Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,615-21-4

14.5 g (87.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 200 ml ofDMF under a nitrogen stream in a four-necked reactor equipped with a thermometer. To this solution were added 36.3 g (263 mmol) of potassium carbonate and 25.0 g (105 mmol) of 1,1,1-trifluoro-4-iodobutane and the whole mass was stirred at 80 C. for 8 hours. After completion of the reaction, the reaction solution was cooled to 20 C. and added to 1,000 ml of water, and the mixture was extracted with 1,000 ml of ethyl acetate. After drying the ethyl acetate layer over anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off under reduced pressure from the filtrate on a rotary evaporator to afford a yellow solid. This yellow solid was purified by silica gel column chromatography (n-hexane/ethyl acetate=85:15) to afford 9.61 g of compound (3m) as a white solid (yield: 39.9%). The structure of the target product was identified by 1H-NMR .1H-NMR(500 MHz, CDC13 , TMS, oppm): 7.61(d, lH, 1=8.0 Hz), 7.54(d, lH, 1=7.8 Hz), 7.30(dd, lH, 1=7.8 Hz, 7.8 Hz), 7.09(dd, lH, 1=7.8 Hz, 8.0 Hz), 4.24(s, 2H), 3.81(t, 2H, 1=7.0 Hz), 2.16-2.26(m, 2H), 1.99-2.05(m, 2H)

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, Kei; OKUYAMA, Kumi; SANUKI, Kanako; (45 pag.)US2018/99921; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7504-44-1,7504-44-1, 2-(4-Thiazolyl)acetic Acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

HATU (2.12 g, 5.58 mmol) was added to a mixture containing of 2-((lr, 4r)-4-((5 -amino-i -(phenyl sulfonyl)- 1H-pyrrolo[2,3 -b]pyridin-4- yl)amino)cyclohexyl)acetonitrile (Intermediate 2, 1.14 g, 2.78 mmol), 2-(thiazol-4-yl)acetic acid(400 mg, 2.79 mmol), DIPEA (722 mg, 5.59 mmol)and DMF (10 mL) at 0 C (ice / water) and was stirred at room-temperature for 2 hours. The reaction was partitioned between EtOAc (100 mL) and water (100 mL), the aqueous phase was extracted with ethyl acetate (50 mL x 3) and the combined organic extracts were dried over anhydrous Na2504, filtered, and concentrated to dryness. The residue was purified by flash column chromatography to provide the titlecompound (1.5 g, 95% yield) as a yellow solid. MS (ESI): mass calcd. for C26H26N60352,534.65; m/z found, 534.9 [M+H]t

7504-44-1 2-(4-Thiazolyl)acetic Acid 236262, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BACANI, Genesis M.; CHAI, Wenying; KOUDRIAKOVA, Tatiana; KRAWCZUK, Paul J.; KREUTTER, Kevin D.; LEONARD, Kristi; RIZZOLIO, Michele C.; SEIERSTAD, Mark; SMITH, Russel C.; TICHENOR, Mark S.; VENABLE, Jennifer D.; WANG, Aihua; (452 pag.)WO2018/112382; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of 1,2-benzisothiazol-3-one 1 (151 mg, 1 mmol), inTHF (10 ml), K2CO3 (276 mg, 2 mmol) was added at room temperaturefor 30 min, then t-butyl bromoacetate 10 (195 mg, 1 mmol)was added. After the reaction was stirred at room temperaturefor 3 h, the solvent was removed under vacuum. The residualwas isolated by column chromatography (ethyl acetate/petroleumether, 15:1) to yield 11. The intermediate 11 (265 mg, 1 mmol) indry CH2Cl2 (10 ml) was treated with trifluoroacetic acid (TFA,3.3 ml) for 5 h at room temperature and the solvent was removedunder vacuum. The residue washed with ethyl ether (2 25 ml) toyield the desired product 12 as white solid. A solution of compound 12 (209 mg, 1 mmol) in dry THF(10 ml) was added portion wise to a suspension of carbonyldiimidazole(162 mg, 1 mmol) in THF (5 ml) and the mixture was stirredat room temperature for 20 min and then refluxed for 10 min.A solution of primary amine (1 mmol) in THF (5 ml) was addedand the reaction mixture was stirred at room temperature overnight.A white precipitate formed, which was collected by suctionfiltration.

2634-33-5, The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Lixin; Lu, Meiqi; Yan, Zhihui; Tang, Xiaobin; Sun, Bo; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 8; (2014); p. 2416 – 2426;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

556-90-1, General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.3 5-(4-Hydroxy-3-methoxybenzylidene)-2-iminothiazolidin-4-one (14c) Yellow solid; mp > 200 C; 215 mg, 43% yield; IR (neat) numax = 3364, 2955, 1735, 1680, 1584 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.76 (s, 1H), 9.29 (br s, 1H), 9.05 (s, 1H), 7.50 (s, 1H), 7.13 (s, 1H), 7.06 (d, J = 8.28, 1H), 6.9 (d, J = 7.92, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 175.91, 148.92, 148.35, 130.35, 125.94, 125.81, 123.69, 116.49, 113.88, 56.00; HRMS (ESI-TOF): m/z calculated for C11H10N2O3S [M+H]+, 251.0490; found 251.0491.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

78364-55-3, General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

The synthetic route of 78364-55-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

29927-08-0, 5,6-Dimethylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Preparation of acetoacetamide derivatives (3a-e) was carried out as shown in Scheme 1. 2,2,6-Trimethyl-1,3- dioxine-4-one (1) (2eq) and appropriate arylamine (2a-e) (1eq) were mixed and refluxed for about 2-4h in toluene. The progress of the reactions was checked by TLC. Upon completion of the reaction, the product was filtered, washed with small portions of petroleum ether. Further purification was performed by crystallization of obtained product in hot ethanol. Characteristics data for prepared N-(aryl)-3- oxobutanamides are as follows:

29927-08-0, The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ebadi, Ahmad; Khoshneviszadeh, Mehdi; Javidnia, Katayoun; Ghahremani, Mohammad Hossein; Firuzi, Omidreza; Miri, Ramin; Letters in drug design and discovery; vol. 14; 8; (2017); p. 885 – 897;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.

2- (3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) imidazo [1,2- a] pyridine(100 mg, 0.31 mmol),Palladium acetate (4 mg, 0.016 mmol),Triphenylphosphine (16 mg, 0.06 mmol),And sodium carbonate (66 mg, 0.62 mmol)After adding 1,4-dioxane and water at a ratio of 1: 1 in 2 mL portions4-Bromothiazole (51 mg, 0.31 mmol) was added thereto, and the mixture was stirred at 90 ¡ã C for 16 hours.After the reaction is completed, the reaction mixture is cooled to room temperature and the reaction product is separated into water and ethyl acetate. The combined organic layers were concentrated and the concentrate was purified by silica gel column chromatography (dichloromethane: ethyl acetate, 10: 1 v / v) to give 4- (3- (imidazo [1,2- a] pyridin- ) Phenyl) thiazole (45 mg, 52percent).

34259-99-9, As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Jeon Mun-guk; Kim Gwang-rok; Huh Yun-jeong; Lee Jun-mi; (27 pag.)KR2018/101671; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1826-11-5,2-Phenylthiazole,as a common compound, the synthetic route is as follows.

4.3.1.6 2-Phenylthiazole 11 Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1a (4.4 mg) gave [2′,6′-2H2]-11 (12.2 mg, 89%, 82%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1b (4.6 mg) gave [2′,6′-2H2]-11 (11.0 mg, 80%, 44%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1c (3.8 mg) gave [2′,6′-2H2]-11 (13.6 mg, 98%, 72%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 5 (3.4 mg) gave [2′,6′-2H2]-11 (10.8 mg, 78%, 59%D). deltaH (300 MHz, DMSO-d6) 7.97-7.93 (m, 3H), 7.78 (d, 1H, J=3.3 Hz), 7.54-7.48 (m, 3H).

1826-11-5, As the paragraph descriping shows that 1826-11-5 is playing an increasingly important role.

Reference£º
Article; Atzrodt, Jens; Derdau, Volker; Kerr, William J.; Reid, Marc; Rojahn, Patrick; Weck, Remo; Tetrahedron; vol. 71; 13; (2015); p. 1924 – 1929;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

6633-61-0,6633-61-0, Methyl 2-aminothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE I Preparation of Methyl 2-chlorothiazole-5-carboxylate To 5.0 g of methyl 2-aminothiazole-5-carboxylate [H. E. Faith, U.S. Pat. No. 2,405,820(1946)] suspended in 54 ml of 6 N hydrochloric acid stirred at-5-0 was added dropwise over 15 minutes 3.7 g of sodium nitrite dissolved in 10 ml of water. After stirring 5 minutes, the brown suspension was added in one portion to a rapidly stirred suspension of 10.6 g of cupric sulfate and 10.6 g of sodium chloride cooled at 5. The cooling bath was removed and stirring was continued for 30 minutes. The pH was adjusted to 7.3 with 6 N sodium hydroxide and the green suspension was filtered through Celite. The solid was washed with three portions of ethyl acetate and the extract was combined with the ethyl acetate extract of the original filtrate. After drying the combined extract over magnesium sulfate, concentration in vacuo gave a brown solid. Trituration with four portions of hot petroleum ether (35-60) served to separate the soluble product from some starting material. Concentration in vacuo of the petroleum ether solution gave 3.9 g. of pure methyl 2-chlorothiazole-5-carboxylate having a melting point of 41-46.

The synthetic route of 6633-61-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4168380; (1979); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-60-7,2-Methylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

A solution of 2-methylthiazole-5-carbaldehyde (1 g, 7.86 mmol) and ethyl 2-azidoacetate (30% in DCM, 15.8 ml_, 31 .5 mmol) was added dropwise to a solution of NaOEt (21 % in EtOH, 1 1 .7 ml_, 31 .5 mmol) and EtOH (40 ml.) at 0. After stirring for 1 hour at 0C, the temperature was allowed to come to RT and the stirring was continued for another hour. The mixture was quenched with a saturated solution of NH4CI and extracted with Et20. The organic extract was dried over Na2S04, filtered and evaporated. Purification by column chromatography on silica gel using cyclohexane and EtOAc (from 0% to 30%) provided the title compound as brown solid. 1 H NMR (400 MHz, DMSO-d6) d (ppm) 8.07 (d, 1 H), 7.27 (d, 1 H), 4.31 (q, 2H), 2.69 (s, 3H), 1 .32 (t, 3H). LC-MS: Rt = 1 .05 min; MS m/z [M+H]+ 239.1

1003-60-7, As the paragraph descriping shows that 1003-60-7 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; FARADY, Christopher; GOMMERMANN, Nina; JANSER, Philipp; MACKAY, Angela; MATTES, Henri; STIEFL, Nikolaus Johannes; VELCICKY, Juraj; (148 pag.)WO2020/21447; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica