Tag: M.W:100-200

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19759-66-1, Name is 2-Aminobenzothiazole-6-carbonitrile, molecular formula is C8H5N3S. In a Patent，once mentioned of 19759-66-1, COA of Formula: C8H5N3S

A disperse dye of the formula, STR1 wherein R1 is an alkyl group having 5 to 6 carbon atoms, R2 is an alkyl group having 5 to 6 carbon atoms, a cyano-ethyl group, R3 is a hydrogen atom or a lower alkyl, amino or phenyl group, and Y1 and Y2 represent independently a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a nitro group, a cyano group, a thiocyanate group or an alkylsulfonyl group, provided that both Y1 and Y2 are not hydrogen at the same time and Y1 is located at the 4- or 5-position, which is useful for dyeing hydrophobic fibers in brilliant red to violet shade with good fastnesses.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C8H5N3S, you can also check out more blogs about19759-66-1

Reference：
Thiazole | C3H2269NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 3364-80-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 3364-80-5, C4H3NOS. A document type is Article, introducing its new discovery.

Nucleoside-derived drugs play an important role in the treatment of cancer. Here, we present the synthesis and characterization of an intriguing series of N3 conjugated Re(CO)3 thymidine complexes. The complexes were characterized by NMR spectroscopy and mass spectrometry and their cytotoxicity was assessed against A549 cells. A similar dependence on the spacer length and the toxicity has been found for N3 functionalized complexes as recently reported for their C5? counterparts. A remarkable cytotoxic complex 22, carrying a dodecylene spacer at position N3 with a bis-quinoline metal chelate moiety, with an IC50 value of 3.4 ± 1.6 muM, has been identified. Addition of a 100-fold excess of thymidine did not statistically reduce the observed cytotoxicity of all complexes. Cellular uptake studies of complex 22 have been performed by fluorescent microscopy, showing that compound 22 was clearly internalized into A549 cells. Temperature dependent uptake studies, blocking experiments with thymidine, and endosomal co-localization suggest that uptake of 22 occurs via passive diffusion and endocytosis.

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Reference：
Thiazole | C3H9310NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 278183-10-1. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 278183-10-1, Name is Methyl 4-amino-5-thiazolecarboxylate. In a document type is Article, introducing its new discovery.

A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)imidazo<1,2-b>pyridazines (1) and 3-methoxy-2,6-diphenylimidazo<1,2-b>pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O-alkylation of the corresponding imidazo<1,2-b>pyridazin-3(5H-ones with diazoalkanes. 6-Chloro-3-methoxy-2-phenylimidazo<2,1-a>phthalazine was prepared similarly.

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Reference：
Thiazole | C3H8469NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 1759-28-0, An article , which mentions 1759-28-0, molecular formula is C6H7NS. The compound – 4-Methyl-5-vinylthiazole played an important role in people’s production and life.

The Neotropical aroid genus Xanthosoma (Caladieae, Araceae) embraces about 140 species of tuberous herbs whose night-blooming inflorescences emit strong, pleasant floral scents, presumably involved in the atttaction of pollinators. The number of studies on the floral scent chemistry of aroids, as well as on their role in pollinator attraction, has undergone a considerable increase in the last decade. In Xanthosoma, however, neither have never been properly assessed. In the present study, we provide an overview on the reproductive and pollination biology of Xanthosoma species and add new reports on the pollinators of some species. Furthermore, we investigate the floral scent chemistry of 13 species through dynamic headspace sample collection and analysis by gas chromatography coupled to mass spectrometry (GC?MS). A thorough literature survey and novel data from our own personal findings revealed that floral visitors are known for only 12 species of Xanthosoma, which represent less than 10% of its currently documented species diversity. Cyclocephaline scarabs (Melolonthidae, Cyclocephalini) were reported in inflorescences of 11 of the 12 species and are assumed to be the main pollinators associated with them. A total of 76 VOCs, mainly terpenes and benzenoids, were detected. Floral scent bouquets diverge considerably among analyzed species of Xanthosoma mainly due to the presence of unique prominent compounds that ensure originality of the blends rather than because of their quantitative complexity (number of constituents), as analyzed samples were typically dominated by few (2?4) VOCs that together accounted for >80% of the total relative scent discharge. A number of these dominant VOCs had already been isolated in other species of aroids and reported as effective attractants of cyclocephaline scarabs in field biossays, namely (Z)-jasmone, p-vinylanisole and dihydro-beta-ionone and we speculate that along with other dominant compounds they are directly involved in pollinator selection in Xanthosoma.

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Reference：
Thiazole | C3H5620NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 3364-80-5. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 3364-80-5, Name is Thiazole-4-carboxaldehyde

The present application relates to novel heteroaryl-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders

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Reference：
Thiazole | C3H9275NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 137-00-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 137-00-8, Name is 4-Methyl-5-thiazoleethanol

Recent studies applying Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) showed that the exometabolome of marine bacteria is composed of a surprisingly high molecular diversity. To shed more light on how this diversity is generated we examined the exometabolome of two model strains of the Roseobacter group, Phaeobacter inhibens and Dinoroseobacter shibae, grown on glutamate, glucose, acetate or succinate by FT-ICR-MS. We detected 2,767 and 3,354 molecular formulas in the exometabolome of each strain and 67 and 84 matched genome-predicted metabolites of P. inhibens and D. shibae, respectively. The annotated compounds include late precursors of biosynthetic pathways of vitamins B1, B2, B5, B6, B7, B12, amino acids, quorum sensing-related compounds, indole acetic acid and methyl-(indole-3-yl) acetic acid. Several formulas were also found in phytoplankton blooms. To shed more light on the effects of some of the precursors we supplemented two B1 prototrophic diatoms with the detected precursor of vitamin B1 HET (4-methyl-5-(beta-hydroxyethyl)thiazole) and HMP (4-amino-5-hydroxymethyl-2-methylpyrimidine) and found that their growth was stimulated. Our findings indicate that both strains and other bacteria excreting a similar wealth of metabolites may function as important helpers to auxotrophic and prototrophic marine microbes by supplying growth factors and biosynthetic precursors.

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Reference：
Thiazole | C3H5441NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 2942-13-4, An article , which mentions 2942-13-4, molecular formula is C8H7NOS. The compound – 6-Methoxybenzo[d]thiazole played an important role in people’s production and life.

The title compound was prepared in one step from commercially available 2-amino-6-methoxybenzothiazole by using the Sandmeyer cyanation reaction.The result enabled us to synthesize firefly luciferin effectively from this amino compound through three steps in 36percent overall yield.

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Reference：
Thiazole | C3H7137NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 348-40-3. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine

We describe the synthesis and photophysical properties of 11 substituted 5-(benzothiazol-2-yl)-2?-deoxyuridine derivatives and oligodeoxyribonucleotides (ODNs) containing 5-(5,6-dimethoxybenzothiazol-2-yl)- 2?-deoxyuridine (dbtU), which was the strongest fluorescent derivative among those prepared. The fluorescence properties of dbtU itself and ODNs containing dbtU show the same tendency of being weaker in both neutral and acidic solution and stronger in basic solution. The ODNs (15mer) containing 16 combinations of 5?-XbtU-3? and 5?-btUY-3?, where X, Y = A, T, G, or C, were synthesized, and their fluorescence intensity and quantum yield in basic solution were compared. On average, only the ODN with the 5?-G btU-3? sequence shows a 7.9-fold lower fluorescence intensity than the other sequences. Ab initio calculations of 5?-G btU-3? and 5?-btUG-3? as models under basic conditions suggest that the lower fluorescence of the ODN containing the 5?-GbtU-3? sequence is caused by a wider overlap between stacked guanine (Gua) and btUra than that of the 5?- btUG-3? sequence and that the HOMO is delocalized not only on btUra but also on Gua.

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Reference：
Thiazole | C3H10343NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 121-66-4. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 121-66-4, Name is 5-Nitrothiazol-2-amine. In a document type is Article, introducing its new discovery.

Efficient procedure was developed for 3-hetaryl-1,5,3-dithiazepanes and 3-hetaryl-1,5,3-dithiazocanes preparation from hetarylamines, N,N,N?,N?-tetramethylmethanediamine, and alpha,omega- alkanedithiols (ethane-1,2-dithiol, propane-1,3-dithiol), and also by the reaction of the latter with N,N-bis(methoxymethyl)hetarylamines in the presence of catalytic quantities of transition metals salts.

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Reference：
Thiazole | C3H9488NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 1603-91-4. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1603-91-4, Name is 4-Methylthiazol-2-amine

Based on the multi-target strategy to treat type 2 diabetes mellitus (T2DM), glucokinase/peroxisome proliferator-activated receptor gamma (GK/PPARgamma) dual-target molecules were constructed by the rational combination of pharmacophores from known GK activators and PPARgamma agonists. A series of dual-target agents were designed and synthesized, and their capacities to induce GK and PPARgamma transcriptional activity were evaluated. Three of these compounds showed particularly high potency toward GK, moderate activity toward PPARgamma, and their structure-activity relationships were preliminarily analyzed. The putative binding modes of one of the most promising compounds were also explored by molecular docking simulations with GK and PPARgamma. Two birds, one stone: GK/PPARgamma dual-target ligands were constructed by rational combination of pharmacophores from known GK activators and PPARgamma agonists. Their ability to induce GK and PPARgamma transcriptional activity were evaluated, and the putative binding modes of one of the most promising compounds were also explored by molecular docking simulations with GK and PPARgamma.

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Reference：
Thiazole | C3H9844NS – PubChem,
Thiazole | chemical compound | Britannica