Tag: M.W:100-200

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of substituted o-phenyldiamine (1.0 equiv), thiazole-4-aldehyde or pyridine-2-aldehyde (1.0 equiv) with sodium pyrosulfite in DMF was stirred at 120¡ã C overnight. On completion of the reaction monitored by TLC, the solvent was evaporated and the residue was purified by silica gel chromatography by DCM/MeOH system to afford the final product. If necessary, the crudeproduct could be recrystallized in DCM or dichloroethane to afford pure sample., 3364-80-5

As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.

Reference£º
Article; Zhang, Chao; Zhong, Bo; Yang, Simin; Pan, Liangkun; Yu, Siwang; Li, Zhongjun; Li, Shuchun; Su, Bin; Meng, Xiangbao; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3774 – 3780;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6633-61-0,Methyl 2-aminothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,6633-61-0

General procedure: A solution of the selected heterocyclic starting material (1.00 mmol) in THF (10 mL) and a solutionof isopentyl nitrite (141 mg, 1.20 mmol) in THF (10 mL) were both pumped at a flow rate of 0.25 mLmin1 with a Vapourtech ?Easy MedChem V3? system, meeting at a PTFE T-piece and the outputflowing through a 10.0 mL coil reactor maintained at 120 C, giving a residence time of 20 min.The pressure of the system was maintained at 7 bar with a back-pressure regulator. For compoundswhere an isolated yield was reported: the output mixture was concentrated under reduced pressureto give an oil (or powder). The oil (or powder) was purified using column chromatography withvarious mixtures of ethyl acetate and hexane as the eluent, or by recrystallisation using methanol, togive isolated compounds that showed no impurities by NMR spectroscopy. For compounds where aconversion was reported (due to volatility of products), the output mixture was carefully concentratedunder a reduced pressure of 100 mbar for 10 min and the conversion was calculated by integration ofproduct peaks to a quantified internal standard (nitrobenzene).

As the paragraph descriping shows that 6633-61-0 is playing an increasingly important role.

Reference£º
Article; Roeder, Liesa; Nicholls, Alexander J.; Baxendale, Ian R.; Molecules; vol. 24; 10; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101012-12-8,2-Chloro-1,3-thiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

2-Ch[oro-1,3-thiazo[e-4-carboxy[ic acid [CAS RN: 5198-87-8] (430 mg,2.55 mmo[, 1.0 eq) in 17 mL ethyl. acetate was treated with T3P solution [50 % in ethyl acetate] (3.80 mL, 6.37 mmol, 2.5 eq) and with acetohydrazide [CASRN: 1068-57-1] (189 mg, 2.55 mmol, 1.0 eq). The resulting solution was stirred at 80 C overnight. The reaction mixture was hydrolysed with ice-water and extracted with ethyl acetate (3x). The combined organic phases were washedwith brine. The phases were separated by the use of a Whatman filter. The volatile components of the resulting organic phase were removed in vacuo and the crude material contained 350 mg (50% yield of theory) of the title compound in 80% purity (UPLC area-%), which were used without further purification.UPLC-MS (Method 2): R = 0.90 mm; MS (EI0): m/z = 202 [M+H].1H-NMR (400 MHz, DMSO-d6): oe [ppm] = 2.41 (5, 3H), 8.71 (5, 1H).

101012-12-8, As the paragraph descriping shows that 101012-12-8 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1477-42-5, 4-Methylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The reaction carried out with 4-chloro-4-fluorobutyrophenone 7 (0.5ml, 3.04mmol) with imidazole 28 (0.21g, 3.04mmol) and K2CO3 (1g, 7.23mmol) in DMSO at 140C till the completion of reaction (TLC). After the completion of reaction, the workup was done with ethylacetate and water and then the organic layer was separated, dried over anhydrous Na2SO4 and evaporated under reduced pressure. The latter was purified by silica gel (60-120 mesh) column chromatography using ethylacetate: hexane (1:1) as eluent to give the title compound in 80% yield (0.51g), 1477-42-5

The synthetic route of 1477-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Singh, Kartikey; Sona, Chandan; Ojha, Vikash; Singh, Maninder; Mishra, Ankita; Kumar, Ajeet; Siddiqi, Mohammad Imran; Tripathi, Rama P.; Yadav, Prem N.; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 499 – 516;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

40283-46-3, 2-Aminothiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 14: 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic acid BocHN [0111] A mixture of 2-aminothiazole-5-carboxylic acid (2.2 kg, 15.33 mol), aqueous 2 M NaOH (0.674 kg in 8.39 L of DI water), DI water (17.68 L), and THF (17.68 L) was cooled to about 0C. A solution of Boc-anhydride (4.02 kg, 1.20 equiv) in THF (2.21 L) was added to the mixture while maintaining an internal temperature below 5C. When the addition was complete, the reaction mixture was warmed to an internal temperature of 25C and was stirred for 24 hours. The reaction mixture was cooled to about 0C and diluted with DI water (22.1 L). While maintaining an internal temperature below 5C, the pH of the mixture was adjusted to 4.9 by slowly adding acetic acid (5.30 L). After 1 hour a precipitate formed, which was collected by filtration, and rinsed successively with DI water (6.63 L) and MTBE (4.42 L). The filter cake was held under nitrogen for 1 hour and then dried under reduced pressure at 25C to afford the title compound (5.14 kg).

40283-46-3, The synthetic route of 40283-46-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATTHEWS, Christopher; O’BRYAN, Colin; PROVENCAL, David Paul; WO2012/51450; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-66-0,2,5-Dimethylthiazole,as a common compound, the synthetic route is as follows.

To a solution of 2, 5-dimethylthiazole (0.730 g, 5.10 mmol) in benzene (80 mL). add N-bromosuccinimide (0.908 g, 5.10 mmol) and a catalytic amount of benzoyl peroxide. Heat the solution at reflux for 2 hours and stir overnight at room temperature. Cool the mixture, dilute with diethyl ether, wash with saturated NA2*S03 (75 mL), followed by saturated sodium hydrogencarbonate (75 mL), dry (NA2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 100% diethyl ether to afford 390 mg of the title compound. IN NMR (CDCL3) 67. 39 (s, 1H), 4.70 (s, 2H), 2.48 (s, 3H)., 4175-66-0

The synthetic route of 4175-66-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.121-66-4,5-Nitrothiazol-2-amine,as a common compound, the synthetic route is as follows.,121-66-4

Example 1 Preparation of N-(5-Nitro-thiazol-2-yl)-2-pyridin-3-yl-acetamide (compound 13) To a solution of 3-Pyridylacetic acid hydrochloride (2.076 g, 12 mmol) in anhydrous THF, 1.5 equivalents of CDI (18 mmol, 2.916 g) in anhydrous THF and 1 equivalent of NEt3 (1.66 mL) are added. The resulting mixture is allowed to stir at room temperature for 4 hours. Then, 2-amino-5-nitro-thiazol (12 mmol, 1.740 g) in THF is added to the reaction mixture and this is stirred at room temperature for 10 h. When the reaction is completed, the solvent is evaporated and the resulting brown crude is dissolved in CH2Cl2 and water. This mixture produces a yellow precipitate, which is filtered and washed with water to obtain the desired compound as a yellow solid (2.300 g, yield: 73 %, 265 M+). 1H-NMR (DMSO): 3.95 (s, 2H); 7.38 (dd, 1H); 7.74 (d, 1H); 8.50 (d, 1H); 8.52 (s, 1H); 8.63 (s, 1H) 13C-NMR (DMSO): 38.52; 123.4; 129.7; 137.1; 141.7; 142.6; 148.1; 150.3; 161.8; 170.7

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Neuropharma, S.A.; EP1849785; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14542-16-6, 4-Methylthiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-methylthiazole-2-carboxylic acid (50.0 mg, 0.349 mmol) and CDI (84.9 mg,0.524 mmol) in THF (5.0 mL) was stirred at room temperature for 1 h, 2-amino-6-methylpyridine (37.7 mg, 0.349 mmol) was added. The mixture was stirred at room temperature for 2 h. The subsequent mixture was concentrated under reduced pressure and extracted with H2O/ethyl acetate. The combined organic layer was dried over Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 10:1) to afford the title compound 6ae (55 mg, 57 %) as white solid; 1H-NMR (400MHz, CDCl3) delta 9.61(s, 1H), 8.12 (d, J = 8 Hz, 1H), 7.63(t, J = 8 Hz, 1H), 7.18 (d, J = 0.8, 1H), 6.93 (d, J = 7.2, 1H), 2.49 (d, J = 1.2, 1H). 13C-NMR (100MHz, CDCl3) delta 162.0, 157.7, 157.2, 154.4, 150.0, 138.7,120.4, 119.6, 110.9, 24.1, 17.0. LC/MS (ESI-) 234.1 (M+H)+., 14542-16-6

The synthetic route of 14542-16-6 has been constantly updated, and we look forward to future research findings.

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Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4175-76-2,4175-76-2, 2,4-Dichlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,4-Dichlorothiazole (10 g, 64.9 mmol) was dissolved in acetic acid (50.0 ml) and heated to 60 C. Bromine (15.05 ml, 292 mmol) was added dropwise and the reaction mixture then stirred at 90 C. for 5.5 hours. The reaction was cooled to room temperature and made basic by slow addition of solid sodium carbonate, then diluted with water (100 mL) and extracted with Et2O (3*150 ml). The combined organic extracts were washed with sat.aq. sodium thiosulfate (50 ml) dried over sodium sulfate evaporated under reduced pressure to afford the title compound as a pale yellow oil. LC-MS Rt 1.43 min [M+H]+ 275.9/277.9/279.9/281.9 (Method 2minLowpHv03)

The synthetic route of 4175-76-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; BLOOMFIELD, Graham Charles; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPERD, Jon; WRIGHT, Paul; US2014/171412; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

20949-84-2, 4-Formyl-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 51 6-FLUORO-2-[2-(2-METHYL-THIAZOL-4-YL)-VINYL]-3-(2-METHYL-PHENYL)-3H-QUINAZOLIN-4-ONE Anhydrous zinc chloride (0.136 g, 1.0 mmol) was fused with a nitrogen purge in a round bottom flask with an open flame. The reaction vessel was allowed to return to ambient temperature, then dioxane (10 mL) was added. To this mixture was added 6-fluoro-2-methyl-3-(2-methyl-phenyl)-3H-quinazolin-4-one (0.1 34 g, 0.5 mmol), acetic anhydride (0.141 mL, 1.5 mmol), and 2-methylthiazole-4-carboxaldehyde (0.191 g, 1.5 mmol). The reaction was refluxed 3.5 hours, at which time the reaction was allowed to cool to ambient temperature. Once the reaction had cooled to ambient temperature it was diluted with water. The resulting mixture was repeatedly extracted with chloroform. The chloroform extracts were combined and the resulting chloroform layer was washed with water and brine, dried over sodium sulfate and concentrated to leave a dark residue. This residue was triturated with ether, filtered and dried to afford 0.04 g (21%) of 6-fluoro-2-[2-(2-methyl-thiazol-4-yl)-vinyl]-3-(2-methyl-phenyl)-3H-quinazolin-4-one as a tan solid. Melting point: 211-212 C.; NMR delta 7.91 (dd, J=3, 8.3 Hz, 1 H), 7.87 (d, J=15 Hz, 1 H), 7.75 (dd, J=5, 9 Hz, 1 H), 7.49 (dt, J=3, 9 Hz, 1 H), 7.42 (sym m, 3 H), 6.61 (d, J=15 Hz, 1 H), 2.60 (s, 3 H), 2.09 (s, 3 H)., 20949-84-2

20949-84-2 4-Formyl-2-methylthiazole 2763191, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US6306864; (2001); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica