Tag: M.W=100-150

Jiang, Xingyu; Hartwig, John F. published the artcile< Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates>, Related Products of 1003-32-3, the main research area is homoallylic ester regioselective diastereoselective enantioselective preparation; ester aliphatic silyl ketene acetal regioselective enantioselective allylic substitution; alkylation; asymmetric catalysis; enantioselectivity; esters; iridium.

An iridium-catalyzed enantioselective allylic substitution of aliphatic esters (E)-R1CH:CHCH2OC(O)Ph (R1 = Ph, 4-MeC6H4, 2-thienyl, 3-pyridyl, etc.) with silyl ketene acetals R22C:C(OR3)SiMe3 [R2 = Me, Et; R22 = (CH2)3, (CH2)5, (CH2)2O(CH2)2, etc.; R3 = Me, i-Pr, t-Bu, Ph, etc.] to form products containing a quaternary carbon atom at the nucleophile moiety and a tertiary carbon atom at the electrophile moiety is reported. Under relatively neutral conditions, the allylated aliphatic esters H2C:CHCH(R1)CR22CO2R3 were obtained with excellent regio- and enantioselectivity. These products were readily converted into primary alcs., carboxylic acids, amides, isocyanates, and carbamates, as well as THF and γ-butyrolactone derivatives, without erosion of enantiomeric purity.

Angewandte Chemie, International Edition published new progress about Acetals, ketene, silyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Related Products of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ma, Xiaohua; Ma, Fei; Zhao, Zhenhua; Song, Naiheng; Zhang, Jianping published the artcile< Synthesis and properties of NLO chromophores with fine-tuned gradient electronic structures>, Formula: C4H3NOS, the main research area is synthesis property NLO chromophores fine tuned gradient electronic structure.

A novel series of heterocycle-based NLO chromophores based on different combinations of auxiliary donor (i.e., benzene, thiophene and pyrrole) and auxiliary acceptor (i.e., thiazole with different regiochemistries) were designed and synthesized. Due to the different electron-rich and poor nature of the auxiliary donors and acceptors, resp., the resulting NLO chromophores have systematically varied ground-state electronic structures, as evidenced by the 1H NMR, CV and UV-vis investigations. The nonlinear optical properties of the resulting NLO chromophores were studied by UV-vis spectroscopy, Hyper-Rayleigh scattering (HRS), and semi-empirical computations. All the chromophores have very large mol. hyperpolarizabilities (β1000 nm) in the range of 704-1500 × 10-30 esu (or β0, 318-768 × 10-30 esu), which showed a great sensitivity to the gradient electronic structures. Upon increasing the electron d. from benzene to thiophene and to pyrrole, substantial increases in β0 were observed; significantly larger β0 values were also observed for NLO chromophores based on “”matched”” thiazole (C2 is connected to the acceptor) than those based on “”un-matched”” thiazole (C5 is connected to the acceptor). TGA investigations showed good thermal stability for the resulting NLO chromophores. However, with the increase of electron d. of the auxiliary donor, a decrease in thermal and photochem. stability was observed It is interesting to note that NLO chromophores based on triarylamine as the donor and thiazole as the auxiliary acceptor exhibited not only high thermal stability but also very large β0 values.

Journal of Materials Chemistry published new progress about Chromophores. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Formula: C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fray, M. Jonathan; Bish, Gerwyn; Fish, Paul V.; Stobie, Alan; Wakenhut, Florian; Whitlock, Gavin A. published the artcile< Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors>, Safety of Thiazole-5-carboxyaldehyde, the main research area is structure piperazine derivative dual serotonin noradrenaline reuptake inhibitor.

We report the structure-activity relationships of further analogs in a series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake, i.e., with addnl. substitution of the Ph rings, or their replacement by heterocycles. The enantiomers of compounds 1 and 2 were also profiled, and possessed drug-like physicochem. properties. In particular, compound (-)-2 lacked potent inhibitory activity against any of the important cytochromes P450 and high selectivity over a wide range of receptors, which is unusual for a compound that inhibits human amine transporters.

Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT reuptake inhibitors. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Safety of Thiazole-5-carboxyaldehyde.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Desaubry, Laurent; Wermuth, Camille G.; Boehrer, Annie; Marescaux, Christian; Bourguignon, Jean-Jacques published the artcile< Synthesis and anticonvulsant properties of BW A78U structurally-related compounds>, Application In Synthesis of 31825-95-3, the main research area is BW A78U analog anticonvulsant.

Several analogs, e.g. I, of the anticonvulsant BW A78U have been synthesized and tested for their anticonvulsant properties, providing preliminary data concerning the structural requirements for this family of drugs.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticonvulsants. 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Application In Synthesis of 31825-95-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Felts, Andrew S.; Rodriguez, Alice L.; Morrison, Ryan D.; Venable, Daryl F.; Manka, Jason T.; Bates, Brittney S.; Blobaum, Anna L.; Byers, Frank W.; Daniels, J. Scott; Niswender, Colleen M.; Jones, Carrie K.; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A. published the artcile< Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety>, HPLC of Formula: 324579-90-0, the main research area is anxiolytic mGlu5 modulator VU0409106 analog preparation anxiety; Allosteric modulator; Anxiety; CNS; Glutamate; mGlu(5).

Development of SAR in an aryl ether series of mGlu5 NAMs leading to the identification of tool compound VU0409106 is described in this Letter. VU0409106 is a potent and selective neg. allosteric modulator of mGlu5 that binds at the known allosteric binding site and demonstrates good CNS exposure following i.p. dosing in mice. VU0409106 also proved efficacious in a mouse marble burying model of anxiety, an assay known to be sensitive to mGlu5 antagonists as well as clin. efficacious anxiolytics.

Bioorganic & Medicinal Chemistry Letters published new progress about Anxiolytics. 324579-90-0 belongs to class thiazole, and the molecular formula is C6H8N2S, HPLC of Formula: 324579-90-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola published the artcile< A new convenient preparation of 2-, 4-, and 5-thiazolecarboxaldehydes and their conversion into the corresponding carbonitrile N-oxides: synthesis of 3-thiazolylisoxazoles and 3-thiazolylisoxazolines>, Name: Thiazole-5-carboxyaldehyde, the main research area is thiazolecarboxaldehyde; formylation lithiothiazole formylmorpholine; isoxazole thiazolyl; isoxazoline thiazolyl; cyclization nitrile oxide alkene alkyne.

The title aldehydes are prepared in high yields by quenching 2-lithio-thiazole, 4-lithio-, and 5-lithio-2-trimethylsilylthiazole with N-formylmorpholine followed by protodesilylation in the latter two cases. The aldehydes are transformed through their oximes and hydroxamoyl chlorides into nitrile oxides which react with alkene and acetylene dipolarophiles to give 3-thiazolylisoxazolines and 3-thiazolylisoxazoles.

Synthesis published new progress about Cycloaddition reaction. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Name: Thiazole-5-carboxyaldehyde.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jimenez, Andrew M.; Krauskopf, Alejandro A.; Perez-Camargo, Ricardo A.; Zhao, Dan; Pribyl, Julia; Jestin, Jacques; Benicewicz, Brian C.; Muller, Alejandro J.; Kumar, Sanat K. published the artcile< Effects of Hairy Nanoparticles on Polymer Crystallization Kinetics>, Electric Literature of 96-53-7, the main research area is hairy nanoparticle polymer crystallization kinetics.

We previously showed that nanoparticles (NPs) could be ordered into structures by using the growth rate of polymer crystals as the control variable. In particular, for slow enough spherulitic growth fronts, the NPs grafted with amorphous polymer chains are selectively moved into the interlamellar, interfibrillar, and interspherulitic zones of a lamellar morphol., specifically going from interlamellar to interspherulitic with progressively decreasing crystal growth rates. Here, we examine the effect of NP polymer grafting d. on crystallization kinetics. We find that while crystal nucleation is practically unaffected by the presence of the NPs, spherulitic growth, final crystallinity, and m.p. values decrease uniformly as the volume fraction of the crystallizable polymer, poly(ethylene oxide) or PEO, ϕPEO, decreases. A surprising aspect here is that these results are apparently unaffected by variations in the relative amounts of the amorphous polymer graft and silica NPs at constant ϕ, implying that chem. details of the amorphous defect apparently only play a secondary role. We therefore propose that the grafted NPs in this size range only provide geometrical confinement effects which serve to set the crystal growth rates and m.p. depressions without causing any changes to crystallization mechanisms.

Macromolecules (Washington, DC, United States) published new progress about Crystal nucleation. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hsieh, Sheng-Ying; Bode, Jeffrey W. published the artcile< Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents>, Related Products of 1003-32-3, the main research area is Lewis acid iridium thiomorpholine thiazepane photoredox catalyst.

The authors report that the inclusion of Lewis acids in photocatalytic reactions of organosilanes allows access to a distinct reaction pathway featuring an Ir(III)*/Ir(IV) couple instead of the previously employed Ir(III)*/Ir(II) pathway, enabling the transformation of aromatic and aliphatic aldehydes to thiomorpholines and thiazepanes. The role of the Lewis acid in accepting an electron-either directly or via coordination to an imine-can be extended to other classes of photocatalysts and transformations, including oxidative cyclizations. The combination of light induced reactions and Lewis acids therefore promises access to new pathways and transformations that are not viable using the photocatalysts alone.

ACS Central Science published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Related Products of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chadha, Ridhima; Das, Abhishek; Debnath, Anil K.; Kapoor, Sudhir; Maiti, Nandita published the artcile< 2-thiazoline-2-thiol functionalized gold nanoparticles for detection of heavy metals, Hg(II) and Pb(II) and probing their competitive surface reactivity: A colorimetric, surface enhanced Raman scattering (SERS) and x-ray photoelectron spectroscopic (XPS) study>, Category: thiazole, the main research area is colorimetry SERS 2thiazoline2thiol gold nanoparticles heavy metals surface reactivity.

A novel 2-thiazoline-2-thiol functionalized gold (Au-TT) nanosensor was developed for the selective and sensitive detection of toxic heavy metal ions, Hg(II) and Pb(II) by colorimetry, and for studying its competitive surface reactivity using SERS and XPS. The detection mechanism and surface reactivity is based on competitive binding affinity of thiocarbonyl S or thiazoline ring N/S atom with the metal ions and the nanoparticles (NPs). Due to diff ;erences in the binding affinities of the metal ions towards the active binding sites of TT, addition of different metal ions resulted in variation of color and SERS spectral features. Of the various metal ions studied, viz. Cu(II), Cd(II), Co(II), Zn(II), Ni(II), Hg(II), Pb(II), Ca(II), Fe(II), Mn(II) and Sn(II), only Hg(II) and Pb(II) showed distinctive colorimetric and SERS spectral response that was quantified using XPS. This study, thus, realizes a selective and sensitive visual based nanosensor for Hg(II) and Pb(II) with limit of detection (LOD) of ∼ 0.1 ppm. SERS revealed the formation of Hg(TT)2 and Pb(TT)2 complexes on the Au NPs surface with the former remaining bonded to the NPs, resulting in enhanced Raman intensity for the 1026 cm-1 band, while the latter gets desorbed from the surface leading to reduced SERS intensity.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about Affinity. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bedford, Simon T.; Benwell, Karen R.; Brooks, Teresa; Chen, Ijen; Comer, Mike; Dugdale, Sarah; Haymes, Tim; Jordan, Allan M.; Kennett, Guy A.; Knight, Anthony R.; Klenke, Burkhard; LeStrat, Loic; Merrett, Angela; Misra, Anil; Lightowler, Sean; Padfield, Anthony; Poullennec, Karine; Reece, Mark; Simmonite, Heather; Wong, Melanie; Yule, Ian A. published the artcile< Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor>, Quality Control of 1003-32-3, the main research area is thienopyrimidine aroyl carbamoyl alkylamino preparation antagonist human adenosine receptor.

The discovery of a novel class of antagonists of the human adenosine A2B receptor, thieno[3,2-d]pyrimidines I (R1 = Ph, 4-MeOC6H4, 2-thienyl, 5-methyl-2-thienyl, 2-thiazolyl, 4-pyridyl, MeNH, 1-pyrrolidinyl, etc.; R2 = H, Et, PhCH2, 3-pyridylmethyl, 3-pyridylcarbonyl, etc.; R3 = H, Cl, H2N, MeNH, EtNH, Me2N) is reported. This low mol. weight scaffold has been optimized to offer derivatives with potential utility for the alleviation of conditions associated with this receptor subtype, such as nociception, diabetes, asthma and COPD. Furthermore, preliminary pharmacokinetic anal. has revealed compounds with profiles suitable for either inhaled or systemic routes of administration.

Bioorganic & Medicinal Chemistry Letters published new progress about Adenosine A2B receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Quality Control of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica