Tag: M.W=100-150

Felts, Andrew S.; Rodriguez, Alice L.; Morrison, Ryan D.; Blobaum, Anna L.; Byers, Frank W.; Daniels, J. Scott; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A. published the artcile< Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5>, Name: 4-Cyclopropylthiazol-2-amine, the main research area is pyrimidinylmethylquinolinecarboxamide preparation neg allosteric modulator glutamate receptor mGluR5; Central nervous system (CNS); G protein-coupled receptor (GPCR); Metabotropic glutamate receptor subtype 5 (mGlu(5)); Negative allosteric modulator (NAM); Quinoline.

Based on previous work that established fused heterocycles as viable alternatives for the picolinamide core of the authors’ lead series of mGlu5 neg. allosteric modulators (NAMs), the authors designed a novel series of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide mGlu5 NAMs. These new quinoline derivatives also contained carbon linkers as replacements for the diaryl ether oxygen atom common to the authors’ previously published chemotypes. Compounds were evaluated in a cell-based functional mGlu5 assay, and an exemplar analog 27 (6-(difluoro(pyrimidin-5-yl)methyl)-N-(4-methylthiazol-2-yl)quinoline-8-carboxamide) was >60-fold selective vs. the other seven mGlu receptors. Selected compounds were also studied in metabolic stability assays in rat and human S9 hepatic fractions and exhibited a mixture of P 450- and non-P 450-mediated metabolism

Bioorganic & Medicinal Chemistry Letters published new progress about Allosterism. 324579-90-0 belongs to class thiazole, and the molecular formula is C6H8N2S, Name: 4-Cyclopropylthiazol-2-amine.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mann, Joseph L.; Grosskopf, Abigail K.; Smith, Anton A. A.; Appel, Eric A. published the artcile< Highly Branched Polydimethylacrylamide Copolymers as Functional Biomaterials>, Application of C3H5NS2, the main research area is branched polydimethylacrylamide copolymer biomaterial.

Controlled radical polymerization of vinyl monomers with multivinyl cross-linkers leads to the synthesis of highly branched polymers with controlled spatial d. of functional chain ends. The resulting polymers synthesized in this manner have large dispersities resulting from a mixture of unreacted primary chains, low mol. weight branched species, and high mol. weight highly branched species. Through the use of fractional precipitation, we present a synthetic route to high mol. weight highly branched polymers that are absent of low mol. weight species and that contain reactivity toward amines for controlled postpolymn. modification. The controlled spatial d. of functional moieties on these high mol. weight macromol. constructs enable new functional biomaterials with the potential for application in regenerative medicine, immunoengineering, imaging, and controlled drug delivery.

Biomacromolecules published new progress about Biocompatibility. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Application of C3H5NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kikelj, D.; Urleb, U. published the artcile< Product class 17: thiazoles>, Application of C4H3NOS, the main research area is review thiazole preparation.

A review of synthetic methods to prepare thiazoles as well as reactive modifications of thiazole moieties.

Science of Synthesis published new progress about Cyclization. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Application of C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jiang, Xingyu; Beiger, Jason J.; Hartwig, John F. published the artcile< Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis>, HPLC of Formula: 1003-32-3, the main research area is stereodivergent allylic substitution iridium Lewis base; chiral allyl arylacetic ester preparation mol crystal structure; iridium Lewis base stereodivergent allylic substitution synergistic catalyst.

The preparation of all possible stereoisomers of a given chiral mol. bearing multiple stereocenters by a simple and unified method is a significant challenge in asym. catalysis. We report stereodivergent allylic substitutions with aryl acetic acid esters catalyzed synergistically by a metallacyclic iridium complex and benzotetramisole. Through permutations of the enantiomers of the two chiral catalysts, all four stereoisomers of the products bearing two adjacent stereocenters, e.g., I, are accessible with high diastereoselectivity and enantioselectivity. The resulting chiral activated ester products can be converted readily to enantioenriched amides, unactivated esters, and carboxylic acids in a one-pot manner.

Journal of the American Chemical Society published new progress about Allylic substitution reaction (stereoselective). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, HPLC of Formula: 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ho, Ginny D.; Michael Seganish, W.; Bercovici, Ana; Tulshian, Deen; Greenlee, William J.; Van Rijn, Rachel; Hruza, Alan; Xiao, Li; Rindgen, Diane; Mullins, Deborra; Guzzi, Mario; Zhang, Xiaoping; Bleickardt, Carina; Hodgson, Robert published the artcile< The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia>, Quality Control of 1003-32-3, the main research area is phosphodiesterase inhibitor schizophrenia dihydroimidazoisoquinoline derivative preparation SAR.

The identification of potent and orally active dihydroimidazoisoquinolines as PDE 10A inhibitors is reported. The SAR development led to the discovery of compound 35 (I) as a potent, selective, and orally active PDE10A inhibitor. Compound 35 inhibited MK-801-induced hyperactivity at 3 mg/kg and displayed a 10-fold separation between the minimal EDs for inhibition of MK-801-induced hyperactivity and hypolocomotion in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Antipsychotics. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Quality Control of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Agarwal, Sameer; Pethani, Jignesh P.; Shah, Hardik A.; Vyas, Vismit; Sasane, Santosh; Bhavsar, Harsh; Bandyopadhyay, Debdutta; Giri, Poonam; Viswanathan, Kasinath; Jain, Mukul R.; Sharma, Rajiv published the artcile< Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor>, SDS of cas: 1003-32-3, the main research area is oral bioavailable NLRP3 inflammasome inhibitor synthesis alkenyl sulfonylurea; Acute respiratory distress syndrome (ARDS); Coronavirus disease 2019 (COVID-19); Inflammation; Interleukin-1β (IL-1β); NLRP3; NLRP3 inflammasome; Sulfonylurea.

NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases, including COVID-19. In this study, rationally designed alkenyl sulfonylurea derivatives were identified as novel, potent and orally bioavailable NLRP3 inhibitors. Compound 7 (I) was found to be potent (IL-1β IC50 = 35 nM; IL-18 IC50 = 33 nM) and selective NLRP3 inflammasome inhibitor with excellent pharmacokinetic profile having oral bioavailability of 99% in mice.

Bioorganic & Medicinal Chemistry Letters published new progress about Acute respiratory distress syndrome. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, SDS of cas: 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mapesa, Emmanuel U.; Street, Dayton P.; Heres, Maximilian F.; Kilbey, S. Michael; Sangoro, Joshua published the artcile< Wetting and Chain Packing across Interfacial Zones Affect Distribution of Relaxations in Polymer and Polymer-Grafted Nanocomposites>, Category: thiazole, the main research area is wetting chain packing interface distribution PMMA silica graft nanocomposite.

Polymers exhibit deviations from their bulk phys. properties in the vicinity of solid interfaces due to changes in configurations, entanglements, and relaxation dynamics at the interfacial regions. By comparing grafted and nongrafted polymer nanocomposite systems based on poly(Me methacrylate) and silica, we show that the distribution of relaxation times exhibits both commonly reported slower mobility and faster modes that depend on the nature of the interfacial zone, matrix mol. weight, and loading level of nanomaterials. These findings are derived from studies using broadband dielec. spectroscopy (BDS) and differential scanning calorimetry (DSC) to probe mol. and interfacial dynamics. By systematically examining nanocomposites based on nonfunctionalized “”bare”” Si nanoparticles (NPs) dispersed in PMMA matrixes and on PMMA-grafted Si NPs (PMMA-g-NPs) in PMMA matrixes, we probe the effects of interfacial interactions and confinement in each of these cases on the glass transition temperature, Tg, the mean time scales, and spectral shapes of the dielec. relaxation. The faster relaxation modes are attributed to the increasing importance of chain wetting and packing in the interfacial zones around nanofillers, especially in the polymer-grafted system. These insights are used to generate a unifying mol. framework that explains the enhancement in numerous macroscopic phys. properties of polymer and polymer-grafted nanocomposites, which suits them for myriad applications.

Macromolecules (Washington, DC, United States) published new progress about Dielectric loss. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bogolubsky, Andrey V.; Moroz, Yurii S.; Savych, Olena; Pipko, Sergey; Konovets, Angelika; Platonov, Maxim O.; Vasylchenko, Oleksandr V.; Hurmach, Vasyl V.; Grygorenko, Oleksandr O. published the artcile< An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries>, SDS of cas: 324579-90-0, the main research area is hydantoin compound combinatorial synthesis Aurora kinase A inhibitor; 2,2,2-trifluoroethylcarbamates; amino esters; condensation; kinase inhibitors; nitrogen heterocycles.

An approach to the parallel synthesis of hydantoin libraries by reaction of in situ generated 2,2,2-trifluoroethylcarbamates and α-amino esters was developed. To demonstrate utility of the method, a library of 1158 hydantoins designed according to the lead-likeness criteria (MW 200-350, cLogP 1-3) was prepared The success rate of the method was analyzed as a function of physicochem. parameters of the products, and it was found that the method can be considered as a tool for lead-oriented synthesis. A hydantoin-bearing submicromolar primary hit acting as an Aurora kinase A inhibitor was discovered with a combination of rational design, parallel synthesis using the procedures developed, in silico and in vitro screenings.

ACS Combinatorial Science published new progress about Amidation. 324579-90-0 belongs to class thiazole, and the molecular formula is C6H8N2S, SDS of cas: 324579-90-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Takeda, Yasuyuki; Uoto, Kouichi; Iwahana, Michio; Jimbo, Takeshi; Nagata, Motoko; Atsumi, Ryo; Ono, Chiho; Tanaka, Noriko; Terasawa, Hirofumi; Soga, Tsunehiko published the artcile< New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 5>, Related Products of 1003-32-3, the main research area is taxoid preparation dihydrobaccatin acetal; taxane acetal preparation antitumor metabolic stability.

To improve the metabolic stability of I, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogs. Most of the synthetic compounds maintained excellent antitumor activity and were scarcely metabolized by human liver microsomes. And some compounds exhibited potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration similarly to I.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Related Products of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Rubing; Chen, Chengsheng; Zhang, Xiaojie; Zhang, Changde; Zhong, Qiu; Chen, Guanglin; Zhang, Qiang; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong published the artcile< Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents>, Safety of Thiazole-5-carboxyaldehyde, the main research area is pentadienone curcumin structure pharmacokinetics antitumor neoplasm.

Forty-three 1,5-diheteroaryl-1,4-pentadien-3-ones were designed as potential curcumin mimics, structurally featuring a central five-carbon dienone linker and two identical nitrogen-containing aromatic rings. They were synthesized using a Horner-Wadsworth-Emmons reaction as the critical step and evaluated for their cytotoxicity and antiproliferative activities toward both androgen-insensitive and androgen-sensitive prostate cancer cell lines and an aggressive cervical cancer cell line. Most of the synthesized compounds showed distinctly better in vitro potency than curcumin in the four cancer cell lines. The structure-activity data acquired from the study validated (1E,4E)-1,5-diheteroaryl-1,4-pentadien-3-ones as an excellent scaffold for in-depth development for clin. treatment of prostate and cervical cancers. 1-Alkyl-1H-imidazol-2-yl, ortho pyridyl, 1-alkyl-1H-benzo[d]imidazole-2-yl, 4-bromo-1-methyl-1H-pyrazol-3-yl, thiazol-2-yl, and 2-methyl-4-(trifluoromethyl)thiazol-5-yl were identified as optimal heteroaromatic rings for the promising in vitro potency. (1E,4E)-1,5-Bis(2-methyl-4-(trifluoromethyl)thiazol-5-yl)penta-1,4-dien-3-one, featuring thiazole rings and trifluoromethyl groups, was established as the optimal lead compound because of its good in vitro potency and attractive in vivo pharmacokinetic profiles.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Safety of Thiazole-5-carboxyaldehyde.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica