Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-40-3,6-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

6-Fluoro-2-hydrazinobenzothiazole (2). Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

348-40-3, The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 334: Methyl 2-(3-(4-(6-fluorobenzo[d]thiazol-2-yloxy)phenyl)isoxazole-5- carboxamido)-3-methylbutanoate; To methyl 2-(3-(4-hydroxyphenyl)isoxazole-5-carboxamido)-3-methylbutanoate (200 mg) in N,N’ -Dimethyl formamide (4 ml), cesium carbonate (245 mg) was added and stirred for 15 -20 minutes. To this 2-chloro-6-fluorobenzo[d]thiazole (141 mg) was added and the reaction mixture was stirred at RT for 18 hours. Solvent was evaporated to obtain pale brown solid, which was purified by column chromatography (silica gel, EtOAc – CHCI3) to obtain off white solid, which was crystallized using DCM- Petroleum ether to obtain the title compound as white solid. Yield: 240 mg (81 %); MS (ES+): m/z 470 (M+l); 1HNMR (DMSOd6,300MHz): delta 9.27 (d, IH), 8.08 (d, 2H), 7.93 (dd, IH), 7.8 (s, IH), 7.74 (dd, IH), 7.67 (d, 2H),7.31 (m, IH), 4.33 (m, IH), 3.69 (s, 3H), 2.23 (m, IH), 0.98 (d, 6H)., 399-74-6

The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMAL LIFE SCIENCES LIMITED; GANGOPADHYAY, Ashok Kumar; KADAM, Kishorkumar, Shivajirao; JADHAV, Ravindra, Dnyandev; MISTRY, Hitesh; SHARMA, Rajiv; WO2010/23609; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.121-66-4,5-Nitrothiazol-2-amine,as a common compound, the synthetic route is as follows.

N- (5-Nitro-1, 3-thiazol-2-yl) pentanamide To a solution of 2-amino-5-nitrothiazole (205 mg, 1.41 mmol) and triethylamine (271 muL, 2.11 mmol) in methylene chloride (25 mL) was added dropwise n-valeroylchloride (180 pL, 1.48 mmol). The reaction solution was stirred over night and washed with a saturated sodium bicarbonate solution. The layers were separated and the organic layer was dried with sodium sulfate, filtered and concentrated. The crude product was purified on a silica gel column using hexane/ethyl acetate (4: 1) as the eluent to give 130 mg (40% yield) of the title compound as a light yellow solid: mp 155-156 C ; IH NMR (CDC13, 300 MHz) 8 11.2 (br s, 1 H), 8.29 (s, 1 H), 2. 59 (t, J= 7 Hz, 2 H), 1.84-1. 74 (m, 2 H), 1. 51-1. 39 (m, 2 H), 0. 98 (t, J= 7 Hz, 3 H) ; 13C NMR (CDC13, 75 MHz) 8 171. 67,162. 02,143. 46, 139. 46, 35.98, 26.38, 22.24, 13.67 ; EIMS (70 eV) m/z (relative intensity) 229 (M+, 34), 85 (100), 57 (24)., 121-66-4

121-66-4 5-Nitrothiazol-2-amine 8486, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2003/89419; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.21 2-(3-(4-Methoxyphenyl)propanoyl)benzo[d]isothiazol-3(2H)-one (25) Compound 25 was prepared through 3-(4-methoxyphenyl)propionic acid, obtained a white solid in 94% yield. Mp 110.8-112.1 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 8.0 Hz, 1H), 7.20 (d, J = 8.4 Hz, 2H), 6.86 (d, J = 8.4 Hz, 2H), 3.72 (s, 3H), 3.36 (t, J = 7.6 Hz, 2H), 2.90 (t, J = 7.6 Hz, 2H). 13C NMR (101 MHz, DMSO-d6) delta 172.7, 163.5, 158.1, 141.3, 135.0, 132.9, 129.8, 127.4, 126.6, 125.7, 122.5, 114.2, 55.4, 39.4, 29.2. IR (KBr, cm-1): 1690, 1671. HRMS-ESI (m/z) calcd for C17H15NO3S [M+H+] 314.0851, found 314.0836.

2634-33-5, As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ketone (20 mmol) (2-acetylpyridine, 2-acetylthiazole or 2-acetylpyrazine)was added to a solution of aldehyde (10 mmol) (4-methoxybenzaldehyde,4-methoxy-1-naphthaldehyde or 6-methoxy-2-naphthaldehyde) in EtOH (75 mL). KOH (1.54 g, 27.5 mmol) and NH3(aq)(35 mL) were then added. The solution was stirred at room temp. for 24 h. The solid was collected by filtration and washed with H2O. Recrystallization from ethanol (L1,L4, L7) or toluene (L2, L3, L5, L6, L8,L9) afforded a crystalline solid.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of cyclohexyl-2-(phenylimino)-4-thiazolidineione,3-methyl-2-(phenylimino) thiazolidine-4-one, thiazolidine-2,4-dione, 3-methyl thiazolidine-2,4-dione or imidazolidine-2,4-dione (1.0 equiv) in absolute ethanol (15 mL) was added theappropriate 2,5-dimethyl-1-aryl -3-formylpyrrole (1.1 equiv),piperidine (1.2 equiv) and 3 molecular sieves. The mixture washeated to reflux at 90 C for 8e10 h, cooled, filtered and concentratedin vacuo. The residue was purified by column chromatographyon a silica gel column (ethylacetate/hexane ordichloromethane/hexane) and in some cases recrystallized frommethanol to give 20e54 as generally yellowish solids.

556-90-1, 556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Mital, Alka; Murugesan, Dinakaran; Kaiser, Marcel; Yeates, Clive; Gilbert, Ian H.; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 530 – 538;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14527-41-4, 5-Thiazolecarboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 3: Step a N-Methoxy-N-methylthiazole-5-carboxamide Triethylamine (2.77 mL, 19.9 mmol) was added slowly to a mixture of commercially available thiazole-5-carboxylic acid (1.03 g, 7.98 mmol), N,O-dimethylhydroxylamine hydrochloride (0.778 g, 7.98 mmol), and EDCI (1.83 g, 9.57 mmol) in CH2Cl2 (10 mL). The mixture was stirred at room temperature for 72 hours then quenched with saturated aqueous NaHCO3. Water (50 mL) was added followed by additional CH2Cl2. The mixture was stirred for 10 minutes and layers were separated. The CH2Cl2 layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure and the residual oil was chromatographed (CH2Cl2/EtOAc) to provide the title compound as a white solid., 14527-41-4

14527-41-4 5-Thiazolecarboxylic acid 84494, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; LEONARD, KRISTI A.; BARBAY, KENT; EDWARDS, JAMES P.; KREUTTER, KEVIN D.; KUMMER, DAVID A.; MAHAROOF, UMAR; NISHIMURA, RACHEL; URBANSKI, MAUD; VENKATESAN, HARIHARAN; WANG, AIHUA; WOLIN, RONALD L.; WOODS, CRAIG R.; FOURIE, ANNE; XUE, XIAOHUA; US2014/107096; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

0.15 mmol6-(2-chloropyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole,0.30 mmol 4-cyclopropyl-2-aminothiazole,0.025 mmol of tris(dibenzylideneacetone) dipalladium,0.028 mmol 2-dicyclohexylphosphor-2′,6′-diisopropoxy-1,1′-biphenyl,Mix 0.5 mmol cesium carbonate and 80 mL 1,4-dioxane.Put it on a vacuum pump for 10 minutes.Remove the water in the reaction material,In an argon atmosphere,110 ¡ãC reaction overnight;After the reaction is completed, naturally cool to room temperature.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.Dry the resulting organic layer under reduced pressureThen column chromatography,N-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)pyrimidin-2-amine is obtained;0.5mmolN-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)Pyrimidin-2-amine,Mix 5 mL of ethanol with 0.5mL of hydrochloric acid 1,4-dioxane solution.70 ¡ã C reaction 2h;After the reaction is complete, the resulting material is adjusted to pH 8 with saturated sodium bicarbonate solution.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.The resulting organic layer was spin-dryed under reduced pressure and then subjected to column chromatography.The target product N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine was obtained as a white solid.(N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine.Compound No. 2n)., 324579-90-0

As the paragraph descriping shows that 324579-90-0 is playing an increasingly important role.

Reference£º
Patent; South Medical University Zhongxiyi Binding Hospital; Zhu Zhibo; Zhou Jin; Yang Zike; Wang Hao; Liao Bohong; (21 pag.)CN107721991; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7305-71-7, 2-Amino-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Comparative Example 1 Synthesis of 2-chloro-5-methylthiazole In a 300 ml volume three necked flask equipped with a stirrer, a dropping funnel and a thermometer, 20 g of 2-amino5-methylthiazole (0.175 mol), 35 ml of 36% hydrochloric acid (0.407 mol) and 30 ml of water were placed and cooled to -5 C. To the mixture, 14 g of sodium nitrite (0.203 mol) dissolved in 30 ml of water was gradually added dropwise at 0 C. or lower. The reaction mixture was further caused to react for three hours at 0 C. or lower to give the diazonium base. The reaction mixture was heated to 80 C. for three hours and extracted with three 40 ml portions of chloroform to give a chloroform solution containing 2-chloro-5-methylthiazole. The chloroform was removed by atmospheric distillation and remained fraction was distilled under reduced pressure to isolate 10.3 g of 2-chloro-5-methylthiazole (0.077 mol) with a yield of 44%., 7305-71-7

Big data shows that 7305-71-7 is playing an increasingly important role.

Reference£º
Patent; Kureha Chemical Industry Co., Ltd.; US5811555; (1998); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica