Tag: M.W=100-150

Nicolaou, K. C.; Leung, Gulice Y. C.; Dethe, Dattatraya H.; Guduru, Ramakrishna; Sun, Ya-Ping; Lim, Chek Shik; Chen, David Y.-K. published the artcile< Chemical Synthesis and Biological Evaluation of Palmerolide A Analogues>, Product Details of C5H6N2OS, the main research area is palmerolide A analog preparation antitumor.

Mol. design and chem. synthesis of several palmerolide A analogs allowed the first structure activity relationships (SARs) of this newly discovered marine antitumor agent. From several analogs synthesized and tested, compounds I (with a Ph substituent on the side chain) and II (lacking the C-7 hydroxyl group) were the most interesting, exhibiting approx. a 10-fold increase in potency and equipotency, resp., to the natural product. These findings point the way to more focused structure activity relationship studies.

Journal of the American Chemical Society published new progress about Antitumor agents. 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Product Details of C5H6N2OS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ormond, Alexandra B.; Freeman, Harold S. published the artcile< Effects of substituents on the photophysical properties of symmetrical porphyrins>, Product Details of C4H3NOS, the main research area is singlet oxygen generation sym porphyrin photosensitizer; substituent effect photophys sym porphyrin derivative.

Porphyrin compounds having groups that mimic the phenolic moiety of m- and p-isomers of 5,10,15,20-tetrakis(hydroxyphenyl) porphyrin (THPP) have been synthesized along with 5,10,15,20-tetrakis(heteroaryl) porphyrins bearing 2-thienyl and 5-thiazolyl groups. Absorption and fluorescence spectroscopy, including fluorescence lifetime (τf) and quantum yield (Φf) measurements, were employed to characterize the singlet excited state of all compounds, using 5,10,15,20-tetraphenylporphyrin (H2TPP) as a standard (Φf = 0.12 in DMF). The generation of singlet oxygen by each porphyrin photosensitizer was measured as the singlet oxygen quantum yield (ΦΔ), using H2TPP as a standard (ΦΔ = 0.64 in DMF). Partition coefficients were determined using 2-octanol as the organic phase and PBS solution as the aqueous phase. Fluorescence quantum yields ranged from 0.01 to 0.18 for all compounds, with heteroaryl porphyrins having the lowest values. Singlet oxygen quantum yields ranged from 0.40 to 0.65, with heteroaryl porphyrins having the highest values, showing them to be better sensitizers than m- and p-THPP. Log P values were all >1 showing higher solubility in the 2-octanol layer.

Dyes and Pigments published new progress about Excited singlet state. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Product Details of C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lee, Hyojin; Kim, Ki Hun; Lee, Kwan Hyi published the artcile< Non-invasive molecular barcode assay for diagnosis of sex hormones correlated with precocious puberty>, Reference of 96-53-7, the main research area is testosterone estradiol diagnosis noninvasive mol barcode assay precocious puberty.

Precocious puberty treatment in children faces several diagnostic and therapeutic challenges. For an efficient prognosis of the disease, early diagnosis must be accompanied by properly timed treatment. Sex hormones are markers that are used to diagnose precocious puberty. Detection methods usually require multiple blood samples from the patient over a 90-120-min time interval. The test is painful and uncomfortable for children, and is relatively expensive and time-consuming. Herein, we introduce a new bio-barcode method that is a non-invasive, fast, highly-sensitive, and is capable of multiplex detection of steroid sex hormones in urine using gold nanoparticles. We compared three different barcode assay approaches to determine the barcode mols.: gel electrophoresis, fluorescence-based solution assay, and liquid chromatog.-mass spectrometry (LC-MS). The gel electrophoresis approach was cost-effective but could not quantify the absolute levels of hormones. The other methods permitted quant. comparison between samples. LC-MS displayed the highest sensitivity. For the LC-MS anal., we grafted two chem. compounds as surrogate mols. onto the surface of 50-nm gold nanoparticles. Approx. 7-9 million chem. mols. were loaded on each nanoparticle, which amplified the LC-MS signal. The LC-MS could detect hormones levels which were 10,000-fold lower than the levels detected by the conventional method. The barcode assay could determine multiple analytes simultaneously without any sample preparation step. Importantly, this is first finding that uses barcode mols.-conjugated nanoparticles to amplify the mass spectrometer signal. The result is significant as it has implications for its principle and methodol., which utilizes non-invasive procurement protocols, can be applied to not only sex hormones, but other hormones which require will ultrasensitive detection. We anticipate that our research findings, which use a painless and economic detection method, can contribute to the early and accurate diagnosis of precocious puberty.

Sensors and Actuators, B: Chemical published new progress about Diagnosis Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Reference of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Liu, Jianhua; Kotrchova, Lenka; Lecuyer, Thomas; Corvis, Yohann; Seguin, Johanne; Mignet, Nathalie; Etrych, Tomas; Scherman, Daniel; Randarova, Eva; Richard, Cyrille published the artcile< Coating persistent luminescence nanoparticles with hydrophilic polymers for in vivo imaging>, Name: 4,5-Dihydrothiazole-2-thiol, the main research area is zinc gallium oxide chromium hydrophilic polymer optical property; HPMA polymer; imaging; in vivo; nanoparticles; persistent luminescence; surface coating.

Persistent luminescence nanoparticles (PLNPs) are innovative nanomaterials highly useful for bioimaging applications. Indeed, due to their particular optical properties, i.e., the ability to store the excitation energy before slowly releasing it for a prolonged period of time, they allow in vivo imaging without auto-fluorescence and with a high target to background ratio. However, as for most nanoparticles (NPs), without any special surface coating, they are rapidly opsonized and captured by the liver after systemic injection into small animals. To overcome this issue and prolong nanoparticle circulation in the bloodstream, a new stealth strategy was developed by covering their surface with poly(N-2-hydroxypropyl)methacrylamide (pHPMA), a highly hydrophilic polymer widely used in nanomedicine. Preliminary in vivo imaging results demonstrated the possibility of pHPMA as an alternative strategy to cover ZnGa2O4:Cr NPs to delay their capture by the liver, thereby providing a new perspective for the formulation of stealth NPs.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Biological imaging. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Name: 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sarkar, Sudeep; Wojciechowska, Natalia; Rajkiewicz, Adam A.; Kalek, Marcin published the artcile< Synthesis of Aryl Sulfides by Metal-Free Arylation of Thiols with Diaryliodonium Salts under Basic Conditions>, Electric Literature of 96-53-7, the main research area is aryl sulfide preparation DFT; thiol diaryliodonium salt arylation.

Metal-free arylation of thiols RSH (R = n-Bu, Bn, 2,3-dihydro-1,3-benzothiazol-2-yl, etc.) with diaryliodonium salts (Ar)2I+TfO-(Ar = 2,4,6-trimethylphenyl, 2-fluorophenyl, 4-nitrophenyl, etc.) have been developed. The application of a strong organic base enables the C-S bond formation under mild and exptl. simple conditions. The method allows for the synthesis of aryl sulfides R1SAr containing a broad range of aryl groups from an array of thiols, including aryl, heteroaryl, and alkyl ones. The mechanism of the reaction was studied by DFT calculations, demonstrating that it proceeds via the inner sphere pathway involving formation of an Ar2I(SR) intermediate, followed by reductive elimination.

European Journal of Organic Chemistry published new progress about Arylation. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sinenko, V. O.; Slivchuk, S. R.; Bal’on, Ya. G.; Brovarets, V. S. published the artcile< Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles>, Category: thiazole, the main research area is aldehyde reduction reaction; thiazole dialkyl dihydroxy preparation.

A general approach towards synthesis of 2,5-hydroxyalkyl-substituted 1,3-thiazole derivatives I (R = H, CH3, C6H5; R1 = H, CH3, C6H5) has been proposed. The method includes lithiation of 1,3-thiazole ring followed by the reaction of formed thiazole lithium derivatives with electrophiles.

Russian Journal of General Chemistry published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Rashmi, S. V.; Sandhya, N. C.; Raghava, B.; Kumara, M. N.; Mantelingu, K.; Rangappa, K. S. published the artcile< Trifluoroethanol as a metal-free, homogeneous, and recyclable medium for the efficient one-pot synthesis of dihydropyrimidones>, SDS of cas: 1003-32-3, the main research area is dihydropyrimidone preparation; aldehyde ketoester urea multicomponent condensation trifluoroethanol catalyst.

Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of β-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst.

Synthetic Communications published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, SDS of cas: 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

da Silva, Monize M.; Ribeiro, Gabriel H.; de Camargo, Mariana S.; Ferreira, Antonio G.; Ribeiro, Leandro; Barbosa, Marilia I. F.; Deflon, Victor M.; Castelli, Silvia; Desideri, Alessandro; Correa, Rodrigo S.; Ribeiro, Arthur B.; Nicolella, Heloiza D.; Ozelin, Saulo D.; Tavares, Denise C.; Batista, Alzir A. published the artcile< Ruthenium(II) Diphosphine Complexes with Mercapto Ligands That Inhibit Topoisomerase IB and Suppress Tumor Growth In Vivo>, HPLC of Formula: 96-53-7, the main research area is melanoma antitumor lung breast cancer hTopIB docking ruthenium complexes.

Ruthenium(II) complexes (Ru1-Ru5), with the general formula [Ru(N-S)(dppe)2]PF6, bearing two 1,2-bis(diphenylphosphino)ethane (dppe) ligands and a series of mercapto ligands (N-S), have been developed. The combination of these ligands in the complexes endowed hydrophobic species with high cytotoxic activity against five cancer cell lines. For the A549 (lung) and MDA-MB-231 (breast) cancer cell lines, the IC50 values of the complexes were 288- to 14-fold lower when compared to cisplatin. Furthermore, the complexes were selective for the A549 and MDA-MB-231 cancer cell lines compared to the MRC-5 nontumor cell line. The multitarget character of the complexes was investigated by using calf thymus DNA (CT DNA), human serum albumin, and human topoisomerase IB (hTopIB). The complexes potently inhibited hTopIB. In particular, complex [Ru(dmp)(dppe)2]PF6 (Ru3) (I), bearing the 4,6-diamino-2-mercaptopyrimidine (dmp) ligand, effectively inhibited hTopIB by acting on both the cleavage and religation steps of the catalytic cycle of this enzyme. Mol. docking showed that the Ru1-Ru5 complexes have binding affinity by active sites on the hTopI and hTopI-DNA, mainly via π-alkyl and alkyl hydrophobic interactions, as well as through hydrogen bonds. Complex Ru3 displayed significant antitumor activity against murine melanoma in mouse xenograph models, but this complex did not damage DNA, as revealed by Ames and micronucleus tests.

Inorganic Chemistry published new progress about Antitumor agents. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, HPLC of Formula: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tao, Zhi-Fu; Wang, Le; Stewart, Kent D.; Chen, Zehan; Gu, Wendy; Bui, Mai-Ha; Merta, Philip; Zhang, Haiying; Kovar, Peter; Johnson, Eric; Park, Chang; Judge, Russell; Rosenberg, Saul; Sowin, Thomas; Lin, Nan-Horng published the artcile< Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors>, COA of Formula: C4H3NOS, the main research area is macrocyclic diarylurea preparation checkpoint kinase inhibitor.

Based on the crystallog. anal. of a urea-checkpoint kinase 1 (Chk1) complex and mol. modeling, a class of macrocyclic Chk1 inhibitors were designed and their biol. activities were evaluated. An efficient synthetic methodol. for macrocyclic ureas was developed with Grubbs metathesis macrocyclization as the key step. The structure-activity relationship studies demonstrated that the macrocyclization retains full Chk1 inhibition activity and that the 4-position of the Ph ring can tolerate a wide variety of substituents. These Chk1 inhibitors exhibited excellent selectivity over a panel of more than 70 kinases. Some compounds, e.g., I, were identified as ideal Chk1 inhibitors, which showed little or no single-agent activity but significantly potentiate the cytotoxicities of the DNA-damaging antitumor agents doxorubicin and camptothecin. These Chk1 inhibitors abrogate the doxorubicin-induced G2 and camptothecin-induced S checkpoint arrests, confirming that their potent biol. activities are mechanism-based through Chk1 inhibition.

Journal of Medicinal Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, COA of Formula: C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Yin, Zhiping; Zhang, Zhuan; Soule, Jean-Francois; Dixneuf, Pierre H.; Wu, Xiao-Feng published the artcile< Iron-catalyzed carbonylative alkyl-acylation of heteroarenes>, Quality Control of 1003-32-3, the main research area is alkyl heteroaryl ketone preparation chemoselective; heteroarene carbon monoxide carbonylative alkyl acylation iron triflate.

Herein, an efficient carbonylative protocol for the introduction of an alkyl-acyl group into heteroarenes from cyclobutanone oximes is presented. In the presence of Fe(OTf)2 catalyst, proceeds via intermol. alkyl-acylation of different heteroarenes. A broad range of alkyl heteroaryl ketones are synthesized with excellent functional group tolerance with good chemoselectivity.

Journal of Catalysis published new progress about Acylation (alkyl-). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Quality Control of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica