Tag: M.W:100-200

19952-47-7, 2-Amino-4-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: A mixture of 2-aminobenzothiazole (0.150g, 1mmol), phenyl isothiocyanate (0.135g, 1 mmol) and Dimethyl amino pyridine (5 mol%) in DMF (1 mL) was stirred at room temperature for 2.0 h and the progress of the reaction was followed by TLC. After completion of the reaction, water (5 mL) was added to reaction mixture and extracted with ethyl acetate (2×5 mL). The organic layer was separated and dried over anhy. Na2SO4, and solvent was removed under reduced pressure. The crude product was purified by column chromatography (60-120 mesh) using (ethyl acetate: n-hexane, 10:90) to obtain 3a (0.256g, 90%) as a white powder.

19952-47-7, As the paragraph descriping shows that 19952-47-7 is playing an increasingly important role.

Reference£º
Article; Kumbhare, Ravindra M.; Dadmal, Tulshiram; Kosurkar, Umesh; Sridhar; Rao, J. Venkateswara; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 453 – 455;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56012-38-5,(2-Methylthiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

To a stirred solution of compound 64 (5 g, 38.75 mmol) in CH2C12 (150 mL) under inert atmosphere were added triethyl amine (8.3 mL, 58.13 mmol), methanesulfonyl chloride (4.6 mL, 46.51 mmol) at 0 C; warmed to RT and stirred for 4 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was diluted with water (50 mL) andextracted with CH2C12 (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford compound 65 (5 g, 87%) as a pale-yellow syrup. TLC: 30% EtOAc/ hexanes (Rf: 0.8); LC-MS: 77.92%; 147.7 (M+1) (column; Ascentis Express C18, (50 x 3.0 mm, 2.7 jim); RT 1.71 mm. 0.025% Aq. TFA + 5% ACN: ACN + 5% 0.025% Aq. TFA, 1.2 mL/min).

56012-38-5, 56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASSEMBLY BIOSCIENCES, INC.; TURNER, William; ARNOLD, Lee, Daniel; LI, Leping; BURES, Mark; HAYDAR, Simon; MAAG, Hans; BANNEN, Lynne; (176 pag.)WO2018/53157; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-79-9,2-Amino-4-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

5464-79-9, Step A. A solution of AICl3 (5 mmole) in ETSH (10 ML) was cooled to 0 C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole).. The mixture was stirred at 0-5 C. for 2 h.. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

5464-79-9 2-Amino-4-methoxybenzothiazole 21622, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Metabasis Therapeutics, Inc.; US6756360; (2004); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.4 5-(4-Hydroxy-3-nitrobenzylidene)-2-iminothiazolidin-4-one (14d) Orange solid; mp > 200 C; 330 mg, 61% yield; IR (neat) numax = 3164, 2772, 1679, 1604 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.46 (br s, 1H), 9.18 (s, 1H), 8.05 (s, 1H), 7.75 (d, J = 8.74, 1H), 7.55 (s, 1H), 7.24 (d, J = 8.72, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 180.71, 175.57, 153.52, 137.52, 136.46, 129.04, 127.52, 126.27, 125.66, 120.53 HRMS (ESI-TOF): m/z calculated for C10H7N3O4S [M+Na]+, 288.0055; found 288.0046.

As the paragraph descriping shows that 556-90-1 is playing an increasingly important role.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

348-40-3, 6-Fluorobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,348-40-3

Concentrated hydrochloric acid (0.067 mol) was added dropwise with stirring tohydrazine hydrate (0.12 mol) at 5-6 C followed by ethylene glycol (30 mL);thereafter, 6-uorobenzo[d]thiazol-2-amine (1) (20 mmol) was added in portionsand the resultant mixture was reuxed for 2-3 h and cooled at room temperature.The reaction progress was monitored by TLC using toluene:ethylacetate (75:25) asmobile phase. The reaction mixture was ltered and the resulting precipitates werewashed with distilled water. The resulting crude was recrystallized from ethanol. IR(KBr) mmax: 3010 (=C-H str), 1645 (C=C str), 1398 (C=N str). The 1HNMR(DMSO-d6) spectrum of this product showed signals: d 7.2-7.4 (3H, m, Ar C-H), at4.0 (1H, br, NH) and 4.75 (2H, br, NH2) ppm. The peaks in its 13CNMR (DMSO-d6)d: 106.1, 112.4, 115.5, 129.7, 145.5, 157.5, 171.2 ppm.

The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kukreja, Sharu; Sidhu, Anjali; Sharma, Vineet K.; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 8329 – 8344;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

51640-36-9,51640-36-9, 2-Chlorothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-{[2-(4-acetylpiperazin-1-yl)pyrimidin-4-yl]amino}-1,3-thiazole-5-carbonitrile (4-5) 2-(4-acetylpiperazin-1-yl)pyrimidin-4-amine 4-4 (0.1 g, 0.45 mmol) was dissolved in dry TBF and then 1 equivalent of sodium hydride (0.036 g, 0.45 mmol) was added and this was stirred for 20 minutes at 25 C. then 2-chloro-1,3-thiazole-5-carbonitrile 2-2 (0.065 g, 0.45 mmol) was added followed immediately by 1 more equivalent of sodium hydride. The reaction was then stirred at 100 C. for 3 hours. The reaction was cooled to 25 C. and methanol was added. This solution was loaded directly onto a silica column and eluted with DCM:MeOH:NH4OH (95:5:0.5). Fractions were combined and evaporated to yield the product, 4-5. Hi-Res MS: calc: 330.1132 found: 330.1137. 1H-NMR (DMSO): 8.33 ppm (s, 1H); 8.19 ppm (d, 1H); 6.34 ppm (d, 1H); 3.88 ppm (m, 2H); 3.80 ppm (m, 2H); 3.57 ppm (m, 4H); 2.07 ppm (s, 3H).

The synthetic route of 51640-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bilodeau, Mark T.; Hartman, George D.; Hoffman JR., Jacob M.; Sisko, John T.; Manley, Peter J.; Smith, Anthony M.; Tucker, Thomas J.; Lumma JR., William C.; Rodman, Leonard; US2002/137755; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-06-9,4-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: Compound 9 (0.1mmol) added to dry CH2Cl2 (15mL) was stirred at 0C and oxalyl chloride (2.0mmol) was dripped into the mixture and stirred at the same temperature for 12h. After the reaction, the solvent and excess oxalyl chloride was evaporated under the reduced pressure, then add CHCl3. Compounds 2 (0.1mmol) and triethylamine (0.15mmol) were added to the mixture and reflux at 65C for 5h. After the reaction, the solvent was evaporated under reduced pressure, and the crude product was purified by chromatography on silica gel eluted with petroleum CH2Cl2/CH3OH (V: V=60:1) to offer the target compounds 11a-11k in good yields., 20358-06-9

As the paragraph descriping shows that 20358-06-9 is playing an increasingly important role.

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Article; Jin, Le; Huang, Rizhen; Huang, Xiaochao; Zhang, Bin; Ji, Min; Wang, Hengshan; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1759 – 1775;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 309 /V-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H- pyrazolo[3,4-/j]pyridin-5-yl]methyl}-2-methyl-1,3-thiazoIe-4-carboxamide2-Methyl-1 ,3-thiazole-4-carboxylic acid [e.g. available from Acros Organics] (125mg) was dried overnight under vacuum over phosphorus pentoxide and was then suspended in dry dichloromethane (2ml) and treated at 2O0C with oxalyl chloride (0.077ml) and DMF (1 drop). The mixture was stirred at room temperature for 25mins and was then added dropwise to a solution of Intermediate 16 (240mg) in anhydrous acetonitrile (5ml). DIPEA (0.155ml) was added and the solution stirred at room temperature for 3h. The solution was blown down to dryness and purified by mass directed autoprep HPLC to give a pale orange gum. The gum was further purified using an SPE cartridge (5g, aminopropyl) which had been pre-washed with methanol. Elution with methanol gave Example 309 as a pale orange gum (287mg). LCMS showed MH+ = 429; TRET = 2.37min., 35272-15-2

The synthetic route of 35272-15-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

101012-12-8, 2-Chloro-1,3-thiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred solution of 2-chlorothiazole-5-carboxylic acid (compound of formula XIV) (25 g, 152.8 mmol) in thionyl chloride (54.54 g, 458 mmol, 3 eq) and a catalytic amount of DMF were heated at 1 10C for 16 hours. Then excess thionyl chloride was removed to give 28.3 g of crude 2-chlorothiazole-5- carbonyl chloride XV. In a sealed tube PCI5 (102 g, 489 mmol, 3.2 eq) was added to the acid chloride and the mixture was heated at 190C for 48 hours. The reaction mixture was slowly poured into ice water keeping the temperature below 10C. The flask was washed with dichloromethane and the aqueous phase was extracted with dichloromethane (3 X 200 ml). The combined organic phases were washed with water (1 x 100 ml) and brine (1 x 100 ml), dried over anhydrous Na2S04 and concentrated to give 42.5 g of crude material. The residue was dissolved in 100 ml dichloromethane, 100 ml 10% NaOH solution was added, and the mixture was stirred for 1 hour. The phases were separated and the aqueous phase was extracted with dichloromethane. The combined organic phases were washed with water and brine, dried over anhydrous Na2S04, and concentrated. The residue was purified through silica gel column using hexane as an eluent. 22.2 g (92.7 mmol) of product XIII were obtained (yield 61.3%).

101012-12-8, As the paragraph descriping shows that 101012-12-8 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; HUETER, Ottmar, Franz; HOPPE, Mark; SMEJKAL, Tomas; DUMEUNIER, Raphael; FEDOU, Nicolas; GODINEAU, Edouard; WEGE, Philip; MAIENFISCH, Peter; (61 pag.)WO2019/81575; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3364-80-5

General procedure: A solution of substituted o-phenyldiamine (1.0 equiv), thiazole-4-aldehyde or pyridine-2-aldehyde (1.0 equiv) with sodium pyrosulfite in DMF was stirred at 120¡ã C overnight. On completion of the reaction monitored by TLC, the solvent was evaporated and the residue was purified by silica gel chromatography by DCM/MeOH system to afford the final product. If necessary, the crudeproduct could be recrystallized in DCM or dichloroethane to afford pure sample.

The synthetic route of 3364-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Chao; Zhong, Bo; Yang, Simin; Pan, Liangkun; Yu, Siwang; Li, Zhongjun; Li, Shuchun; Su, Bin; Meng, Xiangbao; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3774 – 3780;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica