Tag: M.W:100-200

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Patent£¬once mentioned of 348-40-3, SDS of cas: 348-40-3

The present invention relates to substituted pyrazolo-quinazoline derivatives which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune- related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

The present invention relates to substituted pyrazolo-quinazoline derivatives which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune- related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 348-40-3, you can also check out more blogs about348-40-3

Reference£º
Thiazole | C3H10377NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.41731-23-1, Name is 2-Bromo-5-methylthiazole, molecular formula is C4H4BrNS. In a Patent£¬once mentioned of 41731-23-1, Formula: C4H4BrNS

Disclosed are immune-modulators of formula (I), the preparation method thereof, a pharmaceutical composition containing the immune-modulators, and the use of the pharmaceutical composition as a drug, especially as an immune-modulating drug. The compound can be used in immune disorders and immune suppression, and can be used in treating hypo-immunity, rejection after organ transplantation and auto-immune disease.

Disclosed are immune-modulators of formula (I), the preparation method thereof, a pharmaceutical composition containing the immune-modulators, and the use of the pharmaceutical composition as a drug, especially as an immune-modulating drug. The compound can be used in immune disorders and immune suppression, and can be used in treating hypo-immunity, rejection after organ transplantation and auto-immune disease.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C4H4BrNS, you can also check out more blogs about41731-23-1

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Thiazole | C3H2601NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2289-75-0, Name is 4,5-Dimethylthiazol-2-amine, molecular formula is C5H8N2S. In a Patent£¬once mentioned of 2289-75-0, Safety of 4,5-Dimethylthiazol-2-amine

Compounds of the formula STR1 wherein R1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R2 is hydrogen or alkyl of 1 to 3 carbon atoms; and R3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic heterocycle of 2 to 9 carbon atoms and 1 to 2 nitrogen atoms and/or an oxygen or a sulfur atom, where each of said aromatic substituents may in turn be substituted with one or two alkyls of 1 to 6 carbon atoms, halogen, hydroxyl, trifluoromethyl, halophenyl or alkoxy of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as analgesics, antipyretics, antithrombotic and antiphlogistics.

Compounds of the formula STR1 wherein R1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R2 is hydrogen or alkyl of 1 to 3 carbon atoms; and R3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic heterocycle of 2 to 9 carbon atoms and 1 to 2 nitrogen atoms and/or an oxygen or a sulfur atom, where each of said aromatic substituents may in turn be substituted with one or two alkyls of 1 to 6 carbon atoms, halogen, hydroxyl, trifluoromethyl, halophenyl or alkoxy of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as analgesics, antipyretics, antithrombotic and antiphlogistics.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2289-75-0 is helpful to your research., Safety of 4,5-Dimethylthiazol-2-amine

Reference£º
Thiazole | C3H5012NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 3048-45-1, Name is 4-Chlorobenzo[d]thiazole, molecular formula is C7H4ClNS. In a Article£¬once mentioned of 3048-45-1, Product Details of 3048-45-1

The palladium-catalyzed, copper-promoted cross-dehydrogenative-coupling (CDC) of electron-deficient thiazoles with azine N-oxides through dual C-H activations was developed. It was found that copper(II) pivalate was an efficient dual-function reagent for the oxidative cross-coupling reactions, playing the roles of both an oxidant and a C-H bond activation promoter. This methodology provides a simple way to construct 2-thiazolyl pyridine moiety.

The palladium-catalyzed, copper-promoted cross-dehydrogenative-coupling (CDC) of electron-deficient thiazoles with azine N-oxides through dual C-H activations was developed. It was found that copper(II) pivalate was an efficient dual-function reagent for the oxidative cross-coupling reactions, playing the roles of both an oxidant and a C-H bond activation promoter. This methodology provides a simple way to construct 2-thiazolyl pyridine moiety.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Product Details of 3048-45-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3048-45-1, in my other articles.

Reference£º
Thiazole | C3H5233NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10200-59-6, Name is 2-Thiazolecarboxaldehyde, molecular formula is C4H3NOS. In a Article£¬once mentioned of 10200-59-6, category: thiazole

Alkynylation of aldehydes with alkynyl(aryl)iodonium salts catalyzed by an N-heterocyclic carbene (NHC) has been developed. The application of the organocatalyst and the hypervalent iodine group transfer reagent allowed for metal-free C-H functionalization and C-C bond formation. The reaction proceeds under mild conditions, at -40 C and in the presence of an amine base, providing access to an array of heteroaryl-propargyl ketones containing various substituents in good to excellent yields. The mechanism of the reaction was investigated by means of both experiments and density functional theory calculations. 13C-labeling and computations determined that the key alkynyl transfer step occurs via an unusual direct substitution at an acetylenic carbon, wherein an iodine-based leaving group is exchanged by a Breslow intermediate nucleophile. Moreover, kinetic studies revealed that the turnover-limiting step of the catalytic cycle is the generation of the Breslow intermediate, whereas the subsequent C-C bond formation is a fast process. These results are fully reproduced and rationalized by the calculated full free energy profile of the reaction, showing that the largest energy span is located between the protonated form of NHC catalyst and the transition state for the carbene attack on the aldehyde substrate.

Alkynylation of aldehydes with alkynyl(aryl)iodonium salts catalyzed by an N-heterocyclic carbene (NHC) has been developed. The application of the organocatalyst and the hypervalent iodine group transfer reagent allowed for metal-free C-H functionalization and C-C bond formation. The reaction proceeds under mild conditions, at -40 C and in the presence of an amine base, providing access to an array of heteroaryl-propargyl ketones containing various substituents in good to excellent yields. The mechanism of the reaction was investigated by means of both experiments and density functional theory calculations. 13C-labeling and computations determined that the key alkynyl transfer step occurs via an unusual direct substitution at an acetylenic carbon, wherein an iodine-based leaving group is exchanged by a Breslow intermediate nucleophile. Moreover, kinetic studies revealed that the turnover-limiting step of the catalytic cycle is the generation of the Breslow intermediate, whereas the subsequent C-C bond formation is a fast process. These results are fully reproduced and rationalized by the calculated full free energy profile of the reaction, showing that the largest energy span is located between the protonated form of NHC catalyst and the transition state for the carbene attack on the aldehyde substrate.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.category: thiazole, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10200-59-6, in my other articles.

Reference£º
Thiazole | C3H4423NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 1003-60-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 1003-60-7, C5H5NOS. A document type is Patent, introducing its new discovery.

The invention concerns novel compounds of the formula I STR1 wherein: A, B and D are selected from CH and N; E is selected from oxygen and sulfur; X are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, phenyl, substituted phenyl, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof; R1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation; R2 is selected from alkyl substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl; R3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl; R4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl; and n is 0 or an integer chosen from 1 and 2. The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

The invention concerns novel compounds of the formula I STR1 wherein: A, B and D are selected from CH and N; E is selected from oxygen and sulfur; X are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, phenyl, substituted phenyl, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof; R1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation; R2 is selected from alkyl substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl; R3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl; R4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl; and n is 0 or an integer chosen from 1 and 2. The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

If you are hungry for even more, make sure to check my other article about 1003-60-7. Synthetic Route of 1003-60-7

Reference£º
Thiazole | C3H3875NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 121-66-4, Name is 5-Nitrothiazol-2-amine, Quality Control of: 5-Nitrothiazol-2-amine.

The invention “anti-CVA16 type of HFMD compound and its synthesis method”, which belongs to the technical field of drug synthesis, the compound of the chemical formula as shown in I, anti-virus experimental display has good anti-CVA16-type virus activity, can be used as anti-disease virus candidate medicine. (by machine translation)

The invention “anti-CVA16 type of HFMD compound and its synthesis method”, which belongs to the technical field of drug synthesis, the compound of the chemical formula as shown in I, anti-virus experimental display has good anti-CVA16-type virus activity, can be used as anti-disease virus candidate medicine. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 5-Nitrothiazol-2-amine. In my other articles, you can also check out more blogs about 121-66-4

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Thiazole | C3H9425NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article£¬once mentioned of 19952-47-7, Product Details of 19952-47-7

A series of (<*>fifty) N-substituted 3,6-epoxyhexahydrophthalic acid amides have been prepared by the reaction of exo-cis-7-oxabicyclo<2.2.1>heptane-2,3-dicarboxylic anhydride with primary amines in benzene.Many of the compounds show anticonvulsant activity against electroshock, metrazol, strychnine and picrotoxin induced convulsions.Several compounds are found to be superior to ethosuximide and sodium valproate in anti-electroshock and antimetrazol test systems.

A series of (<*>fifty) N-substituted 3,6-epoxyhexahydrophthalic acid amides have been prepared by the reaction of exo-cis-7-oxabicyclo<2.2.1>heptane-2,3-dicarboxylic anhydride with primary amines in benzene.Many of the compounds show anticonvulsant activity against electroshock, metrazol, strychnine and picrotoxin induced convulsions.Several compounds are found to be superior to ethosuximide and sodium valproate in anti-electroshock and antimetrazol test systems.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 19952-47-7, you can also check out more blogs about19952-47-7

Reference£º
Thiazole | C3H10068NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 10200-59-6, Name is 2-Thiazolecarboxaldehyde, Computed Properties of C4H3NOS.

Metallafuran complexes with a fused five-membered phosphonium ring were synthesized from reactions between terminal ynones HC?C(C=O)R and cis-[Ru/Os(dppm)2Cl2] (dppm=1,1-bis(diphenylphosphino)methane). A metal?vinylidene-involving pathway was found to be an energetically feasible formation mechanism for these complexes. These phosphonium-containing metallafurans, like many phosphonium-functionalized drugs, have the ability to induce mitochondrial dysfunction. They also exhibit stronger cytotoxicity against several human cancer cell lines in comparison with their metal precursors and the classic anticancer drug cisplatin. Overall, this work provides structural and mechanistic insights for the rational design of functional metallacycles via activation of alkynes by RuII and OsII centers.

Metallafuran complexes with a fused five-membered phosphonium ring were synthesized from reactions between terminal ynones HC?C(C=O)R and cis-[Ru/Os(dppm)2Cl2] (dppm=1,1-bis(diphenylphosphino)methane). A metal?vinylidene-involving pathway was found to be an energetically feasible formation mechanism for these complexes. These phosphonium-containing metallafurans, like many phosphonium-functionalized drugs, have the ability to induce mitochondrial dysfunction. They also exhibit stronger cytotoxicity against several human cancer cell lines in comparison with their metal precursors and the classic anticancer drug cisplatin. Overall, this work provides structural and mechanistic insights for the rational design of functional metallacycles via activation of alkynes by RuII and OsII centers.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C4H3NOS. In my other articles, you can also check out more blogs about 10200-59-6

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Thiazole | C3H4317NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.81449-93-6, Name is Ethyl 2-chlorothiazole-5-carboxylate, molecular formula is C6H6ClNO2S. In a Article£¬once mentioned of 81449-93-6, category: thiazole

The photochemical reaction between ethyl 2-chlorothiazole5-carboxylate and benzene gave no product. In contrast, the reaction with ethyl 2-iodothiazole-5-carboxylate gave ethyl 3-phenylisothiazole-4-carboxylate. The same behaviour was observed if the reaction was performed in the presence of furan, thiophene and 2-bromothiophene. The products thus obtained were studied for their photophysical properties and it was found that the observed absorptions [lambdamax=257 nm (epsilon = 7000 M-1 cm -1) for ethyl 3-phenylisothiazole-4-carboxylate, 278 nm (epsilon = 7000 M-1 cm-1) for ethyl 3-(2-furyl)isothiazole- 4carboxylate, 269 and 285 nm (epsilon = 7500M-1Cm-1) for ethyl 3(2-thienyl)isothiazole-4-carboxylate] are mainly due to pi ? pi* transitions from the HOMO to the LUMO+1 orbital. The tested compounds showed fluorescence [lambdaem = 350-400 (lambdaexc = 300 nm), 360 and 410 nm (lambdaexc = 320 nm), 412 nm (lambdaexc = 340 nm) for ethyl 3-phenylisothiazole-4- carboxylate, 397 and 460 nm (lambdaexc = 300 nm), 381, 394 and 460 nm (lambdaexc = 320 nm), 381, 398 and 466 nm (lambda exc, = 340 nm) for ethyl 3-(2-furyl)isothiazole-4-carboxylate, 372, 377 and 414 nm (lambdaexc = 300, 320 and 340 nm respectively) for ethyl 3-(2-thienyl)isothiazole-4carboxylate], possibly due to dual emission from different excited states. The use of the compound obtained as a sensitizer in the photo-oxidation of trans-alpha,alpha’-dimethylstilbene showed that all the new compounds are singlet-oxygen sensitizers.

The photochemical reaction between ethyl 2-chlorothiazole5-carboxylate and benzene gave no product. In contrast, the reaction with ethyl 2-iodothiazole-5-carboxylate gave ethyl 3-phenylisothiazole-4-carboxylate. The same behaviour was observed if the reaction was performed in the presence of furan, thiophene and 2-bromothiophene. The products thus obtained were studied for their photophysical properties and it was found that the observed absorptions [lambdamax=257 nm (epsilon = 7000 M-1 cm -1) for ethyl 3-phenylisothiazole-4-carboxylate, 278 nm (epsilon = 7000 M-1 cm-1) for ethyl 3-(2-furyl)isothiazole- 4carboxylate, 269 and 285 nm (epsilon = 7500M-1Cm-1) for ethyl 3(2-thienyl)isothiazole-4-carboxylate] are mainly due to pi ? pi* transitions from the HOMO to the LUMO+1 orbital. The tested compounds showed fluorescence [lambdaem = 350-400 (lambdaexc = 300 nm), 360 and 410 nm (lambdaexc = 320 nm), 412 nm (lambdaexc = 340 nm) for ethyl 3-phenylisothiazole-4- carboxylate, 397 and 460 nm (lambdaexc = 300 nm), 381, 394 and 460 nm (lambdaexc = 320 nm), 381, 398 and 466 nm (lambda exc, = 340 nm) for ethyl 3-(2-furyl)isothiazole-4-carboxylate, 372, 377 and 414 nm (lambdaexc = 300, 320 and 340 nm respectively) for ethyl 3-(2-thienyl)isothiazole-4carboxylate], possibly due to dual emission from different excited states. The use of the compound obtained as a sensitizer in the photo-oxidation of trans-alpha,alpha’-dimethylstilbene showed that all the new compounds are singlet-oxygen sensitizers.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 81449-93-6 is helpful to your research., category: thiazole

Reference£º
Thiazole | C3H8116NS – PubChem,
Thiazole | chemical compound | Britannica