Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-66-0,2,5-Dimethylthiazole,as a common compound, the synthetic route is as follows.

To a solution of 2, 5-dimethylthiazole (0.730 g, 5.10 mmol) in benzene (80 mL). add N-bromosuccinimide (0.908 g, 5.10 mmol) and a catalytic amount of benzoyl peroxide. Heat the solution at reflux for 2 hours and stir overnight at room temperature. Cool the mixture, dilute with diethyl ether, wash with saturated NA2*S03 (75 mL), followed by saturated sodium hydrogencarbonate (75 mL), dry (NA2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 100% diethyl ether to afford 390 mg of the title compound. IN NMR (CDCL3) 67. 39 (s, 1H), 4.70 (s, 2H), 2.48 (s, 3H).

4175-66-0, As the paragraph descriping shows that 4175-66-0 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-formaldehyde thiazole (113 mg, 1mmol) dissolved in 2 ml methanol, by adding 2-hydroxypropanedinitrile acetic acid solution (0.4 ml, 5mol/L), then rapidly added to 4-dimethyl aminopyridine (12 mg), 50 ¡ãC stirring under 40 minutes. After concentrating the reaction solution through the column chromatography separation to obtain 4 – (hydroxy-a)-thiazole acetic acid methyl ester (144 mg, 83percent)., 3364-80-5

As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.

Reference£º
Patent; Shanghai Syn-The-All Pharmaceutical Co. Ltd.; Zhang, ZhiLiu; Lin, XiaoJuan; Yu, Haiyu; Wu, Chengde; Ma, RuJian; Chen, ShuHui; (8 pag.)CN103086881; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

78364-55-3, General procedure: 6-Fluoro-2-(2-(5-(un)substituted-2-oxoindolin-3-ylidene)hydrazino)benzothiazoles 5a-c. General Procedure C. A mixture of compound 2 (0.183 g, 0.001 mol), the appropriate isatin (0.001 mol) and glacial acetic acid (0.1 mL) in ethanol (20 mL) was heated at reflux temperature for 4-6 h. The precipitated yellow to orange solid was collected by filtration, washed with ethanol, dried and crystallized from methanol to yield compounds 5a-c.

As the paragraph descriping shows that 78364-55-3 is playing an increasingly important role.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-bromothiazole-5-carbonitrile (259 mg, 1.37 mmol), 6-phenylpiperidin-2-one (200 mg, 1.14 mmol), cesium carbonate (558 mg, 1.71 mmol), XantPhos (52.8 mg, 0.091 mmol),and Pd(Ph3P)4 (132 mg, 0.114 mmol) in dioxane (3 mL) in a sealed tube was heated at 125 C for 18 h under N2. The reaction mixture was cooled to room temperature and partitioned between water (20 mL) and ethyl acetate (30 mL x 2). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by reverse-phase prep-HPLC (preparative HPLC on a GILSON 281 instrument fitted with Waters XSELECT C18 l5Ox3Ommx5um using water and acetonitrile as the eluents, mobile phase A:water, mobile phase B: acetonitrile (containing: 0.1%TFA-ACN), gradient: 38-68%, 0-10 mm; 100% B, 10.5-12.5 mm; 5% B, 13-15 mm) to give 2-(2-oxo-6-phenylpiperidin-1-yl)thiazole-5- carbonitrile as a solid. ESI-MS m/z [M+Hf?: 284.0.

440100-94-7, 440100-94-7 2-Bromothiazole-5-carbonitrile 17860952, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; WALJI, Abbas; BERGER, Richard; STUMP, Craig, A.; SCHLEGEL, Kelly Ann, S.; MULHEARN, James, J.; GRESHOCK, Thomas, J.; GINNETTI, Anthony, T.; WANG, Deping; STACHEL, Shawn, J.; FRALEY, Mark, E.; (87 pag.)WO2017/222950; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of aluminum lithium hydride (671 mg) in THF (20 ml), a solution of 2-thiazolecarboxyaldehyde (2.0 g) in THF (20 ml) was added dropwise at 0C under nitrogen atmosphere. After finishing the dropping, water (0.7 ml), 15% aqueous solution of sodium hydroxide (0.7 ml), and water (2.1 ml) were sequentially added to the mixture at 0C, and the mixture was stirred for 2.5 hours at room temperature. The mixture was dried over magnesium sulfate, and the insolubles were filtered off. The solvent was distilled off under reduced pressure, to give 2-hydroxymethylthiazole (1.0 g) as brown oil. 1H-NMR (200 MHz, CDCl3) delta 4.98 (2H, s), 7.33 (1H, d, J = 3.4 Hz), 7.75 (1H, d, J = 3.0 Hz), 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1422228; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

155559-81-2, 5-Fluorobenzo[d]thiazole-2-thiol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 4?-demethylepipodophyllotoxin (DMEP) (400mg 1mmol) and SH-containing building blocks in dichloromethane (15mL) at 0C was mixed with 1mL of TFA as the catalyst. After stirring the reaction mixture for 2-3hat room temperature and maximal conversion was reached (3h, monitored by TLC), the resultant mixture was washed with saturated NaHCO3 (20mL¡Á2) and extracted with CH2Cl2 (45mL¡Á2). The organic layer was dried over MgSO4, and the solvent was evaporated to give a crude residue, which was purified by flash column chromatography (petroleum ether: dichloromethane: ethyl acetate, 3:2:1) to afford the target compounds. The purity of compounds was determined by HPLC with a thermo-C18 (250mm¡Á4.6mm, 5mum) column as the stationary phase and methanol-water (35:65) as the mobile phase at ambient temperature and a flow rate of 2.0mL/min., 155559-81-2

155559-81-2 5-Fluorobenzo[d]thiazole-2-thiol 2774531, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Qing-Yun; Zhao, Wei; Tang, Ya-Jie; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 951 – 964;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

615-21-4, In a three-neck reactor equipped with a thermometer,In a nitrogen stream,10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 150 ml of DMF.To this solution,39.4 g (121.0 mol) of cesium carbonate was added and the mixture was cooled to 0 C.,16.4 g (72.5 mmol) of iodoheptane was added dropwise over 5 minutes,After completion of the dropwise addition, the whole contents were stirred at 25 C. for 3 hours.After completion of the reaction, 1000 ml of water was added to the reaction solution,And extracted twice with 500 ml of ethyl acetate.After drying the organic layer with anhydrous sodium sulfate,Sodium sulfate was filtered off.After concentrating the filtrate with a rotary evaporator,The concentrate was purified by silica gel column chromatography (n-hexane: ethyl acetate = 85: 15)9.05 g of Intermediate P was obtained as a white solid (yield 56.9%).

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP2017/206554; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isatin (5 mmol) was dissolved in methanol (40 mL), and corresponding reactants(amine (R-NH2, 5 mmol) and glacial acetic acid (1 mL) in the given order) were added.Reaction mixture was refluxed at 70 C for 6 h under stirring at atmospheric pressure.ubsequently, the mixture was left overnight without stirring at room temperature. Theobtained crystals were filtered off, dried and recrystallized from methanol. On average, theyield was about 70-79 % (details are given in the Supplementary material)., 121-66-4

The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; ?ekularac, Gavrilo M.; Nikoli?, Jasmina B.; Petrovi?, Predrag; Bugarski, Branko; Durovi?, Boban; Drmani?, Sa?a ?.; Journal of the Serbian Chemical Society; vol. 79; 11; (2014); p. 1347 – 1354;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19759-66-1,2-Aminobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

General procedure: To a solution of thiophene-2-carbonyl chloride (2a) or3-chlorothiophene-2-carbonyl chloride (2b) in dry tolueneor DMF, corresponding anilines and amino-pyridines 1a-1f, 2-amino-6-subtituted-benzimidazoles 10a-10c, or2-amino-6-substituted-benzothiazoles 10d-10f were added,followed by the addition of Et3N. The mixture was refluxedfor several hours. After cooling, the resulting products werefiltered off and washed with diluted HCl and recrystallizatedfrom ethanol/DMF to obtain heteroaromaticcarboxamides 3a-3f and 11a-11h.

19759-66-1, The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sovi, Irena; Viski, Marko; Bertoa, Branimir; Ester, Katja; Kralj, Marijeta; Hranjec, Marijana; Karminski-Zamola, Grace; Monatshefte fur Chemie; vol. 146; 9; (2015); p. 1503 – 1517;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56354-98-4,6-Aminobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.,56354-98-4

General procedure: To a stirred suspension of benzo [d]oxazol-2(3H)-one derivative,or benzimidazole, or 2H-benzo [b] [1,4]oxazin-3(4H)-one(1.0 mmol), anhydrous K2CO3 (1.2 mmol) was added in the DMFsolvent for 20 min at 70 C. Then bromoacetylated 1a-1f or 2a-2c(1.3 mmol) and TBAI (0.1 mmol) were added simultaneously. Thereaction was stirred and heated for 4 h. After completion, themixture was extracted with EtOAc/H2O three times. The combinedorganic layers were washed with brine, dried over anhydrousNa2SO4, filtered and concentrated under reduced pressure. Thecrude product was purified by silica gel column chromatographyeluting with EtOAc/PE (3:1e8:1) to afford compounds B01-B29,C01-C03.

As the paragraph descriping shows that 56354-98-4 is playing an increasingly important role.

Reference£º
Article; Yang, Lixin; Liu, Yongqing; Fan, Minghua; Zhu, Guiwang; Jin, Hongwei; Liang, Jing; Liu, Zhenming; Huang, Zhuo; Zhang, Liangren; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica