Tag: M.W:100-200

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(5-thiazolyl)-3-cyclohexylpropan-1-ol A solution of thiazole-5-carboxaldehyde (2.31 g, 20.4 mmol) in 20 mL of in THF was added to a cold (0 C.) solution of 2-cyclohexylethylmagnesium bromide (prepared from 2-bromoethylcyclohexane (7.88 g) and magnesium turnings (1.22 g)) in 30 mL of ethyl ether and the mixture stirred 30 minutes. The cold bath was removed and the mixture stirred for 2 hours more and then quenched by the addition of 3N aqueous HCl. The solution was stirred until 2 clear phases resulted and then the layers were separated. The pH of the aqueous phase was adjusted to 4 with 2M aqueous sodium carbonate and then extracted with 3 portions of ethyl acetate. All the organic phases were combined and washed with brine, dried, filtered and concentrated. The residue was purified by column chromatography on silica gel (125 g, 50% ethyl acetate/hexanes) to provide 2.69 g (58%) of the title compound. MS (DCI, NH3): 226 (MH+); 243 (M+NH4)+.

1003-32-3, As the paragraph descriping shows that 1003-32-3 is playing an increasingly important role.

Reference£º
Patent; University of Pittsburgh; US6204293; (2001); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1003-61-8, 2-Aminothiazole-5-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Amino-5-formylthiazole (11.5 g, 90 mmol) was dissolved in methanol (120 mL), and sodium borohydride (5.11 g, 135 mmol) was added thereto while cooling with ice, followed by stirring at the same temperature for 1 hour. Acetone (6 mL) and water (10 mL) were added to the reaction mixture, followed by stirring. The residue obtained by evaporating the reaction mixture under reduced pressure was purified using medium pressure silica gel flash column chromatography (methanol:chloroform=1:15), thereby giving the title compound (5.09 g, 43%) as a white solid.

1003-61-8, 1003-61-8 2-Aminothiazole-5-carbaldehyde 2737798, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; TAIHO PHARMACEUTICAL CO., LTD.; Urade, Yoshihiro; Kitade, Makoto; Yamane, Keiko; Aoki, Shinichi; Yamanaka, Hiroyoshi; US2013/165438; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.33 2-(4-(Thiophen-2-yl)butanoyl)benzo[d]isothiazol-3(2H)-one (37) Compound 37 was prepared through 4-(2-thienyl)butyric acid, obtained a white solid in 81% yield. Mp 117.4-118.3 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 7.6 Hz, 1H), 7.33 (dd, J = 4.8, 0.8 Hz, 1H), 6.95 (dd, J = 4.8, 3.6 Hz, 1H), 6.89 (d, J = 2.8 Hz, 1H), 3.16 (t, J = 7.6 Hz, 2H), 2.91 (t, J = 7.6 Hz, 2H), 2.04-1.96 (m, 2H); 13C NMR (101 MHz, DMSO-d6) delta 173.1, 163.5, 144.5, 141.4, 135.0, 127.4, 126.5, 125.7, 125.1, 124.1, 122.5, 36.5, 28.9, 26.2. IR (KBr, cm-1): 1699, 1687. HRMS-ESI (m/z) calcd for C15H13NO3S2 [M+H+] 304.0466, found 304.0478., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-42-5,4-Methylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 18: 4-METHYL-2-HYDRAZINOBENZOTHIAZOLE To a suspension of 4-methyl-2-aminobenzothiazole (5.0 g., 0.03 mole) in 20 ml. of ethylene glycol was added 5.4 g. of 85% hydrazine hydrate (0.09 mole) and 2.75 g. (0.046 mole) acetic acid. The mixture was heated to 126C. under N2 atmosphere for 3 hours. On cooling and dilution with about 1/2 volume of water the product crystallized.

1477-42-5, As the paragraph descriping shows that 1477-42-5 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly and Company; US3937714; (1976); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 24 Intermediate 25 (1.12g, 5.84mmol) and 5-aminothiazole-4-carboxylic acid ethyl ester (0.9g, 5.84mmol) were combined in toluene (25ml_). The mixture was stirred under a nitrogen atmosphere at 60C for 1 hour and then at room temperature for 18 hours. The mixture was partitioned between 1 M hydrochloric acid and ethyl acetate and the layers separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-70% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 24 (298mg) as a cream solid. LCMS (Method 2) Rt 3.09 min; m/z(M+H)+ 328, 18903-18-9

As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

348-40-3, 6-Fluorobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1,1?-Carbonyldiimidazole (12 mmol)was added to a solution of 6-(substituted)benzo[d]thiazol-2-amine (10 mmol) in dry dichloromethane (50 mL) and the reaction was stirred for 20 h at reflux conditions. The reaction mixture was cooled down to 2-8 C, filtered and washed with cold dichloromethane. The crude product was dried under reduced pressure to yield N-(6-(substituted)benzo[d]thiazol-2-yl)-1H-imidazole-1-carboxamide as a white solid (90-95%) and used in next reaction without further purification.

348-40-3, The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hroch, Lukas; Benek, Ondrej; Guest, Patrick; Aitken, Laura; Soukup, Ondrej; Janockova, Jana; Musil, Karel; Dohnal, Vlastimil; Dolezal, Rafael; Kuca, Kamil; Smith, Terry K; Gunn-Moore, Frank; Musilek, Kamil; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3675 – 3678;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

615-21-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

A three-necked reactor equipped with a thermometer was charged with 5.00 g (30.3 mmol) of 2-hy- drazinobenzothiazole and 40 ml of N-methylpyrrolidone under a nitrogen stream to prepare a homogeneous solution. After the addition of 1.82 g (45.4 mmol) of sodium hydroxide and 4.90 g (36.3 mmol) of 4-bromo-1-butene to the solution, the mixture was stirred at 25 C. for 3 hours. After completion of the reaction, the reaction mixture was cooled to 5 C., and 40 ml of water was added to the reaction mixture to precipitate a solid, which was filtered off. The solid was washed with 10 ml of water and 25 ml of heptane, and dried using a vacuum dryer to obtain 6.00 g of a compound 10 as a white solid (conversion rate: 94.0%, reaction selectivity: 96.6%, yield: 84.9%).The structure of the target product was identified by ?H-NMR.10107] ?H-NMR (500 MHz, CDC13, TMS, oe ppm): 7.60 (d, 1H, J=7.8 Hz), 7.54 (d, 1H, J=7.5 Hz), 7.30 (dd, 1H, J=7.8 Hz, 7.8 Hz), 7.07 (dd, 1H, J=7.5 Hz, 7.8 Hz), 5.89 (ddt, 1H, J=10.3 Hz, 17.0 Hz, 7.0 Hz), 5.18 (dd, 1H, J=1.5 Hz, 17.0 Hz), 5.09 (dd, 1H, J=1.5 Hz, 10.3 Hz), 4.27 (s, 2H), 3.86 (t, 2H, J=7.0 Hz), 2.53 (dt, 2H, J=7.0 Hz, 7.0 Hz)

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SANUKI, Kanako; OKUYAMA, Kumi; (12 pag.)US2017/8862; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: The mixture of 6-fluoro-2-hydrazinylbenzo[d]thiazole (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 ¡ãC for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t)., 78364-55-3

The synthetic route of 78364-55-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kukreja, Sharu; Sidhu, Anjali; Sharma, Vineet K.; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 8329 – 8344;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120-75-2,2-Methylbenzothiazole,as a common compound, the synthetic route is as follows.

Synthesis of the intermediate 1-benzyl-2-methylbenzothiazole quaternary ammonium salt. 20 mmol of 2-methylbenzothiazole and 22 mmol of benzyl bromide are added under argon protection into a 50 ml round-bottom flask containing 20 ml toluene, and the reaction mixture is stirred and heated to reflux for 24 hours. After the mixture cools down, the precipitate is filtered and the filter cake is washed with ethyl ether and dried to yield a pale-pink solid powder in a crude yield of 58%., 120-75-2

The synthetic route of 120-75-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.; US2009/17441; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20582-55-2,Ethyl 4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

(1) A mixture was prepared by adding 2.10 g of potassium hydrogen carbonate, 44 mg of palladium chloride (II) and 205 mg of a copper bromide (I) dimethylsulfide complex to 2.20 g of 5-bromo-2-fluoronitrobenzene and the resulting mixture was suspended in 20 mL of toluene. Subsequently, a reaction mixture solution prepared by adding 2.05 g of ethyl 4-methyl-1,3-thiazole-5-carboxylate, 92.5 muL of isobutyric acid and 228 mg of di-t-butylcyclohexylphosphine to the resulting suspension was heated at 120C for 14 hours under a nitrogen atmosphere. The reaction mixture solution was celite-filtered to remove insoluble matter and water was added to the filtrate, and extraction was performed using ethyl acetate. The organic layer was washed with saline and dried and concentrated under reduced pressure. The resulting crude product was separated and purified by silica gel column chromatography to obtain 2.28 g of ethyl 2-(4-fluoro-3-nitrophenyl)-4-methyl-1,3-thiazole-5-carboxylate. ESI/MS m/e: 311.0 (M++H, C13H12FN2O4S)

20582-55-2, 20582-55-2 Ethyl 4-methylthiazole-5-carboxylate 298610, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Teijin Pharma Limited; KAWANA, Asahi; KANAZAWA, Chikashi; TAKAHASHI, Yoshimasa; SHIRAKURA, Takashi; EP2952513; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica