Tag: M.W=100-150

Zhang, Xiaoyu; Luukkonen, Lena M.; Eissler, Christie L.; Crowley, Vincent M.; Yamashita, Yu; Schafroth, Michael A.; Kikuchi, Shota; Weinstein, David S.; Symons, Kent T.; Nordin, Brian E.; Rodriguez, Joe L.; Wucherpfennig, Thomas G.; Bauer, Ludwig G.; Dix, Melissa M.; Stamos, Dean; Kinsella, Todd M.; Simon, Gabriel M.; Baltgalvis, Kristen A.; Cravatt, Benjamin F. published the artcile< DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras>, HPLC of Formula: 1003-32-3, the main research area is DCAF11 targeted protein degradation electrophilic PROTAC cancer.

Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have been found to support ligand-induced protein degradation, reflecting a dearth of E3-binding compounds for proteolysis-targeting chimera (PROTAC) design. Here, we describe a functional screening strategy performed with a focused library of candidate electrophilic PROTACs to discover bifunctional compounds that degrade proteins in human cells by covalently engaging E3 ligases. Mechanistic studies revealed that the electrophilic PROTACs act through modifying specific cysteines in DCAF11, a poorly characterized E3 ligase substrate adaptor. We further show that DCAF11-directed electrophilic PROTACs can degrade multiple endogenous proteins, including FBKP12 and the androgen receptor, in human prostate cancer cells. Our findings designate DCAF11 as an E3 ligase capable of supporting ligand-induced protein degradation via electrophilic PROTACs.

Journal of the American Chemical Society published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, HPLC of Formula: 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pola, Robert; Kral, Vlastimil; Filippov, Sergey K.; Kaberov, Leonid; Etrych, Tomas; Sieglova, Irena; Sedlacek, Juraj; Fabry, Milan; Pechar, Michal published the artcile< Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells>, SDS of cas: 96-53-7, the main research area is polymer tumor targeting antibody ganglioside GD2.

A water-soluble polymer cancerostatic actively targeted against cancer cells expressing a disialoganglioside antigen GD2 was designed, synthesized and characterized. A polymer conjugate of an antitumor drug doxorubicin with a N-(2-hydroxypropyl)methacrylamide-based copolymer was specifically targeted against GD2 antigen-pos. tumor cells using a recombinant single chain fragment (scFv) of an anti-GD2 monoclonal antibody. The targeting protein ligand was attached to the polymer-drug conjugate either via a covalent bond between the amino groups of the protein using a traditional nonspecific aminolytic reaction with a reactive polymer precursor or via a noncovalent but highly specific interaction between bungarotoxin covalently linked to the polymer and the recombinant scFv modified with a C-terminal bungarotoxin-binding peptide. The GD2 antigen binding activity and GD2-specific cytotoxicity of the targeted noncovalent polymer-scFv complex proved to be superior to the covalent polymer-scFv conjugate.

Biomacromolecules published new progress about Antibody-drug conjugates. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, SDS of cas: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hoseinzadeh, A. R.; Javadpour, S. published the artcile< Electrochemical, thermodynamic and theoretical study on anticorrosion performance of a novel organic corrosion inhibitor in 3.5% NaCl solution for carbon steel>, SDS of cas: 96-53-7, the main research area is carbon steel sodium chloride corrosion inhibitor electrochem anticorrosion property.

The theor. and electrochem. performance of a novel organic corrosion inhibitor 3,4-dihydro-3-[2-mercaptothiazolidine]indol-2-one (DMI), for API 5L Grade B carbon steel in 3.5% NaCl, was evaluated by potentiodynamic polarization (Tafel), electrochem. impedance spectroscopy (EIS) and d. functional theory (DFT) for quantum chem. studies. Potentiodynamic studies confirmed that DMI was a mixed organic corrosion inhibitor type which specially affects the cathodic branch. The inhibition efficiencies of reactants, DMI and acetylcysteine followed the following order at 25oC and 200 ppm: DMI (87%) > isatin (71%) > 2-thiazoline-2-thiol (62%) > acetylcysteine (54%). EIS measurements illustrated the charge transfer controlled corrosion process. The Langmuir adsorption isotherm model of DMI was adopted. Surface studies were performed using SEM. Activation and adsorption thermodn. parameters of DMI were computed. The magnitude of ΔGoads and the sign of ΔHoads concluded that the adsorption occurred through chemisorption. Quantum chem. calculations of four corrosion inhibitors were used for investigating the mol. structure effect on inhibition efficiency.

Bulletin of Materials Science published new progress about Adsorption. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, SDS of cas: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Xu, Pengfei; Shen, Pei; Wang, Hai; Qin, Lian; Ren, Jie; Sun, Qiushuang; Ge, Raoling; Bian, Jinlei; Zhong, Yi; Li, Zhiyu; Wang, JuBo; Qiu, Zhixia published the artcile< Discovery of imidazopyrrolopyridines derivatives as novel and selective inhibitors of JAK2>, Recommanded Product: Thiazole-5-carboxyaldehyde, the main research area is imidazopyrrolopyridine preparation JAK2 inhibitor SAR mol docking; Imidazopyrrolopyridine; Janus kinase 2 (JAK2); Kinase; Myeloproliferative neoplasms; Selectivity.

Herein,the design, synthesis, and structure-activity relationships of a series of imidazopyrrolopyridines derivatives I [R1 = H, cyclopropyl, 2-chlorophenyl, etc.; R2 = cyanomethyl, 4,4,4-trifluorobutyl, (3-(cyanomethyl)-1-ethylsulfonyl-azetidin-3-yl), etc.] that selectively inhibit Janus kinase 2 (JAK2) was described . These screening cascades revealed that I [R1 = H; R2 = 3-cyanopropyl] was a preferred compound, with IC50 values of 10 nM for JAK2. Moreover, I [R1 = H; R2 = 3-cyanopropyl] was a selective JAK2 inhibitor with 19-fold, >30-fold and >30-fold selectivity over JAK1, JAK3 and TYK2 resp. In cytokine-stimulated cell-based assays, I [R1 = H; R2 = 3-cyanopropyl] exhibited a higher JAK2 selectivity over JAK1 isoforms. Indeed, at a dose of 20 mg/kg compound I [R1 = H; R2 = 3-cyanopropyl], pSTAT3 and pSTAT5 expression was reduced to levels comparable to those of control animals untreated with GM-CSF. Addnl., I [R1 = H; R2 = 3-cyanopropyl] showed a relatively good bioavailability (F = 38%), a suitable half-life time (T1/2 = 1.9 h), a satisfactory metabolic stability, suggesting that I [R1 = H; R2 = 3-cyanopropyl] might be a promising inhibitor of JAK2 for further development research for the treatment of MPNs.

European Journal of Medicinal Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Recommanded Product: Thiazole-5-carboxyaldehyde.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Funes-Maldonado, Matias; Sieng, Bora; Amedjkouh, Mohamed published the artcile< Enabling Asymmetric Alkynylation of Azaaryl Aldehydes with Soai Autocatalyst>, Electric Literature of 1003-32-3, the main research area is propargylic alc enantioselective preparation; azaaryl aldehyde dimethylzinc Soai pyrimidylalkanol chiral autocatalyst asym alkynylation.

Synthesis of enantioenriched propargylic alcs. I [R1 = Ph, Si(CH3)3; R2 = 3-pyridyl, thiazol-5-yl, 3-quinolyl, etc.] via enantioselective addition of alkynylzinc reagents to azaaryl aldehydes using Soai (R)-(5-pyrimidyl)alkanol as a chiral catalyst was reported. The autocatalyst can be generated from almost racemic environment to up to 99.5% ee and subsequently propagates this chirality to provide propargylic alcs. in up to 86% ee.

European Journal of Organic Chemistry published new progress about Alcohols, propargyl Role: SPN (Synthetic Preparation), PREP (Preparation). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Electric Literature of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zou, Luyi; Zhang, Xiaoyue; Shao, Mingying; Sun, Ruirui; Zhu, Yuting; Zou, Binbin; Huang, Zhenxing; Liu, He; Teng, Yue published the artcile< A biophysical probe on the binding of 2-mercaptothioazoline to bovine hemoglobin>, Application In Synthesis of 96-53-7, the main research area is mercaptothioazoline bovine Hb physiol function; 2-Mercaptothioazoline; Binding interaction; Conformation investigation; Hemoglobin; Molecular modeling; Spectroscopic studies.

2-Mercaptothiazoline (MTZ) is broadly present in daily use as an antifungal reagent, a brightening agent, and a corrosion inhibitor. MTZ is potentially harmful for human health. Although the toxic effects of MTZ on exptl. animals have been reported, the effects of MTZ on the proteins in the circulatory system at the mol. level have not been identified previously. Here, we explored the interaction of MTZ with bovine Hb (BHb) in vitro using multiple spectroscopic techniques and mol. docking. In this study, the binding capacity, acting force, binding sites, mol. docking simulation, and conformational changes were investigated. MTZ quenched the intrinsic emission of BHb via the static quenching process and could spontaneously bind with BHb mainly through van der Waals forces and hydrogen bond. The computational docking visualized that MTZ bound to the β2 subunit of BHb, which further led to some changes of the skeleton and secondary structure of BHb. This research provides valuable information about the mol. mechanisms on BHb induced by MTZ and is beneficial for clarifying the toxicol. actions of MTZ in blood.

Environmental Science and Pollution Research published new progress about Absorption. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Application In Synthesis of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Jing; Jiang, Huihui; Liu, Hai-Bo; Liang, Lebao; Tao, Junrong published the artcile< Pyrene-imidazole conjugate as a fluorescent sensor for the sequential detection of iron(III) and histidine in aqueous solution>, Related Products of 96-53-7, the main research area is pyrene imidazole conjugate fluorescent sensor iron histidine; Ensemble; Fe(3+) ions; Histidine; Imidazole; Pyrene; Structure-activity relationships.

We developed PIM (I), a pyrene-based fluorescence sensor bearing an imidazole moiety and a carbonyl group as the binding sites for Fe3+ ions. The pyrene-based control compounds 1 and 2 were synthesized to demonstrate the structure-activity relationships. Compound 1 (II), which contained a thiazoline moiety and a carbonyl group, displayed high selectivity for Cu2+ ions. This property indicated that heterocycles play an important role in the metal ion selectivity modulation. Compound 2 (III), which lacked a carbonyl group, did not display metal ion selectivity. This characteristic demonstrated that introducing an addnl. recognition unit (cooperative recognition strategy) should be an effective way to improve metal ion selectivity. Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM. The sequential detection of Fe3+ and His exhibited on-off-on phenomenon, and the Fe3+ and His detection limits were 0.11 and 3.06 μM, resp. These results will help in the further enhancement or modulation of metal ion selectivity in the development of fluorescent sensor systems. Moreover, the organic-metal ensemble provides an effective platform for detecting amino acids through the displacement strategy.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Drinking waters (sample). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Related Products of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nguyen, William; Jacobson, Jonathan; Jarman, Kate E.; Jousset Sabroux, Helene; Harty, Leigh; McMahon, James; Lewin, Sharon R.; Purcell, Damian F.; Sleebs, Brad E. published the artcile< Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models>, COA of Formula: C6H10N2S, the main research area is acylaminothiazole TAT transcription HIV1 latency antiretroviral agent HIV infection.

The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART). Epigenetic targeted compounds have shown promise as potential latency-reversing agents; however, these drugs have undesirable toxicity and lack specificity for HIV. We utilized a novel HEK293-derived FlpIn dual-reporter cell line, which quantifies specific HIV provirus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to identify the 5-substituted 2-acylaminothiazole hit class. Here, we describe the optimization of the hit class, defining the functionality necessary for HIV gene activation and for improving in vitro metabolism and solubility The optimized compounds displayed enhanced HIV gene expression in HEK293 and Jurkat 10.6 latency cellular models and increased unspliced HIV RNA in resting CD4+ T cells isolated from HIV-infected individuals on ART, demonstrating the potential of the 2-acylaminothiazole class as latency-reversing agents.

Journal of Medicinal Chemistry published new progress about Anti-HIV agents. 101080-15-3 belongs to class thiazole, and the molecular formula is C6H10N2S, COA of Formula: C6H10N2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Londregan, Allyn T.; Piotrowski, David W.; Futatsugi, Kentaro; Warmus, Joseph S.; Boehm, Markus; Carpino, Philip A.; Chin, Janice E.; Janssen, Ann M.; Roush, Nicole S.; Buxton, Joanne; Hinchey, Terri published the artcile< Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries>, Synthetic Route of 1003-32-3, the main research area is phenoxydimethylpyrazolecarboxamide combinatorial preparation SAR TGR5 agonist.

Optimization of a high-throughput screening hit led to the discovery of a new series of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as highly potent agonists of TGR5. This novel chemotype was rapidly developed through iterative combinatorial library synthesis. It was determined that in vitro agonist potency correlated with functional activity data from human peripheral blood monocytes.

Bioorganic & Medicinal Chemistry Letters published new progress about Combinatorial library. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Synthetic Route of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lu, Zheng; Yang, Yong-Qing; Xiong, Weixiang published the artcile< Preparation of 1,3-Thiazolidine-2-thiones by Using Potassium Ethylxanthate as a Carbon Disulfide Surrogate>, HPLC of Formula: 96-53-7, the main research area is thiazolidine thione preparation green chem; amino alc potassium ethylxanthate heterocyclization.

A simple procedure is presented for preparing 1,3-thiazolidine-2-thiones, e.g., I by using potassium ethylxanthate and the corresponding β-amino alcs. as the starting materials in the presence of ethanol.

Synlett published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, HPLC of Formula: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica