Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120-75-2,2-Methylbenzothiazole,as a common compound, the synthetic route is as follows.

Example 9 (0081) Preparation of Compound (39) (0082) (0083) 2 g of 2-Methyl benzothiazole and 5 g of 1,3-propanesultone in 20 mL chlorobenzene was heated at 120 C. overnight. Then 30 mL ethyl acetate was added, and resulting mixture was refluxed for 30 min. The supernatant was decanted and the residue was dried to give compound 38.

120-75-2, As the paragraph descriping shows that 120-75-2 is playing an increasingly important role.

Reference£º
Patent; Ying, Laiqiang; (24 pag.)US9850382; (2017); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.247037-82-7,Thiazole-2-carboximidamide hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of 3-oxobutanamide (3 g, 29 mmol), 2-chloro-4-fluorobenzaldehyde (4.9 g, 29 mmol), 1,3-thiazole-2-carboximidamide HCl salt (5 g, 29 mmol) and KOAc (6 g, 58 mmol) in CF3CH2OH (50 mL) was stirred for 24 hours at 90 C. After being cooled, it was concentrated and partitioned (EtO Ac-brine). The organic was dried (Na2SO4), filtered and concentrated. The residue was chromatographed (silica, ethyl acetate/petroleum ether) to give the desired compound as a yellow solid (1.2 g, 21%). ESIMS m/z = 350.95, 352.95 [M+H]+.

247037-82-7, The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; CAO, Hui; LI, Wei; PENG, Xiaowen; JIN, Meizhong; KASS, Jorden; GAO, Xuri; OR, Yat, Sun; (99 pag.)WO2017/11552; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

38585-74-9, Thiazol-5-ylmethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D. ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate A solution of 3.11 g (27 mmol) of 5-(hydroxymethyl)thiazole and excess N-methyl morpholine in 100 ml of methylene chloride was cooled to 0 C. and treated with 8.2 g (41 mmol) of 4-nitrophenyl chloroformate. After being stirred for 1 h, the reaction mixture was diluted with CHCl3, washed successively with 1N HCl, saturated aqueous NaHCO3, and saturated brine, dried over NaSO4, and concentrated in vacuo. The residue was purified by silica gel chromatography (SiO2, 1-2% MeOH/CHCl3, Rf=0.5 in 4% MeOH/CHCl3) to yield 5.9 g (78%) of the desired compound as a yellow solid. NMR (CDCl3) delta5.53 (s, 2H), 7.39 (dt, J=9, 3 Hz, 2H), 8.01 (s, 1H), 8.29 (dt, J=9, 3 Hz, 2H), 8.90 (s, 1H). Mass spectrum: (M+H)+ =281.

38585-74-9, As the paragraph descriping shows that 38585-74-9 is playing an increasingly important role.

Reference£º
Patent; Abbott Laboratories; US5914332; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7709-58-2, 4-(Chloromethyl)thiazole hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part 8; Independently during this time, 4-(chloromethyl)-1,3-thiazole hydrochloride (59.84 g, 352 mmol) was freshly converted to the free base as follows: The hydrochloride was mixed with dichloromethane (750 mL) and water (300 mL) and the pH of the aqueous layer was adjusted to pH 9 with solid sodium bicarbonate. The organic layer was separated, dried over sodium sulfate and carefully evaporated at 80 torr to give the free base., 7709-58-2

7709-58-2 4-(Chloromethyl)thiazole hydrochloride 2763289, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/103045; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

94284-66-9, 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

94284-66-9, General procedure: 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone (1 mol) in methanol (4.0-4.1 l), was added dropwise to a cooled solution of corresponding aromatic aldehydes (1 mol) in 10% NaOH (600-650 ml). The solution was maintained at 0 C for 1.5 h and then was allowed to stir at room temperature. After some time (5-12 h) solid started separating out. The solid was filtered under vacuum and recrystallized from dioxane or ethanol to give the title chalcones. The yield range after recrystallization of chalcones was 32-84%.

The synthetic route of 94284-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liaras; Geronikaki; Glamo?lija; ?iri?; Sokovi?; Bioorganic and Medicinal Chemistry; vol. 19; 10; (2011); p. 3135 – 3140;,
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Thiazole | chemical compound | Britannica

556-90-1,556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.8 5-(4-Chloro-3-nitrobenzylidene)-2-iminothiazolidin-4-one (14h) Orange solid; mp > 200 C; 338 mg, 60% yield; IR (neat) numax = 3214, 3009, 1965, 1693, 1667 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.58 (s, 1H), 9.33 (s, 1H) 8.20 (s, 1H), 7.82-7.89 (m, 2H), 7.62 (s, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 180.28, 175.47, 148.21, 135.23, 134.26, 133.46 132.95, 126.39, 125.98, 125.79; HRMS (ESI-TOF): m/z calculated for C10H6ClN3O3S [M+Na]+, 305.9716; found 305.9712.

The synthetic route of 556-90-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

95-16-9, Benzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

95-16-9, General procedure: To a reaction tube charged with xanthines (0.5 mmol), disulfides (0.3 mmol), Cu(OAc)2¡¤H2O (20 mg, 20 mol %), and AgOAc (1.7 mg, 2 mol %) was added 2 mL of xylene. After stirring at 145 C for 15 h under an O2 atmosphere, the reaction mixture was concentrated and purified by flash column chromatography on silica gel (dichloromethane/acetone = 20:1) to give 143.5 mg (yield: 95%) of compound 3aa as a white solid, mp: 147-149 C; 1H NMR (CDCl3, 600 MHz): delta 7.29-7.37 (m, 5H), 3.93 (s, 3H), 3.57 (s, 3H), 3.40 (s, 3H); 13C NMR (150 MHz, CDCl3): delta 155.0, 151.4, 148.1, 146.4, 130.9, 130.5, 129.6, 128.3, 109.6, 33.2, 29.9, 28.0.

As the paragraph descriping shows that 95-16-9 is playing an increasingly important role.

Reference£º
Article; He, Zuying; Luo, Fang; Li, Yinglong; Zhu, Gangguo; Tetrahedron Letters; vol. 54; 44; (2013); p. 5907 – 5910;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-32-3,Thiazole-5-carboxyaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of imidazole (0.1 mol), (furan-2-ylmethylidene)hydrazine (0.1 mol), and 4-subsituted benzaldehyde (0.1 mol) in 30 cm3 of EtOH was added Cu(Phen)Cl2(10 mol %) at room temperature. The reaction mixture was refluxed for 5 h. The reaction was checked by TLC, and then the solvent was removed under reduced pressure. The final product was purified by flash column chromatography on silica gel using n-hexane/EtOAc., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Alaklab, Abdullah; Surendra Kumar, Radhakrishnan; Ahamed, Anis; Arif, Ibrahim A.; Manilal, Aseer; Idhayadhulla, Akbar; Monatshefte fur Chemie; vol. 148; 2; (2017); p. 275 – 290;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72605-86-8,Methyl 2-chlorothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

2-o-tolyl-chroman-6-ol (2.5 g, 10.4 mmol)2-chloro-thiazole-5-carboxylate(1.9 g, 10.6 mmol, 1.02 equiv.) And potassium carbonate (1.9 g, 1.3 equiv.) In dimethylformamide (30 ml) at 50 C for 10 h.The suspension was cooled to room temperature and diluted with water. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with water, dried over sodium sulfate, filtered, and the solvent was removed under reduced pressure. The crude product was purified by column chromatography (silica gel; ethyl acetate / heptane gradient). The product was obtained as a pale yellow solid (3.87 g, 98%)., 72605-86-8

72605-86-8 Methyl 2-chlorothiazole-5-carboxylate 12897294, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Sanofi; W ¡¤qiehedisiji; J ¡¤weisidun; N ¡¤lakeerman; M ¡¤bodexiwa; P ¡¤aente; K ¡¤wosi; H ¡¤gegelaiyin; O ¡¤licele; V ¡¤kelafute; P ¡¤beierfuge; G ¡¤makete; (91 pag.)CN102993195; (2017); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-23-1,2-Bromo-5-methylthiazole,as a common compound, the synthetic route is as follows.

A mixture of3-brorno-5-chioro-4-fiuorophenol (500 mg, 2.218 mrnol), 2-brorno- 5-methyithiazole (434 mg,2.440 mmol) and Cs2CO3 (1.08 g, 3.33 mmoi) in NMP (6 rnL) was stirred under microwave irradiation at 150C for 30 mm. The mixture was extracted with EtOAc (20 mnLx3), and the organic layer was washed with water (15 mE). The organic layer was dried (Na2SO4) andconcentrated in vacuo. The residue was purified by reverse phase HPLC on a GILSON 281 instrument fitted with a Phenomenex Synergi C18 (250*21.2 mm*4 lim) column using water (0.2% TFA) and ACN as eluenis (Mobile phase A: water (0. 2% TFA). Mobile phase B: ACN, Detector wavelength: 220 nm) followed by concentration in vacuo to obtain the title compound.?H NMR (400 MHz, CDC13) 5 7.43 (dd. J=489, 2.93 Hz, 1 H) 7.34 (dd, J=5.48, 2.74 Hz, I H)6.91 (s, 1 H) 2.38 (s, 3 Fl).

41731-23-1, 41731-23-1 2-Bromo-5-methylthiazole 21906106, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica