Tag: M.W:100-200

78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78364-55-3

General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-12-2,Thiazol-2-ylmethanol,as a common compound, the synthetic route is as follows.,14542-12-2

This material (3.4 g, 29.6 mmol, 1 eq) was treated with TBDPSCI (8.94 g, 1.1 eq),imidazole (4.0 g, 2 eq) in 20 mL DCM. The mixture was stirred for 14 h. After removalof solvent, extraction with EtOAc and drying the organic layer with Na2C03,evaporation of the solvent afforded 10.5 g of the desired product quantitavely.1HNMR(CDCI35): 1.1 (s, 9 H) 4.90.(s, 2H) 7.30-7.40 (m, 7 H) 7.60-7.70 Patent; SCHERING CORPORATION; WO2006/19957; (2006); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Amino-thiazole-4-carboxylic acid ethyl ester (460 mg) obtained in the same manner as in Chem. Pharm. Bull, 19(1) 119-123 (1971) was dissolved in ethanol (7 ml). Hydrazine monohydrate (1.3 ml) was added to this solution and the mixture was refluxed at 100C for 22 hr. The reaction mixture was cooled to room temperature and the obtained solid was collected by filtration and washed with ethanol. This solid was dried in vacuo to give the title compound (280 mg).1H-NMR(?, 300MHz, DMSO-d6) 4.26(2H,s),7.07(2H,s),8.00(1H,s),8.83(1H,s)., 18903-18-9

The synthetic route of 18903-18-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Japan Tobacco Inc.; EP1452526; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

30 mg (0.19 mmol) of 4,5,6,7-tetrahydrobenzo [d] thiazol-2-amine 53 mg (0.19 mmol) of 2, 4′-dibromoacetophenone was dissolved in 3 ml of ethanol and stirred in a microwave reactor at 150 C for 20 minutes. The residue was concentrated under reduced pressure and subjected to column chromatography (EtOAc: Hex = 1: 5) to obtain Compound 2c (14 mg, 22%)., 2933-29-1

2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Chung-Ang University Industry-Academic Cooperation Foundation; Min, Kyung Hoon; Kwon, Ahra; Song, Ji Ho; (22 pag.)KR2017/23387; (2017); A;,
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Thiazole | chemical compound | Britannica

19759-66-1, 2-Aminobenzothiazole-6-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.88g (0.005 mol) 2-amino-6-cyanobenzothiazole was dissolved in 10 mL of N,N-dimethylformamide, 0.4 g (0.01 mol) of sodium hydroxide was added with stirring, After 10 minutes, 1.26 g (0.005 mol) of 2,6-dichloro-3,5-dinitrotoluene was added thereto, The reaction was continued at room temperature for 5 hours. After completion of the TLC monitoring reaction, the reaction solution was poured into 50 mL of saturated brine and extracted with ethyl acetate. The organic phase was extracted with anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography (eluent ethyl acetate and petroleum ether (Boiling range 60-90 C) in a volume ratio of 1:10) to give 0.40 g of compound 4405, Yellow solid. Melting point 229-231 C., 19759-66-1

The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.

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Patent; SINOCHEM CORP; Shenyang Research Institute Of Chemical Industry Co., Ltd .; GUAN, AIYING; LI, HUICHAO; SUN, QIN; LIU, CHANGLING; WANG, JUNFENG; SUN, XUFENG; YANG, FAN; (21 pag.)CN104177310; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

Manufacturing Example 88-1-1 Thiazole-2-yl-methanol; To a mixture of 2-formylthiazole (300 mg, 2.65 mmol) and methanol (30 mL) was added sodium borohydride (201.0 mg, 5.30 mmol) at 0 C., which was stirred for 1 hour at room temperature. Water was added to this reaction mixture, which was then extracted with ethyl acetate. The organic layer was separated, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure, and the residue was purified by NH silica gel column chromatography (diethyl ether) to obtain the title compound (251.2 mg, 82%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.74 (2H, d, J=6.0 Hz), 6.04 (1H, t, J=6.0 Hz), 7.63-7.65 (1H, m), 7.73-7.75 (1H, m)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4-cyanothiazole (5.0 g, 45.0mmol) in o-dichlorobenzene (40.0 mL) was added the respective aniline (1) (49.0 mmol). The reaction mixture was heated at 135 C with purging excess dry HCl for 3 h. Then, cooled the reaction mixture to 40 C and the resulting solids were filtered, washed with more o-dichlorobenzene (10.0 mL). The solids were dried at 90 C under vacuum to give amidine hydrochlorides with yields in the 70-90% range., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Patil, Vikrant; Barragan, Enrique; Patil, Shivaputra A.; Patil, Siddappa A.; Bugarin, Alejandro; Tetrahedron Letters; vol. 58; 35; (2017); p. 3474 – 3477;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.,2634-33-5

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.19 2-(3-(2-Methoxyphenyl)propanoyl)benzo[d]isothiazol-3(2H)-one (23) Compound 23 was prepared through 3-(2-methoxyphenyl)propionic acid, obtained a white solid in 93% yield. Mp 149.5-150.7 C. 1H NMR (400 MHz, CDCl3) delta 8.00 (d, J = 8.0 Hz, 1H), 7.68 (t, J = 8.0 Hz, 1H), 7.51 (d, J = 8.0 Hz, 1H), 7.39 (t, J = 8.0 Hz, 1H), 7.25-7.17 (m, 2H), 6.89 (t, J = 8.0 Hz, 1H), 6.85 (d, J = 8.4 Hz, 1H), 3.82 (s, 3H), 3.47 (t, J = 7.6 Hz, 2H), 3.09 (t, J = 7.6 Hz, 2H). 13C NMR (101 MHz, DMSO-d6) delta 172.9, 163.5, 157.6, 141.4, 135.0, 130.2, 128.6, 128.1, 127.4, 126.5, 125.7, 122.5, 120.8, 111.1, 55.7, 37.5, 24.9. IR (KBr, cm-1): 1689, 1675. HRMS-ESI (m/z) calcd for C17H15NO3S [M+H+] 314.0851, found 314.0843.

The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51640-36-9,2-Chlorothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

To an NMP (1 mL) solution of (trans)- 3-(5-fluoro-2-methoxyphenoxy)-/V-(pyrrolidin-3- yl)cyclobutanecarboxamide hydrochloride (Intermediate 70) (38 mg, 0.1 1 mmol) and 2- chlorothiazole-5-carbonitrile (16 mg, 0.1 1 mmol) in a microwave reaction vial was added N,N- diisopropylethylamine (0.08 mL, 0.4 mmol). The reaction was heated in a microwave (135 C) for 3.5 h, concentrated and loaded onto a semi-prep HPLC (NH4OH as modifier) for purification to afford the title compound as a tan solid (31 mg, 62%). 1H NMR (400 MHz, CDCI3) delta 2.09 (dd, J = 13, 7 Hz, 1 H), 2.42 (dd, J = 13, 6 Hz, 1 H), 2.46-2.58 (m, 2 H), 2.74 (ddd, J = 14, 7, 4 Hz, 2 H), 2.95-3.04 (m, 1 H), 3.40 (dd, J = 1 1 , 4 Hz, 1 H), 3.57-3.69 (m, 2 H), 3.81 -3.89 (m, 1 H), 3.84 (s, 3 H), 4.64-4.74 (m, 1 H), 4.94 (t, J = 7 Hz, 1 H), 5.59-5.72 (m, 1 H), 6.47 (dd, J = 10, 3 Hz, 1 H), 6.59 (td, J = 8, 3 Hz, 1 H), 6.78 (dd, J = 9, 5 Hz, 1 H), 7.71 (s, 1 H); LC-MS (LC- ES) M+H = 417., 51640-36-9

51640-36-9 2-Chlorothiazole-5-carbonitrile 1485222, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, David Norman; GUO, Yu; HANCOCK, Ashley Paul; SCHULTE, Christie; SHEARER, Barry George; SMITH, Emilie Despagnet; STEWART, Eugene L.; THOMSON, Stephen Andrew; (556 pag.)WO2018/69863; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

In a four-neck reactor equipped with a thermometer, in a nitrogen stream, 10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 150 ml of DMF. To this solution, Cesium carbonate 39.4 g (121.0 mmol) of 9.65 g of 1-bromo-2-butyne (72.5 m Mol) was added, and the whole mixture was stirred at 25 C. for 20 hours. After completion of the reaction, the reaction solution was washed with water 1000 m L and extracted with 500 ml of ethyl acetate. After drying the ethyl acetate layer with anhydrous sodium sulfate, Sodium sulfate was filtered off. In a rotary evaporator, Ethyl acetate was distilled off from the filtrate under reduced pressure to obtain a brown solid. The brown solid was purified by silica gel column chromatography (N-hexane: ethyl acetate = 85: 15) To obtain 6.25 g of Intermediate S (yield: 47.5%) as a white solid.

615-21-4, As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (78 pag.)JP6090514; (2017); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica