707NS – PubChem,
Thiazole | chemical compound | Britannica

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A Pd/PCy3/Ag2CO3 (Cy = cyclohexyl) catalytic system was found to promote decarboxylative arylation through the combination of decarboxylation and C-H bond functionalization. This protocol features a good substrate scope of aromatic carboxylic acids as well as a broad range of functional groups and provides the products in high yields. Copyright

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Reference:
Thiazole | C3H3757NS – PubChem,
Thiazole | chemical compound | Britannica

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An efficient synthesis of 2-hetarylquinazolin-4(3H)-ones via copper-catalyzed direct aerobic oxidative amination of sp3C-H bonds has been developed. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 2-hetaryl-substituted quinazolinones from easily available 2-aminobenzamides and (2-azaaryl)methanes.

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Reference:
Thiazole | C3H3743NS – PubChem,
Thiazole | chemical compound | Britannica

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Enzymatically hydrolysed wheat gluten hydrolysate (WGH) was deamidated using glutaminase to produce deamidated wheat gluten hydrolysate (DWGH). Volatile components were analysed in WGH and DWGH thermally reacted with glucose or fructose. In the reaction system containing glucose, 19 pyrazines, 2 furans, and 5 sulphur-containing components were detected in WGH, while 34 pyrazines, 4 furans, and 7 sulphur-containing components were found in DWGH. In the system containing fructose, 24 pyrazines, 3 furans, and 6 sulphur-containing components were identified in the thermal reaction of WGH, whereas 36 pyrazines, 4 furans, and 8 sulphur-containing components were found in DWGH. The volatile components increased in DWGH, both qualitatively and quantitatively, mainly due to free ammonia released by deamidation. More volatiles were also developed in WGH and DWGH with fructose than with glucose. It was found that ammonia released from wheat protein via deamidation participated in the generation of diverse volatile components including pyrazines in the Maillard reaction.

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Reference:
Thiazole | C3H3729NS – PubChem,
Thiazole | chemical compound | Britannica

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A qualitative study of volatile compounds in three commercial yeast extracts and autolysates was performed by solid-phase microextraction-gas chromatography with mass spectrometric and olfactometric detection; their addition to white wines and their effect on wine aroma composition were investigated by analytical, olfactometric and sensory evaluations. More than 160 volatile compounds were detected in the headspace of the commercial powders (some not previously reported in literature), and their olfactory characters were described. Yeast derivatives strongly modified wine aroma composition, either affecting the volatility of wine aroma compounds or by releasing exogenous volatiles. Dosage appeared to be fundamental: low amounts increased the volatility of some esters, giving more flowery and fruity notes to the wine; higher amounts increased fatty acid content in the wine headspace, producing yeasty, herbaceous and cheese-like smells. Sensory tests demonstrated that yeast derivatives would not be suitable for wines with a typical varietal aroma.

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Reference:
Thiazole | C3H3755NS – PubChem,
Thiazole | chemical compound | Britannica

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Optical properties, such as the real and imaginary parts of the dielectric function and the optical energy band gap, of new heterocyclic azo dyes thin films were investigated using spectroscopic ellipsometry combined with transmittance measurements. The topography of studied compounds was also examined by atomic force microscopy. It was found that the optical properties of the azo dyes materials strongly depend on the type of substitution in the azobenzene moiety, namely leads to a change in the value of refractive index, as well as bathochromic shifts of the absorption structure.

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Reference:
Thiazole | C3H3711NS – PubChem,
Thiazole | chemical compound | Britannica

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2-Methyl-1,3-thiazole, 2,4-dimethyl-1,3-thiazole, 2,4,5-trimethyl-1,3- thiazole, 2,4,5-trimethyl-1,3-oxazole, 2-methyl-1,3-benzoxazole and 2-methyl-1,3-benzothiazole were each treated with benzoyl chloride in acetonitrile containing triethylamine to give the corresponding (Z)-2-(heterocyclic)-1-phenylvinyl benzoates. Base hydrolysis of these vinyl benzoates gave the corresponding 2-(heterocyclic)-1-phenylethenols, which exist in both keto and enol tautomeric forms. These tautomers were used as starting materials for the syntheses of fused-ring heterocycles. The reactivity of the keto-enol tautomers depends on the nature of the heteroatom and the substituents that are present on the ring. Each tautomeric pair reacts with dimethyl acetylenedicarboxylate (DMAD) in methanol to give the 5,6-ring-fused 8-benzoyl-5-oxo-5H-thiazolo- and 8-benzoyl-5-oxo-5H-oxazolopyridinecarboxylate, 4-benzoyl-1-oxo-1H-pyrido[2,1-b]benzoxazolecarboxylate and 4-benzoyl-1-oxo-1H- pyrido[2,1-b]benzothiazolecarboxylate derivatives. Two novel 5,7-ring-fused compounds, tetramethyl 9-benzoyl-2,3-dimethyl-5,6-dihydrothiazolo[3,2-a]azepine- 5,6,7,8-tetracarboxylate and its oxazole analogue, were also obtained when the tautomers formed from 2,4,5-trimethyl-1,3-thiazole and 2,4,5-trimethyl-1,3- oxazole, respectively, were treated with DMAD. Reactions of the tautomers with methyl propiolate did not, however, give satisfactory results. Georg Thieme Verlag Stuttgart. New York.

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Reference:
Thiazole | C3H3775NS – PubChem,
Thiazole | chemical compound | Britannica

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Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

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Reference:
Thiazole | C3H3746NS – PubChem,
Thiazole | chemical compound | Britannica

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Nuclear magnetic resonance (NMR) spectroscopy has been established as a potent method for the determination of foldamer structures in solution. However, the NMR techniques could be limited by averaging, so additional experimental techniques are often needed to fully endorse the folding properties of a sequence. We have recently demonstrated that oligo-gamma-peptides composed of 4-amino(methyl)-1,3-thiazole-5-carboxylic acids (ATCs) adopt an original helical fold stabilized by hydrogen bonds forming C9 pseudocycles. The main objective of the present work is to reinvestigate the folding of ATC oligomer 1 in order to identify reliable FT-IR and NMR structural markers that are of value for tracking the degree of organization of ATC-based peptides.

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Reference:
Thiazole | C3H3714NS – PubChem,
Thiazole | chemical compound | Britannica